KEGG H.sapiens: 211

Homo sapiens (human): 211

Entry

211 CDS H.sapiens

Gene name ALAS1

Definition aminolevulinate, delta-, synthase 1 (EC:2.3.1.37)

Orthology K00643 5-aminolevulinate synthase [EC:2.3.1.37]

Pathway hsa00260 Glycine, serine and threonine metabolism
hsa00860 Porphyrin and chlorophyll metabolism
hsa01100 Metabolic pathways

Class Metabolism; Amino Acid Metabolism; Glycine, serine and threonine
metabolism [PATH:hsa00260]
Metabolism; Metabolism of Cofactors and Vitamins; Porphyrin and
chlorophyll metabolism [PATH:hsa00860]

SSDB

Motif Pfam: Aminotran_1_2 Preseq_ALAS Cys_Met_Meta_PP Aminotran_5
Beta_elim_lyase DegT_DnrJ_EryC1
PROSITE: AA_TRANSFER_CLASS_2

Other DBs NCBI-GI: 4502025
NCBI-GeneID: 211
OMIM: 125290
HGNC: 396
HPRD: 00505
Ensembl: ENSG00000023330
UniProt: P13196 Q5JAM2

Position 3p21.1

AA seq 640 aa
MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKE
TPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGS
SVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE
RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLI
TKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADL
HGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHND
VSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYG
ARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPM
LLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKN
TEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLE
LKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA

NT seq 1923 nt +upstreamnt +downstreamnt
atggagagtgttgttcgccgctgcccattcttatcccgagtcccccaggcctttctgcag
aaagcaggcaaatctctgttgttctatgcccaaaactgccccaagatgatggaagttggg
gccaagccagcccctcgggcattgtccactgcagcagtacactaccaacagatcaaagaa
acccctccggccagtgagaaagacaaaactgctaaggccaaggtccaacagactcctgat
ggatcccagcagagtccagatggcacacagcttccgtctggacaccccttgcctgccaca
agccagggcactgcaagcaaatgccctttcctggcagcacagatgaatcagagaggcagc
agtgtcttctgcaaagccagtcttgagcttcaggaggatgtgcaggaaatgaatgccgtg
aggaaagaggttgctgaaacctcagcaggccccagtgtggttagtgtgaaaaccgatgga
ggggatcccagtggactgctgaagaacttccaggacatcatgcaaaagcaaagaccagaa
agagtgtctcatcttcttcaagataacttgccaaaatctgtttccacttttcagtatgat
cgtttctttgagaaaaaaattgatgagaaaaagaatgaccacacctatcgagtttttaaa
actgtgaaccggcgagcacacatcttccccatggcagatgactattcagactccctcatc
accaaaaagcaagtgtcagtctggtgcagtaatgactacctaggaatgagtcgccaccca
cgggtgtgtggggcagttatggacactttgaaacaacatggtgctggggcaggtggtact
agaaatatttctggaactagtaaattccatgtggacttagagcgggagctggcagacctc
catgggaaagatgccgcactcttgttttcctcgtgctttgtggccaatgactcaaccctc
ttcaccctggctaagatgatgccaggctgtgagatttactctgattctgggaaccatgcc
tccatgatccaagggattcgaaacagccgagtgccaaagtacatcttccgccacaatgat
gtcagccacctcagagaactgctgcaaagatctgacccctcagtccccaagattgtggca
tttgaaactgtccattcaatggatggggcggtgtgcccactggaagagctgtgtgatgtg
gcccatgagtttggagcaatcaccttcgtggatgaggtccacgcagtggggctttatggg
gctcgaggcggagggattggggatcgggatggagtcatgccaaaaatggacatcatttct
ggaacacttggcaaagcctttggttgtgttggagggtacatcgccagcacgagttctctg
attgacaccgtacggtcctatgctgctggcttcatcttcaccacctctctgccacccatg
ctgctggctggagccctggagtctgtgcggatcctgaagagcgctgagggacgggtgctt
cgccgccagcaccagcgcaacgtcaaactcatgagacagatgctaatggatgccggcctc
cctgttgtccactgccccagccacatcatccctgtgcgggttgcagatgctgctaaaaac
acagaagtctgtgatgaactaatgagcagacataacatctacgtgcaagcaatcaattac
cctacggtgccccggggagaagagctcctacggattgcccccacccctcaccacacaccc
cagatgatgaactacttccttgagaatctgctagtcacatggaagcaagtggggctggaa
ctgaagcctcattcctcagctgagtgcaacttctgcaggaggccactgcattttgaagtg
atgagtgaaagagagaagtcctatttctcaggcttgagcaagttggtatctgctcaggcc
tga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (12)   
   UniProt (2)   
   RefSeq(pep) (2)   
   IPI (8)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (7)   
   Pfam (6)   
   PROSITE (1)   
All databases (41)

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