KEGG H.sapiens: 25902

Homo sapiens (human): 25902

Entry

25902 CDS H.sapiens

Gene name MTHFD1L

Definition methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
(EC:6.3.4.3)

Orthology K13402 monofunctional C1-tetrahydrofolate synthase, mitochondrial
[EC:6.3.4.3]

Pathway hsa00630 Glyoxylate and dicarboxylate metabolism
hsa00670 One carbon pool by folate
hsa01100 Metabolic pathways

Class Metabolism; Carbohydrate Metabolism; Glyoxylate and dicarboxylate
metabolism [PATH:hsa00630]
Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by
folate [PATH:hsa00670]

SSDB

Motif Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH FMN_red
PROSITE: FTHFS_2 FTHFS_1

Other DBs NCBI-GI: 36796743
NCBI-GeneID: 25902
OMIM: 611427
HGNC: 21055
HPRD: 09967
Ensembl: ENSG00000120254
UniProt: Q6UB35

Position 6q25.1

AA seq 978 aa
MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSS
CSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQEINQNLAE
EAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD
GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLF
QRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKV
GCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP
SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGI
TPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEE
FNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL
KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYR
QAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKD
AIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM
EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCN
LQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVD
LARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGF
GNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRP
CFYDIDLDTETEQVKGLF

NT seq 2937 nt +upstreamnt +downstreamnt
atgggcacgcgtctgccgctcgtcctgcgccagctccgccgcccgccccagcccccgggc
cctccgcgccgcctccgtgtgccctgtcgcgctagcagcggcggcggcggaggcggcggc
ggtggccgggagggcctgcttggacagcggcggccgcaggatggccaggcccggagcagc
tgcagccccggcggccgaacgcccgcggcgcgggactccatcgtcagagaagtcattcag
aattcaaaagaagttctaagtttattgcaagaaaaaaaccctgccttcaagccggttctt
gcaattatccaggcaggtgacgacaacttgatgcaggaaatcaaccagaatttggctgag
gaggctggtctgaacatcactcacatttgcctccctccagatagcagtgaagccgagatt
atagatgaaatcttaaagatcaatgaagataccagagtacatggccttgcccttcagatc
tctgagaacttgtttagcaacaaagtcctcaatgccttgaaaccagaaaaagatgtggat
ggagtaacagacataaacctggggaagctggtgcgaggggatgcccatgaatgttttgtt
tcacctgttgccaaagctgtaattgaacttcttgaaaaatcaggtgtcaacctagatgga
aagaagattttggtagtgggggcccatgggtctttggaagctgctctacaatgcctgttc
cagagaaaagggtccatgacaatgagcatccagtggaaaacacgccagcttcaaagcaag
cttcacgaggctgacattgtggtcctaggctcacctaagccagaagagattccccttact
tggatacaaccaggaactactgttctcaactgctcccatgacttcctgtcagggaaggtt
gggtgtggctctccaagaatacattttggtggactcattgaggaagatgatgtgattctc
cttgctgcagctctgcgaattcagaacatggtcagtagtggaaggagatggcttcgtgaa
cagcagcacaggcggtggagacttcactgcttgaaacttcagcctctctcccctgtgcca
agtgacattgagatttcaagaggacaaactccaaaagctgtggatgtccttgccaaggag
attggattgcttgcagatgaaattgaaatctatggcaaaagcaaagccaaagtacgtttg
tccgtgctagaaaggttaaaggatcaagcagatggaaaatacgtcttagttgctgggatc
acacccacccctcttggagaagggaagagcacagtcaccatcgggcttgtgcaggctctg
accgcacacctgaatgtcaactcctttgcctgcttgaggcagccttcccaaggaccgacg
tttggagtgaaaggaggagccgcgggtggtggatatgcccaggtcatccccatggaggag
ttcaaccttcacttgactggagacatccacgccatcaccgctgccaataacttgctggct
gccgccatcgacacgaggattcttcatgaaaacacgcaaacagataaggctctgtataat
cggctggttcctttagtgaatggtgtcagagaattttcagaaattcagcttgctcggcta
aaaaaactgggaataaataagactgatccgagcacactgacagaagaggaagtgagtaaa
tttgcccgtctcgacatcgacccatctaccatcacgtggcagagagtattggatacaaat
gaccgatttctacgaaaaataaccatcgggcagggaaacacagagaagggccattaccgg
caggcgcagtttgacatcgcagtggccagcgagatcatggcggtgctggccctgacggac
agcctcgcagacatgaaggcacggctgggaaggatggtggtggccagtgacaaaagcggg
cagcctgtgacagcagatgatttgggggtgacaggtgctttgacagttttgatgaaagat
gcaataaaaccaaacctgatgcagaccctggaagggacacctgtgttcgtgcatgcgggc
ccttttgctaacattgctcacggcaactcttcagtgttggctgataaaattgccctgaaa
ctggttggtgaagaaggatttgtagtgaccgaagctggctttggtgctgacatcggaatg
gagaaattcttcaacatcaagtgccgagcttccggcttggtgcccaacgtggttgtgtta
gtggcaacggtgcgagctctgaagatgcatggaggcgggccaagtgtaacggctggtgtt
cctcttaagaaagaatatacagaggagaacatccagctggtggcagacggctgctgtaac
ctccagaagcaaattcagatcactcagctctttggggttcccgttgtggtggctctgaat
gtcttcaagaccgacacccgcgctgagattgacttggtgtgtgagcttgcaaagcgggct
ggtgcctttgatgcagtcccctgctatcactggtccgttggtggaaaaggatcggtggac
ttggctcgggctgtgagagaggctgcgagtaaaagaagccgattccagttcctgtatgat
gttcaggttccaattgtggacaagataaggaccattgctcaggctgtctatggagccaaa
gatattgaactctctcctgaggcacaagccaaaatagatcgttacactcaacagggtttt
ggaaatttgcccatctgcatggcaaagacccacctttctctatctcaccaacctgacaaa
aaaggtgtgccaagggacttcatcttacctatcagtgacgtccgggccagcataggcgct
gggttcatttaccctttggtcggaacgatgagcaccatgccaggactgcccacccggccc
tgcttttatgacatagatcttgataccgaaacagaacaagttaaaggcttgttctaa

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (3)   
   NCBI-Gene (1)   
   NCBI-GI (19)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (12)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (10)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
Protein domain (6)   
   Pfam (4)   
   PROSITE (2)   
All databases (62)

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