KEGG H.sapiens: 275

Homo sapiens (human): 275

Entry

275 CDS H.sapiens

Gene name AMT

Definition aminomethyltransferase (EC:2.1.2.10)

Orthology K00605 aminomethyltransferase [EC:2.1.2.10]

Pathway hsa00260 Glycine, serine and threonine metabolism
hsa00670 One carbon pool by folate
hsa00910 Nitrogen metabolism
hsa01100 Metabolic pathways

Disease H00191 Nonketotic hyperglycinemia

Class Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:hsa00910]
Metabolism; Amino Acid Metabolism; Glycine, serine and threonine
metabolism [PATH:hsa00260]
Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by
folate [PATH:hsa00670]

SSDB

Motif Pfam: GCV_T GCV_T_C

Other DBs NCBI-GI: 44662838
NCBI-GeneID: 275
OMIM: 238310
HGNC: 473
HPRD: 01997
Ensembl: ENSG00000145020
UniProt: A8K3I5 P48728

Structure

PDB: 1WSR 1WSV

Position 3p21.2-p21.1

AA seq 403 aa
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK

NT seq 1212 nt +upstreamnt +downstreamnt
atgcagagggctgtaagtgtggtggcccgtctgggctttcgcctgcaggcattccccccg
gccttgtgtcgtccacttagttgcgcacaggaggtgctccgcaggacaccgctctatgac
ttccacctggcccacggcgggaaaatggtggcgtttgcgggttggagtctgccagtgcag
taccgggacagtcacactgactcgcacctgcacacacgccagcactgctcgctctttgac
gtgtctcatatgctgcagaccaagatacttggtagtgaccgggtgaagctgatggagagt
ctagtggttggagacattgcagagctaagaccaaaccaggggacactgtcgctgtttacc
aacgaggctggaggcatcttagatgacttgattgtaaccaatacttctgagggccacctg
tatgtggtgtccaacgctggctgctgggagaaagatttggccctcatgcaggacaaggtc
agggagcttcagaaccagggcagagatgtgggcctggaggtgttggataatgccctgcta
gctctgcaaggccccactgcagcccaggtactacaggccggcgtggcagatgacctgagg
aaactgcccttcatgaccagtgctgtgatggaggtgtttggcgtgtctggctgccgcgtg
acccgctgtggctacacaggagaggatggtgtggagatctcggtgccggtagcgggggca
gttcacctggcaacagctattctgaaaaacccagaggtgaagctggcagggctggcagcc
agggacagcctgcgcctggaggcaggcctctgcctgtatgggaatgacattgatgaacac
actacacctgtggagggcagcctcagttggacactggggaagcgccgccgagctgctatg
gacttccctggagccaaggtcattgttccccagctgaagggcagggtgcagcggaggcgt
gtggggttgatgtgtgagggggcccccatgcgggcacacagtcccatcctgaacatggag
ggtaccaagattggtactgtgactagtggctgcccctccccctctctgaagaagaatgtg
gcgatgggttatgtgccctgcgagtacagtcgtccagggacaatgctgctggtagaggtg
cggcggaagcagcagatggctgtagtcagcaagatgccctttgtgcccacaaactactat
accctcaagtga

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (17)   
   UniProt (3)   
   RefSeq(pep) (4)   
   IPI (10)   
DNA sequence (10)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (3)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (49)

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