KEGG H.sapiens: 231

Homo sapiens (human): 231

Entry

231 CDS H.sapiens

Gene name AKR1B1

Definition aldo-keto reductase family 1, member B1 (aldose reductase)
(EC:1.1.1.21)

Orthology K00011 aldehyde reductase [EC:1.1.1.21]

Pathway hsa00040 Pentose and glucuronate interconversions
hsa00051 Fructose and mannose metabolism
hsa00052 Galactose metabolism
hsa00561 Glycerolipid metabolism
hsa00620 Pyruvate metabolism
hsa01100 Metabolic pathways

Class Metabolism; Carbohydrate Metabolism; Pentose and glucuronate
interconversions [PATH:hsa00040]
Metabolism; Carbohydrate Metabolism; Fructose and mannose metabolism
[PATH:hsa00051]
Metabolism; Carbohydrate Metabolism; Galactose metabolism
[PATH:hsa00052]
Metabolism; Carbohydrate Metabolism; Pyruvate metabolism
[PATH:hsa00620]
Metabolism; Lipid Metabolism; Glycerolipid metabolism
[PATH:hsa00561]

SSDB

Motif Pfam: Aldo_ket_red
PROSITE: ALDOKETO_REDUCTASE_2 ALDOKETO_REDUCTASE_1
ALDOKETO_REDUCTASE_3

Other DBs NCBI-GI: 4502049
NCBI-GeneID: 231
OMIM: 103880
HGNC: 381
HPRD: 00071
Ensembl: ENSG00000085662
UniProt: P15121

Structure

PDB: 1US0 3BCJ 2QXW 2I16 2I17 2J8T 2PFH 2PF8
     2PEV 1PWM 1Z8A 3GHR 3GHS 2PZN 2AGT 1Z3N
     1T41 2FZD 3GHT 1PWL 3GHU 1X98 1X96 1X97
     2PDG 2IKG 1Z89 3DN5 2PDH 2PDL 2IKI 2FZ8
     2FZB 2PDI 2PDK 2PDU 2PDW 2PD9 2NVD 2IKH
     2IKJ 2PDF 2PDJ 2HVN 2HV5 2PD5 2PDB 2DUX
     2DUZ 2FZ9 2DV0 2PDP 2PDX 2PDY 2PDC 2NVC
     2HVO 1ADS 2PDN 2IS7 1EL3 2PDQ 2R24 2PDM
     2ACQ 2ACR 2ACS 2ACU 3G5E 1T40 1AZ1 1MAR
     2INE 2F2K 2IQ0 2INZ 2ISF 2IQD 2IPW 1XGD
     1ABN 1IEI 1EF3 1AZ2

Position 7q35

AA seq 316 aa
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

NT seq 951 nt +upstreamnt +downstreamnt
atggcaagccgtctcctgctcaacaacggcgccaagatgcccatcctggggttgggtacc
tggaagtcccctccagggcaggtgactgaggccgtgaaggtggccattgacgtcgggtac
cgccacatcgactgtgcccatgtgtaccagaatgagaatgaggtgggggtggccattcag
gagaagctcagggagcaggtggtgaagcgtgaggagctcttcatcgtcagcaagctgtgg
tgcacgtaccatgagaagggcctggtgaaaggagcctgccagaagacactcagcgacctg
aagctggactacctggacctctaccttattcactggccgactggctttaagcctgggaag
gaatttttcccattggatgagtcgggcaatgtggttcccagtgacaccaacattctggac
acgtgggcggccatggaagagctggtggatgaagggctggtgaaagctattggcatctcc
aacttcaaccatctccaggtggagatgatcttaaacaaacctggcttgaagtataagcct
gcagttaaccagattgagtgccacccatatctcactcaggagaagttaatccagtactgc
cagtccaaaggcatcgtggtgaccgcctacagccccctcggctctcctgacaggccctgg
gccaagcccgaggacccttctctcctggaggatcccaggatcaaggcgatcgcagccaag
cacaataaaactacagcccaggtcctgatccggttccccatgcagaggaacttggtggtg
atccccaagtctgtgacaccagaacgcattgctgagaactttaaggtctttgactttgaa
ctgagcagccaggatatgaccaccttactcagctacaacaggaactggagggtctgtgcc
ttgttgagctgtacctcccacaaggattaccccttccatgaagagttttga

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (3)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (84)   
   PDB (84)   
Protein domain (4)   
   Pfam (1)   
   PROSITE (3)   
All databases (131)

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