KEGG H.sapiens: 1555

Homo sapiens (human): 1555

Entry

1555 CDS H.sapiens

Gene name CYP2B6

Definition cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)

Orthology K07412 cytochrome P450, family 2, subfamily B [EC:1.14.14.1]

Pathway hsa00590 Arachidonic acid metabolism
hsa00830 Retinol metabolism
hsa00980 Metabolism of xenobiotics by cytochrome P450
hsa00982 Drug metabolism - cytochrome P450
hsa01100 Metabolic pathways

Class Metabolism; Lipid Metabolism; Arachidonic acid metabolism
[PATH:hsa00590]
Metabolism; Metabolism of Cofactors and Vitamins; Retinol metabolism
[PATH:hsa00830]
Metabolism; Xenobiotics Biodegradation and Metabolism; Metabolism of
xenobiotics by cytochrome P450 [PATH:hsa00980]
Metabolism; Xenobiotics Biodegradation and Metabolism; Drug
metabolism - cytochrome P450 [PATH:hsa00982]
Metabolism; Enzyme Families; Cytochrome P450

SSDB

Motif Pfam: p450
PROSITE: CYTOCHROME_P450

Other DBs NCBI-GI: 7949031
NCBI-GeneID: 1555
OMIM: 123930
HGNC: 2615
HPRD: 00477
Ensembl: ENSG00000197408
UniProt: P20813

Structure

PDB: 3IBD

Position 19q13.2

AA seq 491 aa
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR

NT seq 1476 nt +upstreamnt +downstreamnt
atggaactcagcgtcctcctcttccttgcactcctcacaggactcttgctactcctggtt
cagcgccaccctaacacccatgaccgcctcccaccagggccccgccctctgccccttttg
ggaaaccttctgcagatggatagaagaggcctactcaaatcctttctgaggttccgagag
aaatatggggacgtcttcacggtacacctgggaccgaggcccgtggtcatgctgtgtgga
gtagaggccatacgggaggcccttgtggacaaggctgaggccttctctggccggggaaaa
atcgccatggtcgacccattcttccggggatatggtgtgatctttgccaatggaaaccgc
tggaaggtgcttcggcgattctctgtgaccactatgagggacttcgggatgggaaagcgg
agtgtggaggagcggattcaggaggaggctcagtgtctgatagaggagcttcggaaatcc
aagggggccctcatggaccccaccttcctcttccagtccattaccgccaacatcatctgc
tccatcgtctttggaaaacgattccactaccaagatcaagagttcctgaagatgctgaac
ttgttctaccagactttttcactcatcagctctgtattcggccagctgtttgagctcttc
tctggcttcttgaaatactttcctggggcacacaggcaagtttacaaaaacctgcaggaa
atcaatgcttacattggccacagtgtggagaagcaccgtgaaaccctggaccccagcgcc
cccaaggacctcatcgacacctacctgctccacatggaaaaagagaaatccaacgcacac
agtgaattcagccaccagaacctcaacctcaacacgctctcgctcttctttgctggcact
gagaccaccagcaccactctccgctacggcttcctgctcatgctcaaataccctcatgtt
gcagagagagtctacagggagattgaacaggtgattggcccacatcgccctccagagctt
catgaccgagccaaaatgccatacacagaggcagtcatctatgagattcagagattttcc
gaccttctccccatgggtgtgccccacattgtcacccaacacaccagcttccgagggtac
atcatccccaaggacacagaagtatttctcatcctgagcactgctctccatgacccacac
tactttgaaaaaccagacgccttcaatcctgaccactttctggatgccaatggggcactg
aaaaagactgaagcttttatccccttctccttagggaagcggatttgtcttggtgaaggc
atcgcccgtgcggaattgttcctcttcttcaccaccatcctccagaacttctccatggcc
agccccgtggccccagaagacatcgatctgacaccccaggagtgtggtgtgggcaaaata
cccccaacataccagatccgcttcctgccccgctga

All links

Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (7)   
   KEGG DRUG (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (3)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (45)

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