KEGG H.sapiens: 3938

Homo sapiens (human): 3938

Entry

3938 CDS H.sapiens

Gene name LCT

Definition lactase (EC:3.2.1.108 3.2.1.62)

Orthology K01229 lactase-phlorizin hydrolase [EC:3.2.1.108 3.2.1.62]

Pathway hsa00052 Galactose metabolism

Disease H00116 Congenital lactase deficiency

Class Metabolism; Carbohydrate Metabolism; Galactose metabolism
[PATH:hsa00052]
Genetic Information Processing; Folding, Sorting and Degradation;
Chaperones and folding catalysts

SSDB

Motif Pfam: Glyco_hydro_1
PROSITE: GLYCOSYL_HYDROL_F1_1 GLYCOSYL_HYDROL_F1_2
PROKAR_LIPOPROTEIN

Other DBs NCBI-GI: 32481206
NCBI-GeneID: 3938
OMIM: 603202
HGNC: 6530
HPRD: 04437
Ensembl: ENSG00000115850
UniProt: P09848 Q4ZG58

Position 2q21

AA seq 1927 aa
MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
RIWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
PGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSPVSSF

NT seq 5784 nt +upstreamnt +downstreamnt
atggagctgtcttggcatgtagtctttattgccctgctaagtttttcatgctgggggtca
gactgggagtctgatagaaatttcatttccaccgctggtcctctaaccaatgacttgctg
cacaacctgagtggtctcctgggagaccagagttctaactttgtagcaggggacaaagac
atgtatgtttgtcaccagccactgcccactttcctgccagaatacttcagcagtctccat
gccagtcagatcacccattataaggtatttctgtcatgggcacagctcctcccagcagga
agcacccagaatccagacgagaaaacagtgcagtgctaccggcgactcctcaaggccctc
aagactgcacggcttcagcccatggtcatcctgcaccaccagaccctccctgccagcacc
ctccggagaaccgaagcctttgctgacctcttcgccgactatgccacattcgccttccac
tccttcggggacctagttgggatctggttcaccttcagtgacttggaggaagtgatcaag
gagcttccccaccaggaatcaagagcgtcacaactccagaccctcagtgatgcccacaga
aaagcctatgagatttaccacgaaagctatgcttttcagggcggaaaactctctgttgtc
ctgcgagctgaagatatcccggagctcctgctagaaccacccatatctgcgcttgcccag
gacacggtcgatttcctctctcttgatttgtcttatgaatgccaaaatgaggcaagtctg
cggcagaagctgagtaaattgcagaccattgagccaaaagtgaaagttttcatcttcaac
ctaaaactcccagactgcccctccaccatgaagaacccagccagtctgctcttcagcctt
tttgaagccataaataaagaccaagtgctcaccattgggtttgatattaatgagtttctg
agttgttcatcaagttccaagaaaagcatgtcttgttctctgactggcagcctggccctt
cagcctgaccagcagcaggaccacgagaccacggactcctctcctgcctctgcctatcag
agaatctgggaagcatttgccaatcagtccagggcggaaagggatgccttcctgcaggat
actttccctgaaggcttcctctggggtgcctccacaggagcctttaacgtggaaggaggc
tgggccgagggtgggagaggggtgagcatctgggatccacgcaggcccctgaacaccact
gagggccaagcgacgctggaggtggccagcgacagttaccacaaggtagcctctgacgtc
gccctgctttgcggcctccgggctcaggtgtacaagttctccatctcctggtcccggatc
ttccccatggggcacgggagcagccccagcctcccaggcgttgcctactacaacaagctg
attgacaggctacaggatgcgggcatcgagcccatggccacgctgttccactgggacctg
cctcaggccctgcaggatcatggtggatggcagaatgagagcgtggtggatgccttcctg
gactatgcggccttctgcttctccacatttggggaccgtgtgaagctgtgggtgaccttc
catgagccgtgggtgatgagctacgcaggctatggcaccggccagcaccctcccggcatc
tctgacccaggagtggcctcttttaaggtggctcacttggtcctcaaggctcatgccaga
acttggcaccactacaacagccatcatcgcccacagcagcaggggcacgtgggcattgtg
ctgaactcagactgggcagaacccctgtctccagagaggcctgaggacctgagagcctct
gagcgcttcttgcacttcatgctgggctggtttgcacaccccgtctttgtggatggagac
tacccagccaccctgaggacccagatccaacagatgaacagacagtgctcccatcctgtg
gctcaactccccgagttcacagaggcagagaagcagctcctgaaaggctctgctgatttt
ctgggtctgtcgcattacacctcccgcctcatcagcaacgccccacaaaacacctgcatc
cctagctatgataccattggaggcttctcccaacacgtgaaccatgtgtggccccagacc
tcatcctcttggattcgtgtggtgccctgggggataaggaggctgttgcagtttgtatcc
ctggaatacacaagaggaaaagttccaatataccttgccgggaatggcatgcccataggg
gaaagtgaaaatctctttgatgattccttaagagtagactacttcaatcaatatatcaat
gaggtgctcaaggctatcaaggaagactctgtggatgttcgttcctacattgctcgttcc
ctcattgatggcttcgaaggcccttctggttacagccagcggtttggcctgcaccacgtc
aacttcagcgacagcagcaagtcaaggactcccaggaaatctgcctactttttcactagc
atcatagaaaagaacggtttcctcaccaagggggcaaaaagactgctaccacctaataca
gtaaacctcccctccaaagtcagagccttcacttttccatctgaggtgccctccaaggct
aaagtcgtttgggaaaagttctccagccaacccaagttcgaaagagatttgttctaccac
gggacgtttcgggatgactttctgtggggcgtgtcctcttccgcttatcagattgaaggc
gcgtgggatgccgatggcaaaggccccagcatctgggataactttacccacacaccaggg
agcaatgtgaaagacaatgccactggagacatcgcctgtgacagctatcaccagctggat
gccgatctgaatatgctccgagctttgaaggtgaaggcctaccgcttctctatctcctgg
tctcggattttcccaactgggagaaacagctctatcaacagtcatggggttgattattac
aacaggctgatcaatggcttggtggcaagcaacatctttcccatggtgacattgttccat
tgggacctgccccaggccctccaggatatcggaggctgggagaatcctgccttgattgac
ttgtttgacagctacgcagacttttgtttccagacctttggtgatagagtcaagttttgg
atgacttttaatgagcccatgtacctggcatggctaggttatggctcaggggaatttccc
ccaggggtgaaggacccaggctgggcaccatataggatagcccacgccgtcatcaaagcc
catgccagagtctatcacacgtacgatgagaaatacaggcaggagcagaagggggtcatc
tcgctgagcctcagtacacactgggcagagcccaagtcaccaggggtccccagagatgtg
gaagccgctgaccgaatgctgcagttctccctgggctggtttgctcaccccatttttaga
aacggagactatcctgacaccatgaagtggaaagtggggaacaggagtgaactgcagcac
ttagccacctcccgcctgccaagcttcactgaggaagagaagaggttcatcagggcgacg
gccgacgtcttctgcctcaacacgtactactccagaatcgtgcagcacaaaacacccagg
ctaaacccaccctcctacgaagacgaccaggagatggctgaggaggaggacccttcgtgg
ccttccacggcaatgaacagagctgcgccctgggggacgcgaaggctgctgaactggatc
aaggaagagtatggtgacatccccatttacatcaccgaaaacggagtggggctgaccaat
ccgaacacggaggatactgataggatattttaccacaaaacctacatcaatgaggctttg
aaagcctacaggctcgatggtatagaccttcgagggtatgtcgcctggtctctgatggac
aactttgagtggctaaatggctacacggtcaagtttggactgtaccatgttgatttcaac
aacacgaacaggcctcgcacagcaagagcctccgccaggtactacacagaggtcattacc
aacaacggcatgccactggccagggaggatgagtttctgtacggacggtttcctgagggc
ttcatctggagtgcagcttctgctgcatatcagattgaaggtgcgtggagagcagatggc
aaaggactcagcatttgggacacgttttctcacacaccactgagggttgagaacgatgcc
attggagacgtggcctgtgacagttatcacaagattgctgaggatctggtcaccctgcag
aacctgggcgtgtcccactaccgtttttccatctcctggtctcgcatcctccctgatgga
accaccaggtacatcaatgaagcgggcctgaactactacgtgaggctcatcgatacactg
ctggccgccagcatccagccccaggtgaccatttaccactgggacctaccacagacgctc
caagatgtaggaggctgggagaatgagaccatcgtgcagcggtttaaggagtatgcagat
gtgctcttccagaggctgggagacaaggtgaagttttggatcacgctgaatgagcccttt
gtcattgcttaccagggctatggctacggaacagcagctccaggagtctccaataggcct
ggcactgccccctacattgttggccacaatctaataaaggctcatgctgaggcctggcat
ctgtacaacgatgtgtaccgcgccagtcaaggtggcgtgatttccatcaccatcagcagt
gactgggctgaacccagagatccctctaaccaggaggatgtggaggcagccaggagatat
gttcagttcatgggaggctggtttgcacatcctattttcaagaatggagattacaatgag
gtgatgaagacgcggatccgtgacaggagcttggctgcaggcctcaacaagtctcggctg
ccagaatttacagagagtgagaagaggaggatcaacggcacctatgacttttttgggttc
aatcactacaccactgtcctcgcctacaacctcaactatgccactgccatctcttctttt
gatgcagacagaggagttgcttccatcgcagatcgctcgtggccagactctggctccttc
tggctgaagatgacgccttttggcttcaggaggatcctgaactggttaaaggaggaatac
aatgaccctccaatttatgtcacagagaatggagtgtcccagcgggaagaaacagacctc
aatgacactgcaaggatctactaccttcggacttacatcaatgaggccctcaaagctgtg
caggacaaggtggaccttcgaggatacacagtttggagtgcgatggacaattttgagtgg
gccacaggcttttcagagagatttggtctgcattttgtgaactacagtgacccttctctg
ccaaggatccccaaagcatcagcgaagttctacgcctctgtggtccgatgcaatggcttc
cctgaccccgctacagggcctcacgcttgtctccaccagccagatgctggacccaccatc
agccccgtgagacaggaggaggtgcagttcctggggctaatgctcggcaccacagaagca
cagacagctttgtacgttctcttttctcttgtgcttcttggagtctgtggcttggcattt
ctgtcatacaagtactgcaagcgctctaagcaagggaaaacacaacgaagccaacaggaa
ttgagcccggtgtcttcattctga

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (6)   
   UniProt (2)   
   RefSeq(pep) (1)   
   IPI (3)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (4)   
   Pfam (1)   
   PROSITE (3)   
All databases (41)

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