KEGG H.sapiens: 1806

Homo sapiens (human): 1806

Entry

1806 CDS H.sapiens

Gene name DPYD

Definition dihydropyrimidine dehydrogenase (EC:1.3.1.2)

Orthology K00207 dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]

Pathway hsa00240 Pyrimidine metabolism
hsa00410 beta-Alanine metabolism
hsa00770 Pantothenate and CoA biosynthesis
hsa00983 Drug metabolism - other enzymes
hsa01100 Metabolic pathways

Disease H00193 Dihydropyrimidine dehydrogenase deficiency

Class Metabolism; Nucleotide Metabolism; Pyrimidine metabolism
[PATH:hsa00240]
Metabolism; Metabolism of Other Amino Acids; beta-Alanine metabolism
[PATH:hsa00410]
Metabolism; Metabolism of Cofactors and Vitamins; Pantothenate and
CoA biosynthesis [PATH:hsa00770]
Metabolism; Xenobiotics Biodegradation and Metabolism; Drug
metabolism - other enzymes [PATH:hsa00983]

SSDB

Motif Pfam: DHO_dh Pyr_redox_2 Dus Pyr_redox Fer4 Shikimate_DH PcrB
PROSITE: 4FE4S_FERREDOXIN

Other DBs NCBI-GI: 119943098
NCBI-GeneID: 1806
OMIM: 612779
HGNC: 3012
HPRD: 02036
Ensembl: ENSG00000188641
UniProt: Q12882

Position 1p22

AA seq 1025 aa
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC

NT seq 3078 nt +upstreamnt +downstreamnt
atggcccctgtgctcagtaaggactcggcggacatcgagagtatcctggctttaaatcct
cgaacacaaactcatgcaactctgtgttccacttcggccaagaaattagacaagaaacat
tggaaaagaaatcctgataagaactgctttaattgtgagaagctggagaataattttgat
gacatcaagcacacgactcttggtgagcgaggagctctccgagaagcaatgagatgcctg
aaatgtgcagatgccccgtgtcagaagagctgtccaactaatcttgatattaaatcattc
atcacaagtattgcaaacaagaactattatggagctgctaagatgatattttctgacaac
ccacttggtctgacttgtggaatggtatgtccaacctctgatctttgtgtaggtggatgc
aatttatatgccactgaagagggacccattaatattggtggattgcagcaatttgctact
gaggtattcaaagcaatgagtatcccacagatcagaaatccttcgctgcctcccccagaa
aaaatgtctgaagcctattctgcaaagattgctctttttggtgctgggcctgcaagtata
agttgtgcttcctttttggctcgattggggtactctgacatcactatatttgaaaaacaa
gaatatgttggtggtttaagtacttctgaaattcctcagttccggctgccgtatgatgta
gtgaattttgagattgagctaatgaaggaccttggtgtaaagataatttgcggtaaaagc
ctttcagtgaatgaaatgactcttagcactttgaaagaaaaaggctacaaagctgctttc
attggaataggtttgccagaacccaataaagatgccatcttccaaggcctgacgcaggac
caggggttttatacatccaaagactttttgccacttgtagccaaaggcagtaaagcagga
atgtgcgcctgtcactctccattgccatcgatacggggagtcgtgattgtacttggagct
ggagacactgcctttgactgtgcaacatctgctctacgttgtggagctcgccgtgtgttc
atcgtcttcagaaaaggctttgttaatataagagctgtccctgaggagatggaacttgct
aaggaagaaaagtgtgaatttctgccattcctgtccccacggaaggttatagtaaaaggt
gggagaattgttgctatgcagtttgttcggacagagcaagatgaaactggaaaatggaat
gaagatgaagatcagatggtccatctgaaagccgatgtggtcatcagtgcctttggttca
gttctgagtgatcctaaagtaaaagaagccttgagccctataaaatttaacagatggggt
ctcccagaagtagatccagaaactatgcaaactagtgaagcatgggtatttgcaggtggt
gatgtcgttggtttggctaacactacagtggaatcggtgaatgatggaaagcaagcttct
tggtacattcacaaatacgtacagtcacaatatggagcttccgtttctgccaagcctgaa
ctacccctcttttacactcctattgatctggtggacattagtgtagaaatggccggattg
aagtttataaatccttttggtcttgctagcgcaactccagccaccagcacatcaatgatt
cgaagagcttttgaagctggatggggttttgccctcaccaaaactttctctcttgataag
gacattgtgacaaatgtttcccccagaatcatccggggaaccacctctggccccatgtat
ggccctggacaaagctcctttctgaatattgagctcatcagtgagaaaacggctgcatat
tggtgtcaaagtgtcactgaactaaaggctgactttccagacaacattgtgattgctagc
attatgtgcagttacaataaaaatgactggacggaacttgccaagaagtctgaggattct
ggagcagatgccctggagttaaatttatcatgtccacatggcatgggagaaagaggaatg
ggcctggcctgtgggcaggatccagagctggtgcggaacatctgccgctgggttaggcaa
gctgttcagattcctttttttgccaagctgaccccaaatgtcactgatattgtgagcatc
gcaagagctgcaaaggaaggtggtgccaatggcgttacagccaccaacactgtctcaggt
ctgatgggattaaaatctgatggcacaccttggccagcagtggggattgcaaagcgaact
acatatggaggagtgtctgggacagcaatcagacctattgctttgagagctgtgacctcc
attgctcgtgctctgcctggatttcccattttggctactggtggaattgactctgctgaa
agtggtcttcagtttctccatagtggtgcttccgtcctccaggtatgcagtgccattcag
aatcaggatttcactgtgatcgaagactactgcactggcctcaaagccctgctttatctg
aaaagcattgaagaactacaagactgggatggacagagtccagctactgtgagtcaccag
aaagggaaaccagttccacgtatagctgaactcatggacaagaaactgccaagttttgga
ccttatctggaacagcgcaagaaaatcatagcagaaaacaagattagactgaaagaacaa
aatgtagctttttcaccacttaagagaaactgttttatccccaaaaggcctattcctacc
atcaaggatgtaataggaaaagcactgcagtaccttggaacatttggtgaattgagcaac
gtagagcaagttgtggctatgattgatgaagaaatgtgtatcaactgtggtaaatgctac
atgacctgtaatgattctggctaccaggctatacagtttgatccagaaacccacctgccc
accataaccgacacttgtacaggctgtactctgtgtctcagtgtttgccctattgtcgac
tgcatcaaaatggtttccaggacaacaccttatgaaccaaagagaggcgtacccttatct
gtgaatccggtgtgttaa

All links

Pathway (5)   
   KEGG PATHWAY (5)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (4)   
   KEGG DRUG (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (7)   
   UniProt (1)   
   RefSeq(pep) (2)   
   IPI (4)   
DNA sequence (24)   
   RefSeq(nuc) (2)   
   GenBank (11)   
   EMBL (11)   
Protein domain (8)   
   Pfam (7)   
   PROSITE (1)   
All databases (65)

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