KEGG   Homo sapiens (human): 2064Help
Entry
2064              CDS       T01001                                 

Gene name
ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1
Definition
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)
Orthology
K05083  
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
ErbB signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Focal adhesion
Adherens junction
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Bladder cancer
Non-small cell lung cancer
Disease
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00022  
Bladder cancer
H00026  
Endometrial Cancer
H00027  
Ovarian cancer
H00028  
Choriocarcinoma
H00030  
Cervical cancer
H00031  
Breast cancer
H00046  
Cholangiocarcinoma
Drug target
Trastuzumab: 
Pertuzumab: 
Trastuzumab emtansine: 
Lapatinib: 
Afatinib: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    2064 (ERBB2)
   04066 HIF-1 signaling pathway
    2064 (ERBB2)
   04020 Calcium signaling pathway
    2064 (ERBB2)
 Cellular Processes
  Cellular commiunity
   04510 Focal adhesion
    2064 (ERBB2)
   04520 Adherens junction
    2064 (ERBB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    2064 (ERBB2)
   05206 MicroRNAs in cancer
    2064 (ERBB2)
   05205 Proteoglycans in cancer
    2064 (ERBB2)
   05212 Pancreatic cancer
    2064 (ERBB2)
   05219 Bladder cancer
    2064 (ERBB2)
   05215 Prostate cancer
    2064 (ERBB2)
   05213 Endometrial cancer
    2064 (ERBB2)
   05223 Non-small cell lung cancer
    2064 (ERBB2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2064 (ERBB2)
Protein kinases [BR:hsa01001]
 Tyrosine protein kinases
  EGFR family [OT]
   2064 (ERBB2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   2064 (ERBB2)
Enzyme-linked receptors [BR:hsa01020]
 Receptor tyrosine kinases
  RTK class I (EGF receptor family)
   2064 (ERBB2)
Cytokine receptors [BR:hsa04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   2064 (ERBB2)
Cellular antigens [BR:hsa04090]
 Proteins
  2064 (ERBB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
17q12
AA seq 1225 aa AA seqDB search
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQ
VRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK
GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA
LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR
CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA
CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC
THSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRL
LQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV
RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL
DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ
NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS
STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQ
RYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERP
KTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPER
GAPPSTFKGTPTAENPEYLGLDVPV
NT seq 3678 nt NT seq  +upstreamnt  +downstreamnt
atgaagctgcggctccctgccagtcccgagacccacctggacatgctccgccacctctac
cagggctgccaggtggtgcagggaaacctggaactcacctacctgcccaccaatgccagc
ctgtccttcctgcaggatatccaggaggtgcagggctacgtgctcatcgctcacaaccaa
gtgaggcaggtcccactgcagaggctgcggattgtgcgaggcacccagctctttgaggac
aactatgccctggccgtgctagacaatggagacccgctgaacaataccacccctgtcaca
ggggcctccccaggaggcctgcgggagctgcagcttcgaagcctcacagagatcttgaaa
ggaggggtcttgatccagcggaacccccagctctgctaccaggacacgattttgtggaag
gacatcttccacaagaacaaccagctggctctcacactgatagacaccaaccgctctcgg
gcctgccacccctgttctccgatgtgtaagggctcccgctgctggggagagagttctgag
gattgtcagagcctgacgcgcactgtctgtgccggtggctgtgcccgctgcaaggggcca
ctgcccactgactgctgccatgagcagtgtgctgccggctgcacgggccccaagcactct
gactgcctggcctgcctccacttcaaccacagtggcatctgtgagctgcactgcccagcc
ctggtcacctacaacacagacacgtttgagtccatgcccaatcccgagggccggtataca
ttcggcgccagctgtgtgactgcctgtccctacaactacctttctacggacgtgggatcc
tgcaccctcgtctgccccctgcacaaccaagaggtgacagcagaggatggaacacagcgg
tgtgagaagtgcagcaagccctgtgcccgagtgtgctatggtctgggcatggagcacttg
cgagaggtgagggcagttaccagtgccaatatccaggagtttgctggctgcaagaagatc
tttgggagcctggcatttctgccggagagctttgatggggacccagcctccaacactgcc
ccgctccagccagagcagctccaagtgtttgagactctggaagagatcacaggttaccta
tacatctcagcatggccggacagcctgcctgacctcagcgtcttccagaacctgcaagta
atccggggacgaattctgcacaatggcgcctactcgctgaccctgcaagggctgggcatc
agctggctggggctgcgctcactgagggaactgggcagtggactggccctcatccaccat
aacacccacctctgcttcgtgcacacggtgccctgggaccagctctttcggaacccgcac
caagctctgctccacactgccaaccggccagaggacgagtgtgtgggcgagggcctggcc
tgccaccagctgtgcgcccgagggcactgctggggtccagggcccacccagtgtgtcaac
tgcagccagttccttcggggccaggagtgcgtggaggaatgccgagtactgcaggggctc
cccagggagtatgtgaatgccaggcactgtttgccgtgccaccctgagtgtcagccccag
aatggctcagtgacctgttttggaccggaggctgaccagtgtgtggcctgtgcccactat
aaggaccctcccttctgcgtggcccgctgccccagcggtgtgaaacctgacctctcctac
atgcccatctggaagtttccagatgaggagggcgcatgccagccttgccccatcaactgc
acccactcctgtgtggacctggatgacaagggctgccccgccgagcagagagccagccct
ctgacgtccatcatctctgcggtggttggcattctgctggtcgtggtcttgggggtggtc
tttgggatcctcatcaagcgacggcagcagaagatccggaagtacacgatgcggagactg
ctgcaggaaacggagctggtggagccgctgacacctagcggagcgatgcccaaccaggcg
cagatgcggatcctgaaagagacggagctgaggaaggtgaaggtgcttggatctggcgct
tttggcacagtctacaagggcatctggatccctgatggggagaatgtgaaaattccagtg
gccatcaaagtgttgagggaaaacacatcccccaaagccaacaaagaaatcttagacgaa
gcatacgtgatggctggtgtgggctccccatatgtctcccgccttctgggcatctgcctg
acatccacggtgcagctggtgacacagcttatgccctatggctgcctcttagaccatgtc
cgggaaaaccgcggacgcctgggctcccaggacctgctgaactggtgtatgcagattgcc
aaggggatgagctacctggaggatgtgcggctcgtacacagggacttggccgctcggaac
gtgctggtcaagagtcccaaccatgtcaaaattacagacttcgggctggctcggctgctg
gacattgacgagacagagtaccatgcagatgggggcaaggtgcccatcaagtggatggcg
ctggagtccattctccgccggcggttcacccaccagagtgatgtgtggagttatggtgtg
actgtgtgggagctgatgacttttggggccaaaccttacgatgggatcccagcccgggag
atccctgacctgctggaaaagggggagcggctgccccagccccccatctgcaccattgat
gtctacatgatcatggtcaaatgttggatgattgactctgaatgtcggccaagattccgg
gagttggtgtctgaattctcccgcatggccagggacccccagcgctttgtggtcatccag
aatgaggacttgggcccagccagtcccttggacagcaccttctaccgctcactgctggag
gacgatgacatgggggacctggtggatgctgaggagtatctggtaccccagcagggcttc
ttctgtccagaccctgccccgggcgctgggggcatggtccaccacaggcaccgcagctca
tctaccaggagtggcggtggggacctgacactagggctggagccctctgaagaggaggcc
cccaggtctccactggcaccctccgaaggggctggctccgatgtatttgatggtgacctg
ggaatgggggcagccaaggggctgcaaagcctccccacacatgaccccagccctctacag
cggtacagtgaggaccccacagtacccctgccctctgagactgatggctacgttgccccc
ctgacctgcagcccccagcctgaatatgtgaaccagccagatgttcggccccagccccct
tcgccccgagagggccctctgcctgctgcccgacctgctggtgccactctggaaaggccc
aagactctctccccagggaagaatggggtcgtcaaagacgtttttgcctttgggggtgcc
gtggagaaccccgagtacttgacaccccagggaggagctgcccctcagccccaccctcct
cctgccttcagcccagccttcgacaacctctattactgggaccaggacccaccagagcgg
ggggctccacccagcaccttcaaagggacacctacggcagagaacccagagtacctgggt
ctggacgtgccagtgtga

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