KEGG   Homo sapiens (human): 1544Help
Entry
1544              CDS       H.sapiens                              
Gene name CYP1A2
Definition cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)
Orthology K07409  cytochrome P450, family 1, subfamily A, polypeptide 2
        [EC:1.14.14.1]
Pathway hsa00232  Caffeine metabolism
hsa00380  Tryptophan metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
Class Metabolism; Lipid Metabolism; Linoleic acid metabolism
[PATH:hsa00591]
Metabolism; Amino Acid Metabolism; Tryptophan metabolism
[PATH:hsa00380]
Metabolism; Metabolism of Cofactors and Vitamins; Retinol metabolism
[PATH:hsa00830]
Metabolism; Biosynthesis of Secondary Metabolites; Caffeine
metabolism [PATH:hsa00232]
Metabolism; Xenobiotics Biodegradation and Metabolism; Metabolism of
xenobiotics by cytochrome P450 [PATH:hsa00980]
Metabolism; Xenobiotics Biodegradation and Metabolism; Drug
metabolism - cytochrome P450 [PATH:hsa00982]
Metabolism; Enzyme Families; Cytochrome P450
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: p450
PROSITE: CYTOCHROME_P450
Motif
Other DBs NCBI-GI: 73915100
NCBI-GeneID: 1544
OMIM: 124060
HGNC: 2596
HPRD: 00489
Ensembl: ENSG00000140505
UniProt: P05177
Structure
PDB: 2HI4
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Jmol
Position 15q24.1
AA seq 516 aa AA seqDB search
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
NT seq 1551 nt NT seq  +upstreamnt  +downstreamnt
atggcattgtcccagtctgttcccttctcggccacagagcttctcctggcctctgccatc
ttctgcctggtattctgggtgctcaagggtttgaggcctcgggtccccaaaggcctgaaa
agtccaccagagccatggggctggcccttgctcgggcatgtgctgaccctggggaagaac
ccgcacctggcactgtcaaggatgagccagcgctacggggacgtcctgcagatccgcatt
ggctccacgcccgtgctggtgctgagccgcctggacaccatccggcaggccctggtgcgg
cagggcgacgatttcaagggccggcctgacctctacacctccaccctcatcactgatggc
cagagcttgaccttcagcacagactctggaccggtgtgggctgcccgccggcgcctggcc
cagaatgccctcaacaccttctccatcgcctctgacccagcttcctcatcctcctgctac
ctggaggagcatgtgagcaaggaggctaaggccctgatcagcaggttgcaggagctgatg
gcagggcctgggcacttcgacccttacaatcaggtggtggtgtcagtggccaacgtcatt
ggtgccatgtgcttcggacagcacttccctgagagtagcgatgagatgctcagcctcgtg
aagaacactcatgagttcgtggagactgcctcctccgggaaccccctggacttcttcccc
atccttcgctacctgcctaaccctgccctgcagaggttcaaggccttcaaccagaggttc
ctgtggttcctgcagaaaacagtccaggagcactatcaggactttgacaagaacagtgtc
cgggacatcacgggtgccctgttcaagcacagcaagaaggggcctagagccagcggcaac
ctcatcccacaggagaagattgtcaaccttgtcaatgacatctttggagcaggatttgac
acagtcaccacagccatctcctggagcctcatgtaccttgtgaccaagcctgagatacag
aggaagatccagaaggagctggacactgtgattggcagggagcggcggccccggctctct
gacagaccccagctgccctacttggaggccttcatcctggagaccttccgacactcctcc
ttcttgcccttcaccatcccccacagcacaacaagggacacaacgctgaatggcttctac
atccccaagaaatgctgtgtcttcgtaaaccagtggcaggtcaaccatgacccagagctg
tgggaggacccctctgagttccggcctgagcggttcctcaccgccgatggcactgccatt
aacaagcccttgagtgagaagatgatgctgtttggcatgggcaagcgccggtgtatcggg
gaagtcctggccaagtgggagatcttcctcttcctggccatcctgctacagcaactggag
ttcagcgtgccgccgggcgtgaaagtcgacctgacccccatctacgggctgaccatgaag
cacgcccgctgtgaacatgtccaggcgcggctgcgcttctccatcaactga
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