KEGG   Homo sapiens (human): 3551Help
Entry
3551              CDS       T01001                                 

Gene name
IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Definition
(RefSeq) inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)
  KO
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Ras signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Module
Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    3551 (IKBKB)
   04010 MAPK signaling pathway
    3551 (IKBKB)
   04064 NF-kappa B signaling pathway
    3551 (IKBKB)
   04668 TNF signaling pathway
    3551 (IKBKB)
   04068 FoxO signaling pathway
    3551 (IKBKB)
   04151 PI3K-Akt signaling pathway
    3551 (IKBKB)
   04150 mTOR signaling pathway
    3551 (IKBKB)
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    3551 (IKBKB)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    3551 (IKBKB)
   04621 NOD-like receptor signaling pathway
    3551 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    3551 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    3551 (IKBKB)
   04660 T cell receptor signaling pathway
    3551 (IKBKB)
   04662 B cell receptor signaling pathway
    3551 (IKBKB)
   04062 Chemokine signaling pathway
    3551 (IKBKB)
  Endocrine system
   04910 Insulin signaling pathway
    3551 (IKBKB)
   04920 Adipocytokine signaling pathway
    3551 (IKBKB)
  Nervous system
   04722 Neurotrophin signaling pathway
    3551 (IKBKB)
  Development
   04380 Osteoclast differentiation
    3551 (IKBKB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3551 (IKBKB)
   05206 MicroRNAs in cancer
    3551 (IKBKB)
   05212 Pancreatic cancer
    3551 (IKBKB)
   05221 Acute myeloid leukemia
    3551 (IKBKB)
   05220 Chronic myeloid leukemia
    3551 (IKBKB)
   05215 Prostate cancer
    3551 (IKBKB)
   05222 Small cell lung cancer
    3551 (IKBKB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    3551 (IKBKB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    3551 (IKBKB)
   04931 Insulin resistance
    3551 (IKBKB)
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    3551 (IKBKB)
   05131 Shigellosis
    3551 (IKBKB)
   05166 HTLV-I infection
    3551 (IKBKB)
   05164 Influenza A
    3551 (IKBKB)
   05161 Hepatitis B
    3551 (IKBKB)
   05160 Hepatitis C
    3551 (IKBKB)
   05168 Herpes simplex infection
    3551 (IKBKB)
   05169 Epstein-Barr virus infection
    3551 (IKBKB)
   05145 Toxoplasmosis
    3551 (IKBKB)
   05142 Chagas disease (American trypanosomiasis)
    3551 (IKBKB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     3551 (IKBKB)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: Other group
  IKK family [OT]
   3551 (IKBKB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
8p11.2
AA seq 756 aa AA seqDB search
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
NT seq 2271 nt NT seq  +upstreamnt  +downstreamnt
atgagctggtcaccttccctgacaacgcagacatgtggggcctgggaaatgaaagagcgc
cttgggacagggggatttggaaatgtcatccgatggcacaatcaggaaacaggtgagcag
attgccatcaagcagtgccggcaggagctcagcccccggaaccgagagcggtggtgcctg
gagatccagatcatgagaaggctgacccaccccaatgtggtggctgcccgagatgtccct
gaggggatgcagaacttggcgcccaatgacctgcccctgctggccatggagtactgccaa
ggaggagatctccggaagtacctgaaccagtttgagaactgctgtggtctgcgggaaggt
gccatcctcaccttgctgagtgacattgcctctgcgcttagataccttcatgaaaacaga
atcatccatcgggatctaaagccagaaaacatcgtcctgcagcaaggagaacagaggtta
atacacaaaattattgacctaggatatgccaaggagctggatcagggcagtctttgcaca
tcattcgtggggaccctgcagtacctggccccagagctactggagcagcagaagtacaca
gtgaccgtcgactactggagcttcggcaccctggcctttgagtgcatcacgggcttccgg
cccttcctccccaactggcagcccgtgcagtggcattcaaaagtgcggcagaagagtgag
gtggacattgttgttagcgaagacttgaatggaacggtgaagttttcaagctctttaccc
taccccaataatcttaacagtgtcctggctgagcgactggagaagtggctgcaactgatg
ctgatgtggcacccccgacagaggggcacggatcccacgtatgggcccaatggctgcttc
aaggccctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacgggc
accatccacacctaccctgtgacagaggatgagagtctgcagagcttgaaggccagaatc
caacaggacacgggcatcccagaggaggaccaggagctgctgcaggaagcgggcctggcg
ttgatccccgataagcctgccactcagtgtatttcagacggcaagttaaatgagggccac
acattggacatggatcttgtttttctctttgacaacagtaaaatcacctatgagactcag
atctccccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaat
ctcgccttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagaccctg
aaggaagattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctccga
aacaacagctgcctctccaaaatgaagaattccatggcttccatgtctcagcagctcaag
gccaagttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgagcaa
accgagtttgggatcacatcagataaactgctgctggcctggagggaaatggagcaggct
gtggagctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggctctg
cagaccgacattgtggacttacagaggagccccatgggccggaagcaggggggaacgctg
gacgacctagaggagcaagcaagggagctgtacaggagactaagggaaaaacctcgagac
cagcgaactgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcagagc
ttcgagaagaaagtgcgagtgatctatacgcagctcagtaaaactgtggtttgcaagcag
aaggcgctggaactgttgcccaaggtggaagaggtggtgagcttaatgaatgaggatgag
aagactgttgtccggctgcaggagaagcggcagaaggagctctggaatctcctgaagatt
gcttgtagcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctctcga
cttagccagcctgggcagctgatgtctcagccctccacggcctccaacagcttacctgag
ccagccaagaagagtgaagaactggtggctgaagcacataacctctgcaccctgctagaa
aatgccatacaggacactgtgagggaacaagaccagagtttcacggccctagactggagc
tggttacagacggaagaagaagagcacagctgcctggagcaggcctcatga

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