KEGG H.sapiens: 1723

Homo sapiens (human): 1723

Entry

1723 CDS H.sapiens

Gene name DHODH

Definition dihydroorotate dehydrogenase (EC:1.3.5.2)

Orthology K00254 dihydroorotate dehydrogenase [EC:1.3.5.2]

Pathway hsa00240 Pyrimidine metabolism
hsa01100 Metabolic pathways

Class Metabolism; Nucleotide Metabolism; Pyrimidine metabolism
[PATH:hsa00240]

SSDB

Motif Pfam: DHO_dh FMN_dh PASTA Trp_syntA PcrB
PROSITE: DHODEHASE_1 DHODEHASE_2

Other DBs NCBI-GI: 45006951
NCBI-GeneID: 1723
OMIM: 126064
HGNC: 2867
HPRD: 00521
Ensembl: ENSG00000102967
UniProt: Q02127

Structure

PDB: 1D3G 3G0X 3FJ6 2FPV 1D3H 3FJL 2FQI 3G0U
     3F1Q 2FPY 2B0M 2PRL 2BXV 2PRH 2FPT 2PRM

Position 16q22

AA seq 395 aa
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR

NT seq 1188 nt +upstreamnt +downstreamnt
atggcgtggagacacctgaaaaagcgggcccaggatgctgtgatcatcctggggggagga
ggacttctcttcgcctcctacctgatggccacgggagatgagcgtttctatgctgaacac
ctgatgccgactctgcaggggctgctggacccggagtcagcccacagactggctgttcgc
ttcacctccctggggctccttccacgggccagatttcaagactctgacatgctggaagtg
agagttctgggccataaattccgaaatccagtaggaattgctgcaggatttgacaagcat
ggggaagccgtggacggactttataagatgggctttggttttgttgagataggaagtgtg
actccaaaacctcaggaaggaaaccctagacccagagtcttccgcctccctgaggaccaa
gctgtcattaacaggtatggatttaacagtcacgggctttcagtggtggaacacaggtta
cgggccagacagcagaagcaggccaagctcacagaagatggactgcctctgggggtcaac
ttggggaagaacaagacctcagtggacgccgcggaggactacgcagaaggggtgcgcgta
ctgggccccctggccgactacctggtggtgaatgtgtccagccccaacactgccgggctg
cggagccttcagggaaaggccgagctgcgccgcctgctgaccaaggtgctgcaggagagg
gatggcttgcggagagtgcacaggccggcagtcctggtgaagatcgctcctgacctcacc
agccaggataaggaggacattgccagtgtggtcaaagagttgggcatcgatgggctgatt
gttacgaacaccaccgtgagtcgccctgcgggcctccagggtgccctgcgctctgaaaca
ggagggctgagtgggaagcccctccgggatttatcaactcaaaccattcgggagatgtat
gcactcacccaaggccgagttcccataattggggttggtggtgtgagcagcgggcaggac
gcgctggagaagatccgggcaggggcctccctggtgcagctgtacacggccctcaccttc
tgggggccacccgttgtgggcaaagtcaagcgggaactggaggcccttctgaaagagcag
ggctttggcggagtcacagatgccattggagcagatcatcggaggtga

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (3)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
3D Structure (16)   
   PDB (16)   
Protein domain (7)   
   Pfam (5)   
   PROSITE (2)   
All databases (54)

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