KEGG H.sapiens: 1788

Homo sapiens (human): 1788

Entry

1788 CDS H.sapiens

Gene name DNMT3A

Definition DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37)

Orthology K00558 DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37]

Pathway hsa00270 Cysteine and methionine metabolism
hsa01100 Metabolic pathways

Class Metabolism; Amino Acid Metabolism; Cysteine and methionine
metabolism [PATH:hsa00270]
Genetic Information Processing; Replication and Repair; DNA
replication proteins

SSDB

Motif Pfam: PWWP DNA_methylase
PROSITE: C5_MTASE_1 CYS_RICH PWWP

Other DBs NCBI-GI: 12751473
NCBI-GeneID: 1788
OMIM: 602769
HGNC: 2978
HPRD: 04141
Ensembl: ENSG00000119772
UniProt: Q9Y6K1

Structure

PDB: 3A1B 3A1A 2QRV

Position 2p23

AA seq 912 aa
MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
LFAPLKEYFACV

NT seq 2739 nt +upstreamnt +downstreamnt
atgcccgccatgccctccagcggccccggggacaccagcagctctgctgcggagcgggag
gaggaccgaaaggacggagaggagcaggaggagccgcgtggcaaggaggagcgccaagag
cccagcaccacggcacggaaggtggggcggcctgggaggaagcgcaagcaccccccggtg
gaaagcggtgacacgccaaaggaccctgcggtgatctccaagtccccatccatggcccag
gactcaggcgcctcagagctattacccaatggggacttggagaagcggagtgagccccag
ccagaggaggggagccctgctggggggcagaagggcggggccccagcagagggagagggt
gcagctgagaccctgcctgaagcctcaagagcagtggaaaatggctgctgcacccccaag
gagggccgaggagcccctgcagaagcgggcaaagaacagaaggagaccaacatcgaatcc
atgaaaatggagggctcccggggccggctgcggggtggcttgggctgggagtccagcctc
cgtcagcggcccatgccgaggctcaccttccaggcgggggacccctactacatcagcaag
cgcaagcgggacgagtggctggcacgctggaaaagggaggctgagaagaaagccaaggtc
attgcaggaatgaatgctgtggaagaaaaccaggggcccggggagtctcagaaggtggag
gaggccagccctcctgctgtgcagcagcccactgaccccgcatcccccactgtggctacc
acgcctgagcccgtggggtccgatgctggggacaagaatgccaccaaagcaggcgatgac
gagccagagtacgaggacggccggggctttggcattggggagctggtgtgggggaaactg
cggggcttctcctggtggccaggccgcattgtgtcttggtggatgacgggccggagccga
gcagctgaaggcacccgctgggtcatgtggttcggagacggcaaattctcagtggtgtgt
gttgagaagctgatgccgctgagctcgttttgcagtgcgttccaccaggccacgtacaac
aagcagcccatgtaccgcaaagccatctacgaggtcctgcaggtggccagcagccgcgcg
gggaagctgttcccggtgtgccacgacagcgatgagagtgacactgccaaggccgtggag
gtgcagaacaagcccatgattgaatgggccctggggggcttccagccttctggccctaag
ggcctggagccaccagaagaagagaagaatccctacaaagaagtgtacacggacatgtgg
gtggaacctgaggcagctgcctacgcaccacctccaccagccaaaaagccccggaagagc
acagcggagaagcccaaggtcaaggagattattgatgagcgcacaagagagcggctggtg
tacgaggtgcggcagaagtgccggaacattgaggacatctgcatctcctgtgggagcctc
aatgttaccctggaacaccccctcttcgttggaggaatgtgccaaaactgcaagaactgc
tttctggagtgtgcgtaccagtacgacgacgacggctaccagtcctactgcaccatctgc
tgtgggggccgtgaggtgctcatgtgcggaaacaacaactgctgcaggtgcttttgcgtg
gagtgtgtggacctcttggtggggccgggggctgcccaggcagccattaaggaagacccc
tggaactgctacatgtgcgggcacaagggtacctacgggctgctgcggcggcgagaggac
tggccctcccggctccagatgttcttcgctaataaccacgaccaggaatttgaccctcca
aaggtttacccacctgtcccagctgagaagaggaagcccatccgggtgctgtctctcttt
gatggaatcgctacagggctcctggtgctgaaggacttgggcattcaggtggaccgctac
attgcctcggaggtgtgtgaggactccatcacggtgggcatggtgcggcaccaggggaag
atcatgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtggggccca
ttcgatctggtgattgggggcagtccctgcaatgacctctccatcgtcaaccctgctcgc
aagggcctctacgagggcactggccggctcttctttgagttctaccgcctcctgcatgat
gcgcggcccaaggagggagatgatcgccccttcttctggctctttgagaatgtggtggcc
atgggcgttagtgacaagagggacatctcgcgatttctcgagtccaaccctgtgatgatt
gatgccaaagaagtgtcagctgcacacagggcccgctacttctggggtaaccttcccggt
atgaacaggccgttggcatccactgtgaatgataagctggagctgcaggagtgtctggag
catggcaggatagccaagttcagcaaagtgaggaccattactacgaggtcaaactccata
aagcagggcaaagaccagcattttcctgtcttcatgaatgagaaagaggacatcttatgg
tgcactgaaatggaaagggtatttggtttcccagtccactatactgacgtctccaacatg
agccgcttggcgaggcagagactgctgggccggtcatggagcgtgccagtcatccgccac
ctcttcgctccgctgaaggagtattttgcgtgtgtgtaa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (10)   
   UniProt (1)   
   RefSeq(pep) (4)   
   IPI (5)   
DNA sequence (12)   
   RefSeq(nuc) (4)   
   GenBank (4)   
   EMBL (4)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (2)   
   PROSITE (3)   
All databases (45)

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