KEGG H.sapiens: 191

Homo sapiens (human): 191

Entry

191 CDS H.sapiens

Gene name AHCY

Definition adenosylhomocysteinase (EC:3.3.1.1)

Orthology K01251 adenosylhomocysteinase [EC:3.3.1.1]

Pathway hsa00270 Cysteine and methionine metabolism
hsa00450 Selenoamino acid metabolism
hsa01100 Metabolic pathways

Disease H00184 Hypermethioninemia

Class Metabolism; Amino Acid Metabolism; Cysteine and methionine
metabolism [PATH:hsa00270]
Metabolism; Metabolism of Other Amino Acids; Selenoamino acid
metabolism [PATH:hsa00450]

SSDB

Motif Pfam: AdoHcyase AdoHcyase_NAD 2-Hacid_dh_C IlvN TrkA_N 3HCDH_N
ELFV_dehydrog CDC37_C
PROSITE: ADOHCYASE_1 ADOHCYASE_2

Other DBs NCBI-GI: 9951915
NCBI-GeneID: 191
OMIM: 180960
HGNC: 343
HPRD: 01621
Ensembl: ENSG00000101444
UniProt: B3KUN3 P23526

Structure

PDB: 1LI4 1A7A

Position 20cen-q13.1

AA seq 432 aa
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY

NT seq 1299 nt +upstreamnt +downstreamnt
atgtctgacaaactgccctacaaagtcgccgacatcggcctggctgcctggggacgcaag
gccctggacattgctgagaacgagatgccgggcctgatgcgtatgcgggagcggtactcg
gcctccaagccactgaagggcgcccgcatcgctggctgcctgcacatgaccgtggagacg
gccgtcctcattgagaccctcgtcaccctgggtgctgaggtgcagtggtccagctgcaac
atcttctccacccaggaccatgcggcggctgccattgccaaggctggcattccggtgtat
gcctggaagggcgaaacggacgaggagtacctgtggtgcattgagcagaccctgtacttc
aaggacgggcccctcaacatgattctggacgacgggggcgacctcaccaacctcatccac
accaagtacccgcagcttctgccaggcatccgaggcatctctgaggagaccacgactggg
gtccacaacctctacaagatgatggccaatgggatcctcaaggtgcctgccatcaatgtc
aatgactccgtcaccaagagcaagtttgacaacctctatggctgccgggagtccctcata
gatggcatcaagcgggccacagatgtgatgattgccggcaaggtagcggtggtagcaggc
tatggtgatgtgggcaagggctgtgcccaggccctgcggggtttcggagcccgcgtcatc
atcaccgagattgaccccatcaacgcactgcaggctgccatggagggctatgaggtgacc
accatggatgaggcctgtcaggagggcaacatctttgtcaccaccacaggctgtattgac
atcatccttggccggcactttgagcagatgaaggatgatgccattgtgtgtaacattgga
cactttgacgtggagatcgatgtcaagtggctcaacgagaacgccgtggagaaggtgaac
atcaagccgcaggtggaccggtatcggttgaagaatgggcgccgcatcatcctgctggcc
gagggtcggctggtcaacctgggttgtgccatgggccaccccagcttcgtgatgagtaac
tccttcaccaaccaggtgatggcgcagatcgagctgtggacccatccagacaagtacccc
gttggggttcatttcctgcccaagaagctggatgaggcagtggctgaagcccacctgggc
aagctgaatgtgaagttgaccaagctaactgagaagcaagcccagtacctgggcatgtcc
tgtgatggccccttcaagccggatcactaccgctactga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (6)   
   UniProt (2)   
   RefSeq(pep) (2)   
   IPI (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
3D Structure (2)   
   PDB (2)   
Protein domain (10)   
   Pfam (8)   
   PROSITE (2)   
All databases (42)

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