KEGG H.sapiens: 3615

Homo sapiens (human): 3615

Entry

3615 CDS H.sapiens

Gene name IMPDH2

Definition IMP (inosine monophosphate) dehydrogenase 2 (EC:1.1.1.205)

Orthology K00088 IMP dehydrogenase [EC:1.1.1.205]

Pathway hsa00230 Purine metabolism
hsa00983 Drug metabolism - other enzymes
hsa01100 Metabolic pathways

Class Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:hsa00230]
Metabolism; Xenobiotics Biodegradation and Metabolism; Drug
metabolism - other enzymes [PATH:hsa00983]

SSDB

Motif Pfam: IMPDH CBS NPD FMN_dh His_biosynth NanE ThiG Dus B12-binding
Glu_synthase Response_reg DUF561 Aldolase
PROSITE: IMP_DH_GMP_RED

Other DBs NCBI-GI: 66933016
NCBI-GeneID: 3615
OMIM: 146691
HGNC: 6053
HPRD: 00895
Ensembl: ENSG00000178035
UniProt: P12268

Structure

PDB: 1NF7 1NFB 1B3O

Position 3p21.2

AA seq 514 aa
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

NT seq 1545 nt +upstreamnt +downstreamnt
atggccgactacctgattagtgggggcacgtcctacgtgccagacgacggactcacagca
cagcagctcttcaactgcggagacggcctcacctacaatgactttctcattctccctggg
tacatcgacttcactgcagaccaggtggacctgacttctgctctgaccaagaaaatcact
cttaagaccccactggtttcctctcccatggacacagtcacagaggctgggatggccata
gcaatggcgcttacaggcggtattggcttcatccaccacaactgtacacctgaattccag
gccaatgaagttcggaaagtgaagaaatatgaacagggattcatcacagaccctgtggtc
ctcagccccaaggatcgcgtgcgggatgtttttgaggccaaggcccggcatggtttctgc
ggtatcccaatcacagacacaggccggatggggagccgcttggtgggcatcatctcctcc
agggacattgattttctcaaagaggaggaacatgactgtttcttggaagagataatgaca
aagagggaagacttggtggtagcccctgcaggcatcacactgaaggaggcaaatgaaatt
ctgcagcgcagcaagaagggaaagttgcccattgtaaatgaagatgatgagcttgtggcc
atcattgcccggacagacctgaagaagaatcgggactacccactagcctccaaagatgcc
aagaaacagctgctgtgtggggcagccattggcactcatgaggatgacaagtataggctg
gacttgctcgcccaggctggtgtggatgtagtggttttggactcttcccagggaaattcc
atcttccagatcaatatgatcaagtacatcaaagacaaataccctaatctccaagtcatt
ggaggcaatgtggtcactgctgcccaggccaagaacctcattgatgcaggtgtggatgcc
ctgcgggtgggcatgggaagtggctccatctgcattacgcaggaagtgctggcctgtggg
cggccccaagcaacagcagtgtacaaggtgtcagagtatgcacggcgctttggtgttccg
gtcattgctgatggaggaatccaaaatgtgggtcatattgcgaaagccttggcccttggg
gcctccacagtcatgatgggctctctcctggctgccaccactgaggcccctggtgaatac
ttcttttccgatgggatccggctaaagaaatatcgcggtatgggttctctcgatgccatg
gacaagcacctcagcagccagaacagatatttcagtgaagctgacaaaatcaaagtggcc
cagggagtgtctggtgctgtgcaggacaaagggtcaatccacaaatttgtcccttacctg
attgctggcatccaacactcatgccaggacattggtgccaagagcttgacccaagtccga
gccatgatgtactctggggagcttaagtttgagaagagaacgtcctcagcccaggtggaa
ggtggcgtccatagcctccattcgtatgagaagcggcttttctga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (9)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (7)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (3)   
   PDB (3)   
Protein domain (14)   
   Pfam (13)   
   PROSITE (1)   
All databases (61)

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