KEGG H.sapiens: 3712

Homo sapiens (human): 3712

Entry

3712 CDS H.sapiens

Gene name IVD

Definition isovaleryl Coenzyme A dehydrogenase (EC:1.3.99.10)

Orthology K00253 isovaleryl-CoA dehydrogenase [EC:1.3.99.10]

Pathway hsa00280 Valine, leucine and isoleucine degradation
hsa01100 Metabolic pathways

Disease H00173 Isovaleric acidemia (IVA)

Class Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine
degradation [PATH:hsa00280]

SSDB

Motif Pfam: Acyl-CoA_dh_1 Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_2
PROSITE: ACYL_COA_DH_2 ACYL_COA_DH_1

Other DBs NCBI-GI: 226958414
NCBI-GeneID: 3712
OMIM: 607036
HGNC: 6186
HPRD: 09516
Ensembl: ENSG00000128928
UniProt: B3KVI7

Structure

PDB: 1IVH

Position 15q14-q15

AA seq 396 aa
MAEMATATRLLGWRVASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQEFWKQLGNL
GVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKE
KYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIV
YAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILG
HENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMA
DMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYIND
FPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH

NT seq 1191 nt +upstreamnt +downstreamnt
atggcagagatggcgactgcgactcggctgctggggtggcgtgtggcgagctggaggctg
cggccgccgcttgccggcttcgtttcccagcgggcccactcgcttttgcccgtggacgat
gcaatcaatgggctaagcgaggagcagaggcaggaattttggaagcagctggggaacctg
ggcgtattgggcatcacagcccctgttcagtatggcggctccggcctgggctacctggag
catgtgctggtgatggaggagatatcccgagcttccggagcagtggggctcagttacggt
gcccactccaacctctgcatcaaccagcttgtacgcaatgggaatgaggcccagaaagag
aagtatctcccgaagctgatcagtggtgagtacatcggagccctggccatgagtgagccc
aatgcaggctctgatgttgtctctatgaagctcaaagcggaaaagaaaggaaatcactac
atcctgaatggcaacaagttctggatcactaatggccctgatgctgacgtcctgattgtc
tatgccaagacagatctggctgctgtgccagcttctcggggcatcacagccttcattgtg
gagaagggtatgcctggctttagcacctctaagaagctggacaagctggggatgaggggc
tctaacacctgtgagctaatctttgaagactgcaagattcctgctgccaacatcctgggc
catgagaataagggtgtctacgtgctgatgagtgggctggacctggagcggctggtgctg
gccggggggcctcttgggctcatgcaagcggtcctggaccacaccattccctacctgcac
gtgagggaagcctttggccagaagatcggccacttccagttgatgcaggggaagatggct
gacatgtacacccgcctcatggcgtgtcggcagtatgtctacaatgtcgccaaggcctgc
gatgagggccattgcactgctaaggactgtgcaggtgtgattctttactcagctgagtgt
gccacacaggtagccctggacggcattcagtgttttggtggcaatggctacatcaatgac
tttcccatgggccgctttcttcgagatgccaagctgtatgagataggggctgggaccagc
gaggtgaggcggctggtcatcggcagagccttcaatgcagactttcactag

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (10)   
   UniProt (2)   
   RefSeq(pep) (2)   
   IPI (6)   
DNA sequence (12)   
   RefSeq(nuc) (2)   
   GenBank (5)   
   EMBL (5)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   Pfam (4)   
   PROSITE (2)   
All databases (48)

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