KEGG H.sapiens: 3156

Homo sapiens (human): 3156

Entry

3156 CDS H.sapiens

Gene name HMGCR

Definition 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (EC:1.1.1.34)

Orthology K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]

Pathway hsa00900 Terpenoid backbone biosynthesis
hsa01100 Metabolic pathways

Class Metabolism; Biosynthesis of Secondary Metabolites; Terpenoid
backbone biosynthesis [PATH:hsa00900]

SSDB

Motif Pfam: HMG-CoA_red Sterol-sensing Patched
PROSITE: HMG_COA_REDUCTASE_1 HMG_COA_REDUCTASE_2 HMG_COA_REDUCTASE_3
SSD HMG_COA_REDUCTASE_4

Other DBs NCBI-GI: 4557643
NCBI-GeneID: 3156
OMIM: 142910
HGNC: 5006
HPRD: 00836
Ensembl: ENSG00000113161
UniProt: P04035

Structure

PDB: 3CCZ 2R4F 2Q6B 2Q6C 1DQA 3CD7 2Q1L 3CDA
     3CCW 1HW8 1HWL 1DQ8 3CCT 1HWK 3BGL 1HWJ
     3CDB 1HWI 1HW9 3CD5 3CD0 1DQ9

Position 5q13.3-q14

AA seq 888 aa
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

NT seq 2667 nt +upstreamnt +downstreamnt
atgttgtcaagactttttcgaatgcatggcctctttgtggcctcccatccctgggaagtc
atagtggggacagtgacactgaccatctgcatgatgtccatgaacatgtttactggtaac
aataagatctgtggttggaattatgaatgtccaaagtttgaagaggatgttttgagcagt
gacattataattctgacaataacacgatgcatagccatcctgtatatttacttccagttc
cagaatttacgtcaacttggatcaaaatatattttgggtattgctggccttttcacaatt
ttctcaagttttgtattcagtacagttgtcattcacttcttagacaaagaattgacaggc
ttgaatgaagctttgccctttttcctacttttgattgacctttccagagcaagcacatta
gcaaagtttgccctcagttccaactcacaggatgaagtaagggaaaatattgctcgtgga
atggcaattttaggtcctacgtttaccctcgatgctcttgttgaatgtcttgtgattgga
gttggtaccatgtcaggggtacgtcagcttgaaattatgtgctgctttggctgcatgtca
gttcttgccaactacttcgtgttcatgactttcttcccagcttgtgtgtccttggtatta
gagctttctcgggaaagccgcgagggtcgtccaatttggcagctcagccattttgcccga
gttttagaagaagaagaaaataagccgaatcctgtaactcagagggtcaagatgattatg
tctctaggcttggttcttgttcatgctcacagtcgctggatagctgatccttctcctcaa
aacagtacagcagatacttctaaggtttcattaggactggatgaaaatgtgtccaagaga
attgaaccaagtgtttccctctggcagttttatctctctaaaatgatcagcatggatatt
gaacaagttattaccctaagtttagctctccttctggctgtcaagtacatcttctttgaa
caaacagagacagaatctacactctcattaaaaaaccctatcacatctcctgtagtgaca
caaaagaaagtcccagacaattgttgtagacgtgaacctatgctggtcagaaataaccag
aaatgtgattcagtagaggaagagacagggataaaccgagaaagaaaagttgaggttata
aaacccttagtggctgaaacagataccccaaacagagctacatttgtggttggtaactcc
tccttactcgatacttcatcagtactggtgacacaggaacctgaaattgaacttcccagg
gaacctcggcctaatgaagaatgtctacagatacttgggaatgcagagaaaggtgcaaaa
ttccttagtgatgctgagatcatccagttagtcaatgctaagcatatcccagcctacaag
ttggaaactctgatggaaactcatgagcgtggtgtatctattcgccgacagttactttcc
aagaagctttcagaaccttcttctctccagtacctaccttacagggattataattactcc
ttggtgatgggagcttgttgtgagaatgttattggatatatgcccatccctgttggagtg
gcaggacccctttgcttagatgaaaaagaatttcaggttccaatggcaacaacagaaggt
tgtcttgtggccagcaccaatagaggctgcagagcaataggtcttggtggaggtgccagc
agccgagtccttgcagatgggatgactcgtggcccagttgtgcgtcttccacgtgcttgt
gactctgcagaagtgaaagcctggctcgaaacatctgaagggttcgcagtgataaaggag
gcatttgacagcactagcagatttgcacgtctacagaaacttcatacaagtatagctgga
cgcaacctttatatccgtttccagtccaggtcaggggatgccatggggatgaacatgatt
tcaaagggtacagagaaagcactttcaaaacttcacgagtatttccctgaaatgcagatt
ctagccgttagtggtaactattgtactgacaagaaacctgctgctataaattggatagag
ggaagaggaaaatctgttgtttgtgaagctgtcattccagccaaggttgtcagagaagta
ttaaagactaccacagaggctatgattgaggtcaacattaacaagaatttagtgggctct
gccatggctgggagcataggaggctacaacgcccatgcagcaaacattgtcaccgccatc
tacattgcctgtggacaggatgcagcacagaatgttggtagttcaaactgtattacttta
atggaagcaagtggtcccacaaatgaagatttatatatcagctgcaccatgccatctata
gagataggaacggtgggtggtgggaccaacctactacctcagcaagcctgtttgcagatg
ctaggtgttcaaggagcatgcaaagataatcctggggaaaatgcccggcagcttgcccga
attgtgtgtgggaccgtaatggctggggaattgtcacttatggcagcattggcagcagga
catcttgtcaaaagtcacatgattcacaacaggtcgaagatcaatttacaagacctccaa
ggagcttgcaccaagaagacagcctga

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (18)   
   KEGG DRUG (18)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UNIGENE (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (7)   
   UniProt (1)   
   RefSeq(pep) (2)   
   IPI (4)   
DNA sequence (10)   
   RefSeq(nuc) (2)   
   GenBank (4)   
   EMBL (4)   
3D Structure (22)   
   PDB (22)   
Protein domain (8)   
   Pfam (3)   
   PROSITE (5)   
All databases (83)

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