KEGG H.sapiens: 3735

Homo sapiens (human): 3735

Entry

3735 CDS H.sapiens

Gene name KARS

Definition lysyl-tRNA synthetase (EC:6.1.1.6)

Orthology K04567 lysyl-tRNA synthetase, class II [EC:6.1.1.6]

Pathway hsa00970 Aminoacyl-tRNA biosynthesis

Class Genetic Information Processing; Translation; Aminoacyl-tRNA
biosynthesis [PATH:hsa00970]

SSDB

Motif Pfam: tRNA-synt_2 tRNA_anti tRNA-synt_2d tRNA-synt_2b Dec-1 DUF2070
PROSITE: AA_TRNA_LIGASE_II

Other DBs NCBI-GI: 194272210
NCBI-GeneID: 3735
OMIM: 601421
HGNC: 6215
HPRD: 03249
Ensembl: ENSG00000065427

Structure

PDB: 3BJU

Position 16q23-q24

AA seq 625 aa
MLTQAAVRLVRGSLRKTSWAEWGHRELRLGQLAPFTAPHKDKSFSDQRSELKRRLKAEKK
VAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGE
DPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGV
KLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHM
LPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN
IIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHN
PEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFR
RINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFL
EVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLF
EEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPA
MKPEDKKENVATTDTLESTTVGTSV

NT seq 1878 nt +upstreamnt +downstreamnt
atgttgacgcaagctgctgtaaggcttgttagggggtccctgcgcaaaacctcctgggca
gagtggggtcacagggaactgcgactgggtcaacttgctcctttcacagcgcctcacaag
gacaagtcattttctgatcaaagaagtgagctgaagagacgcctgaaagctgagaagaaa
gtagcagagaaggaggccaaacagaaagagctcagtgagaaacagctaagccaagccact
gctgctgccaccaaccacaccactgataatggtgtgggtcctgaggaagagagcgtggac
ccaaatcaatactacaaaatccgcagtcaagcaattcatcagctgaaggtcaatggggaa
gacccatacccacacaagttccatgtagacatctcactcactgacttcatccaaaaatat
agtcacctgcagcctggggatcacctgactgacatcaccttaaaggtggcaggtaggatc
catgccaaaagagcttctgggggaaagctcatcttctatgatcttcgaggagagggggtg
aagttgcaagtcatggccaattccagaaattataaatcagaagaagaatttattcatatt
aataacaaactgcgtcggggagacataattggagttcaggggaatcctggtaaaaccaag
aagggtgagctgagcatcattccgtatgagatcacactgctgtctccctgtttgcatatg
ttacctcatcttcactttggcctcaaagacaaggaaacaaggtatcgccagagatacttg
gacttgatcctgaatgactttgtgaggcagaaatttatcatccgctctaagatcatcaca
tatataagaagtttcttagatgagctgggattcctagagattgaaactcccatgatgaac
atcatcccagggggagccgtggccaagcctttcatcacttatcacaacgagctggacatg
aacttatatatgagaattgctccagaactctatcataagatgcttgtggttggtggcatc
gaccgggtttatgaaattggacgccagttccggaatgaggggattgatttgacgcacaat
cctgagttcaccacctgtgagttctacatggcctatgcagactatcacgatctcatggaa
atcacggagaagatggtttcagggatggtgaagcatattacaggcagttacaaggtcacc
taccacccagatggcccagagggccaagcctacgatgttgacttcaccccacccttccgg
cgaatcaacatggtagaagagcttgagaaagccctggggatgaagctgccagaaacgaac
ctctttgaaactgaagaaactcgcaaaattcttgatgatatctgtgtggcaaaagctgtt
gaatgccctccacctcggaccacagccaggctccttgacaagcttgttggggagttcctg
gaagtgacttgcatcaatcctacattcatctgtgatcacccacagataatgagccctttg
gctaaatggcaccgctctaaagagggtctgactgagcgctttgagctgtttgtcatgaag
aaagagatatgcaatgcgtatactgagctgaatgatcccatgcggcagcggcagcttttt
gaagaacaggccaaggccaaggctgcaggtgatgatgaggccatgttcatagatgaaaac
ttctgtactgccctggaatatgggctgccccccacagctggctggggcatgggcattgat
cgagtcgccatgtttctcacggactccaacaacatcaaggaagtacttctgtttcctgcc
atgaaacccgaagacaagaaggagaatgtagcaaccactgatacactggaaagcacaaca
gttggcacttctgtctag

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (5)   
   RefSeq(pep) (2)   
   IPI (3)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (7)   
   Pfam (6)   
   PROSITE (1)   
All databases (36)

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