KEGG H.sapiens: 1565

Homo sapiens (human): 1565

Entry

1565 CDS H.sapiens

Gene name CYP2D6

Definition cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)

Orthology K07414 cytochrome P450, family 2, subfamily D [EC:1.14.14.1]

Pathway hsa00982 Drug metabolism - cytochrome P450

Class Metabolism; Xenobiotics Biodegradation and Metabolism; Drug
metabolism - cytochrome P450 [PATH:hsa00982]
Metabolism; Enzyme Families; Cytochrome P450

SSDB

Motif Pfam: p450
PROSITE: CYTOCHROME_P450

Other DBs NCBI-GI: 40805836
NCBI-GeneID: 1565
OMIM: 124030
HGNC: 2625
HPRD: 00487
Ensembl: ENSG00000100197
UniProt: Q5Y7H2 Q6NWU0

Structure

PDB: 2F9Q

Position 22q13.1

AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVTPSPYELCAVPR

NT seq 1494 nt +upstreamnt +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctacccaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggtttcgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtctccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgtgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctcggtgcccactggacagccccggcccagccaccatggtgtc
tttgctttcctggtgaccccatccccctatgagctttgtgctgtgccccgctag

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (125)   
   KEGG DRUG (125)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (25)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (13)   
   UniProt (2)   
   RefSeq(pep) (2)   
   IPI (9)   
DNA sequence (48)   
   RefSeq(nuc) (2)   
   GenBank (23)   
   EMBL (23)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (224)

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