KEGG H.sapiens: 2618

Homo sapiens (human): 2618

Entry

2618 CDS H.sapiens

Gene name GART

Definition phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole
synthetase (EC:2.1.2.2 6.3.3.1 6.3.4.13)

Orthology K11787 phosphoribosylamine--glycine ligase /
phosphoribosylglycinamide formyltransferase /
phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13
2.1.2.2 6.3.3.1]

Pathway hsa00230 Purine metabolism
hsa00670 One carbon pool by folate
hsa01100 Metabolic pathways

Class Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:hsa00230]
Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by
folate [PATH:hsa00670]

SSDB

Motif Pfam: GARS_A Formyl_trans_N GARS_N AIRS_C GARS_C AIRS ATP-grasp
CPSase_L_D2 ATP-grasp_2 ATP-grasp_3 Dala_Dala_lig_C RimK
PROSITE: GART GARS ATP_GRASP

Other DBs NCBI-GI: 4503915
NCBI-GeneID: 2618
OMIM: 138440
HGNC: 4163
HPRD: 00716
Ensembl: ENSG00000159131
UniProt: P22102

Structure

PDB: 1MEO 1NJS 1MEJ 1RC0 1ZLY 2V9Y 1RBQ 1RBY
1RBZ 1ZLX 1MEN 1RC1 1RBM 2QK4

Position 21q22.1; 21q22.11

AA seq 1010 aa
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQ
FCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
VGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
LIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIV
ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE

NT seq 3033 nt +upstreamnt +downstreamnt
atggcagcccgagtacttataattggcagtggaggaagggaacatacgctggcctggaaa
cttgcacagtctcatcatgtcaaacaagtgttggttgccccaggaaacgcaggcactgcc
tgctctgaaaagatttcaaataccgccatctcaatcagtgaccacactgcccttgctcaa
ttctgcaaagagaagaaaattgaatttgtagttgttggaccagaagcacctctggctgct
gggattgttgggaacctgaggtctgcaggagtgcaatgctttggcccaacagcagaagcg
gctcagttagagtccagcaaaaggtttgccaaagagtttatggacagacatggaatccca
accgcacaatggaaggctttcaccaaacctgaagaagcctgcagcttcattttgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctggaaaaggggtgattgtt
gcaaagagcaaagaagaggcctgcaaagctgtacaagagatcatgcaggagaaagccttt
ggggcagctggagaaacaattgtcattgaagaacttcttgacggagaagaggtgtcgtgt
ctgtgtttcactgatggcaagactgtggcccccatgcccccagcacaggaccataagcga
ttactggagggagatggtggccctaacacagggggaatgggagcctattgtccagcccct
caggtttctaatgatctattactaaaaattaaagatactgttcttcagaggacagtggat
ggcatgcagcaagagggtactccatatacaggtattctctatgctggaataatgctgacc
aagaatggcccaaaagttctagagtttaattgccgttttggtgatccagagtgccaagta
atcctcccacttcttaaaagtgatctttatgaagtgattcagtccaccttagatggactg
ctctgcacatctctgcctgtttggctagaaaaccacaccgccctaactgttgtcatggca
agtaaaggttatcctggagactacaccaagggtgtagagataacagggtttcctgaggct
caagctctaggactggaggtgttccatgcaggcactgccctcaaaaatggcaaagtagta
actcatgggggtagagttcttgcagtcacagccatccgggaaaatctcatatcagccctt
gaggaagccaagaaaggactagctgctataaagtttgagggagcaatttataggaaagac
gtcggctttcgtgccatagctttcctccagcagcccaggagtttgacttacaaggaatct
ggagtagatatcgcagctggaaatatgctggtcaagaaaattcagcctttagcaaaagcc
acttccagatcaggctgtaaagttgatcttggaggttttgctggtctttttgatttaaaa
gcagctggtttcaaagatccccttctggcctctggaacagatggcgttggaactaaacta
aagattgcccagctatgcaataaacatgataccattggtcaagatttggtagcaatgtgt
gttaatgatattctggcacaaggagcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcagtgtaactgaagctgttgttgctggaattgctaaagcttgtgga
aaagctggatgtgctctccttggaggtgaaacagcagaaatgcctgacatgtatccccct
ggagagtatgacctagctgggtttgccgttggtgccatggagcgagatcagaaactccct
cacctggaaagaatcactgagggtgatgttgttgttggaatagcttcatctggtcttcat
agcaatggatttagccttgtgaggaaaatcgtggcaaaatcttccctccagtactcctct
ccagcacctgatggttgtggtgaccagactttaggggacttacttctcacgcctaccaga
atctacagccattcactgttacctgtcctacgttcaggacatgtcaaagcctttgcccat
attactggtggaggattactagagaacatccccagagtcctccctgagaaacttggggta
gatttagatgcccagacctggaggatccccagggtcttctcatggttgcagcaggaagga
cacctctctgaggaagagatggccagaacatttaactgtggggttggcgctgtccttgtg
gtatcaaaggagcagacagagcagattctgagggatatccagcagcacaaggaagaagcc
tgggtgattggcagtgtggttgcacgagctgaaggttccccacgtgtgaaagtcaagaat
ctgattgaaagcatgcaaataaatgggtcagtgttgaagaatggctccctgacaaatcat
ttctcttttgaaaaaaaaaaggccagagtggctgtcttaatatctggaacaggatcgaac
ctgcaagcacttatagacagtactcgggaaccaaatagctctgcacaaattgatattgtt
atctccaacaaagccgcagtagctgggttagataaagcggaaagagctggtattcccact
agagtaattaatcataaactgtataaaaatcgtgtagaatttgacagtgcaattgaccta
gtccttgaagagttctccatagacatagtctgtcttgcaggattcatgagaattctttct
ggcccctttgtccaaaagtggaatggaaaaatgctcaatatccacccatccttgctccct
tcttttaagggttcaaatgcccatgagcaagccctggaaaccggagtcacagttactggg
tgcactgtacactttgtagctgaagatgtggatgctggacagattattttgcaagaagct
gttcccgtgaagaggggtgatactgtcgcaactctttctgaaagagtaaaattagcagaa
cataaaatatttcctgcagcccttcagctggtggccagtggaactgtacagcttggagaa
aatggcaagatctgttgggttaaagaggaatga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (4)   
   KEGG DRUG (4)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (16)   
   UniProt (1)   
   RefSeq(pep) (4)   
   IPI (11)   
DNA sequence (14)   
   RefSeq(nuc) (4)   
   GenBank (5)   
   EMBL (5)   
3D Structure (14)   
   PDB (14)   
Protein domain (15)   
   Pfam (12)   
   PROSITE (3)   
All databases (85)

DBGET integrated database retrieval system