KEGG H.sapiens: 3158

Homo sapiens (human): 3158

Entry

3158 CDS H.sapiens

Gene name HMGCS2

Definition 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
(EC:2.3.3.10)

Orthology K01641 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]

Pathway hsa00072 Synthesis and degradation of ketone bodies
hsa00280 Valine, leucine and isoleucine degradation
hsa00650 Butanoate metabolism
hsa00900 Terpenoid backbone biosynthesis
hsa01100 Metabolic pathways
hsa03320 PPAR signaling pathway

Class Metabolism; Carbohydrate Metabolism; Butanoate metabolism
[PATH:hsa00650]
Metabolism; Lipid Metabolism; Synthesis and degradation of ketone
bodies [PATH:hsa00072]
Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine
degradation [PATH:hsa00280]
Metabolism; Biosynthesis of Secondary Metabolites; Terpenoid
backbone biosynthesis [PATH:hsa00900]

SSDB

Motif Pfam: HMG_CoA_synt_C HMG_CoA_synt_N U3_assoc_6
PROSITE: HMG_COA_SYNTHASE

Other DBs NCBI-GI: 260656028
NCBI-GeneID: 3158
OMIM: 600234
HGNC: 5008
HPRD: 02580
Ensembl: ENSG00000134240
UniProt: B7Z8R3

Structure

PDB: 2WYA

Position 1p13-p12

AA seq 466 aa
MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE
VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP
WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM
ESSSWDGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWK
QAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLK
LEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQEL
AGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTE
IMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV

NT seq 1401 nt +upstreamnt +downstreamnt
atgcagcgtctgttgactccagtgaagcgcattctgcaactgacaagagcggtgcaggaa
acctccctcacacctgctcgcctgctcccagtagcccaccaaaggttttctacagcctct
gctgtccccctggccaaaacagatacttggccaaaggacgtgggcatcctggccctggag
gtctacttcccagcccaatatgtggaccaaactgacctggagaagtataacaatgtggaa
gcaggaaagtatacagtgggcttgggccagacccgtatgggcttctgctcagtccaagag
gacatcaactccctgtgcctgacggtggtgcaacggctgatggagcgcatacagctccca
tgggactctgtgggcaggctggaagtaggcactgagaccatcattgacaagtccaaagct
gtcaaaacagtgctcatggaactcttccaggattcaggcaatactgatattgagggcata
gataccaccaatgcctgctacggtggtactgcctccctcttcaatgctgccaactggatg
gagtccagttcctgggatgggctgaggggaacccatatggagaatgtgtatgacttctac
aaaccaaatttggcctcggagtacccaatagtggatgggaagctttccatccagtgctac
ttgcgggccttggatcgatgttacacatcataccgtaaaaaaatccagaatcagtggaag
caagctggcagcgatcgacccttcacccttgacgatttacagtacatgatctttcataca
cccttttgcaagatggtccagaagtctctggctcgcctgatgttcaatgacttcctgtca
gccagcagtgacacacaaaccagcttatataaggggctggaggctttcggggggctaaag
ctggaagacacctacaccaacaaggacctggataaagcacttctaaaggcctctcaggac
atgttcgacaagaaaaccaaggcttccctttacctctccactcacaatgggaacatgtac
acctcatccctgtacgggtgcctggcctcgcttctgtcccaccactctgcccaagaactg
gctggctccaggattggtgccttctcttatggctctggtttagcagcaagtttcttttca
tttcgagtatcccaggatgctgctccaggctctcccctggacaagttggtgtccagcaca
tcagacctgccaaaacgcctagcctcccgaaagtgtgtgtctcctgaggagttcacagaa
ataatgaaccaaagagagcaattctaccataaggtgaatttctccccacctggtgacaca
aacagccttttcccaggtacttggtacctggagcgagtggacgagcagcatcgccgaaag
tatgcccggcgtcccgtctaa

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (6)   
   UniProt (2)   
   RefSeq(pep) (2)   
   IPI (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (3)   
   PROSITE (1)   
All databases (39)

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