KEGG H.sapiens: 3034

Homo sapiens (human): 3034

Entry

3034 CDS H.sapiens

Gene name HAL

Definition histidine ammonia-lyase (EC:4.3.1.3)

Orthology K01745 histidine ammonia-lyase [EC:4.3.1.3]

Pathway hsa00340 Histidine metabolism
hsa00910 Nitrogen metabolism
hsa01100 Metabolic pathways

Disease H00171 Histidinemia

Class Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:hsa00910]
Metabolism; Amino Acid Metabolism; Histidine metabolism
[PATH:hsa00340]

SSDB

Motif Pfam: PAL
PROSITE: PAL_HISTIDASE

Other DBs NCBI-GI: 4504333
NCBI-GeneID: 3034
OMIM: 609457
HGNC: 4806
HPRD: 07187
Ensembl: ENSG00000084110
UniProt: P42357

Position 12q22-q24.1

AA seq 657 aa
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKG
LGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDR
LTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPI
NKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRG
QIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
ELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL

NT seq 1974 nt +upstreamnt +downstreamnt
atgcccagatacacggtgcacgtacgtggggaatggctggcagtgccctgccaggacgcg
cagctcactgtgggctggctgggccgggaggccgtgaggcgctatatcaagaataagccc
gacaatggtggcttcacctccgtggatgacgcgcacttccttgtgcgccggtgcaagggc
ctgggcctgctggacaacgaggaccggctcgaggtggccctagagaacaacgagttcgtg
gaagtggttatagagggtgatgccatgtctcctgacttcattccatctcaaccagaagga
gtttatctatacagcaagtaccgggagcctgaaaagtacatcgagttagatggagaccgt
ctgaccacggaggatctggtcaacttgggaaagggacgctacaaaataaagctcacccca
acagctgagaagagggtgcagaaatccagggaggtcatagatagcatcataaaagagaaa
acagttgtttacggtattactacaggttttgggaaatttgccagaactgtaattcctatc
aataagctacaggagcttcaggtcaacttagtacgctcacattcttcaggtgttgggaaa
ccactaagtcctgagaggtgtcggatgctcttggctttaaggatcaatgtcttagccaaa
ggatacagtggcatttccctggagaccctcaaacaagtcatagaaatgtttaatgcctcc
tgcctgccctatgtcccagagaaaggaaccgttggtgccagtggagaccttgccccactc
tctcatcttgctcttgggctagttggagaagggaagatgtggtctccgaagagtggctgg
gctgatgctaaatacgtgctagaagcccatggattgaaaccagttattttaaaaccaaaa
gagggcctggcactcatcaatgggacgcagatgatcacatccctgggctgtgaagctgta
gagcgagccagtgctattgcacggcaggctgacattgtggcagccctgacccttgaggtg
ctgaagggcaccaccaaagcctttgacactgacattcatgctcttcgacctcaccgtggg
caaattgaagttgcttttcggtttcggtcactcttggactcagatcaccacccatcagaa
atagcagagagtcacaggttctgtgatcgcgtccaggatgcatacaccttgcgctgctgt
ccacaggtccatggtgtggtgaatgatacaatagcatttgtgaagaacatcattaccaca
gaactgaacagcgcaacagataatcctatggtctttgccaataggggagagacagtttct
ggaggaaacttccatggtgaatacccagccaaagccctagactacttggccattggcatc
catgaacttgctgcaatcagtgagagaagaatcgagcggctctgcaatccctccctcagt
gagctgcctgccttcctggtggctgaaggtggtctgaactctgggttcatgatagctcac
tgcacggcagcagcccttgtttctgagaacaaggctctgtgccatccctcgtctgttgac
tccctctccaccagcgcagccacggaggaccacgtctccatgggaggatgggcagcaagg
aaagccctcagggtcatcgagcatgtggagcaagtgctggccatcgagctccttgcagcc
tgccagggcatagagtttctacgtcccctgaaaacaaccactccgctggagaaggtctat
gacctggtgcgctctgttgtaaggccctggataaaagatcgcttcatggccccggacatc
gaggcagcccacaggctgctcctggagcagaaggtttgggaagtagctgctccatacatt
gaaaaatacagaatggagcatattccagaatcaagacctctttctccaacagccttttca
ctgcaatttctgcacaagaaatccaccaaaatcccggagtctgaggacctttaa

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (13)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (3)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
Protein domain (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (60)

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