KEGG H.sapiens: 4047

Homo sapiens (human): 4047

Entry

4047 CDS H.sapiens

Gene name LSS

Definition lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
(EC:5.4.99.7)

Orthology K01852 lanosterol synthase [EC:5.4.99.7]

Pathway hsa00100 Steroid biosynthesis
hsa01100 Metabolic pathways

Class Metabolism; Lipid Metabolism; Steroid biosynthesis [PATH:hsa00100]

SSDB

Motif Pfam: Prenyltrans Pec_lyase A2M_comp
PROSITE: TERPENE_SYNTHASES

Other DBs NCBI-GI: 47933397
NCBI-GeneID: 4047
OMIM: 600909
HGNC: 6708
HPRD: 02945
Ensembl: ENSG00000160285
UniProt: B2R694 P48449

Structure

PDB: 1W6K 1W6J

Position 21q22.3

AA seq 732 aa
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP

NT seq 2199 nt +upstreamnt +downstreamnt
atgacggagggcacgtgtctgcggcgccgagggggcccctacaagaccgagcccgccacc
gacctcggccgctggcgactcaactgcgagaggggccggcagacgtggacctacctgcag
gacgagcgcgccggccgcgagcagaccggcctggaagcctacgccctggggctggacacc
aagaattactttaaggacttgcccaaagcccacaccgcctttgagggggctctgaacggg
atgacattttacgtggggctgcaggctgaggatgggcactggacgggtgattatggtggc
ccacttttcctcctgccaggcctcctgatcacttgccacgtggcacgcatccctctgcca
gccggatacagagaagagattgtgcggtacctgcggtcagtgcagctccctgacggtggc
tggggcctgcacattgaggataagtccaccgtgtttgggactgcgctcaactatgtgtct
ctcagaattctgggtgttgggcctgacgatcctgacctggtacgagcccggaacattctt
cacaagaaaggtggtgctgtggccatcccctcctgggggaagttctggctggctgtcctg
aatgtttacagctgggaaggcctcaataccctgttcccagagatgtggctgtttcctgac
tgggcaccggcacacccctccacactctggtgccactgccggcaggtgtacctgcccatg
agctactgctacgccgttcggctgagtgccgcggaagacccgctggtccagagcctccgc
caggagctctatgtggaggacttcgccagcattgactggctggcgcagaggaacaacgtg
gcccccgacgagctgtacacgccgcacagctggctgctccgcgtggtatatgcgctcctc
aacctgtatgagcaccaccacagtgcccacctgcggcagcgggccgtgcagaagctgtat
gaacacattgtggccgacgaccgattcaccaagagcatcagcatcggcccgatctcgaaa
accatcaacatgcttgtgcgctggtatgtggacgggcccgcctccactgccttccaggag
catgtctccagaatcccggactatctctggatgggccttgacggcatgaaaatgcagggc
accaacggctcacagatctgggacaccgcattcgccatccaggctctgcttgaggcgggc
gggcaccacaggcccgagttttcgtcctgcctgcagaaggctcatgagttcctgaggctc
tcacaggtcccagataaccctcccgactaccagaagtactaccgccagatgcgcaagggt
ggcttctccttcagtacgctggactgcggctggatcgtttctgactgcacggctgaggcc
ttgaaggctgtgctgctcctgcaggagaagtgtccccatgtcaccgagcacatccccaga
gaacggctctgcgatgctgtggctgtgctgctgaacatgagaaatccagatggagggttc
gccacctatgagaccaagcgtggggggcacttgctggagctgctgaacccctcggaggtc
ttcggggacatcatgattgactacacctatgtggagtgcacctcagccgtgatgcaggcg
cttaagtatttccacaagcgtttcccggagcacagggcagcggagatccgggagaccctc
acgcagggcttagagttctgtcggcggcagcagagggccgatggctcctgggaaggctcc
tggggagtttgcttcacctacggcacctggtttggcctggaggccttcgcctgtatgggg
cagacctaccgagatgggactgcctgtgcagaggtctcccgggcctgtgacttcctgctg
tcccggcagatggcagacggaggctggggggaggactttgagtcctgcgaggagcggcgt
tatttgcagagtgcccagtcccagatccataacacatgctgggccatgatggggctgatg
gccgttcggcatcctgacatcgaggcccaggagagaggagtccggtgtctacttgagaaa
cagctccccaatggcgactggccgcaggaaaacattgctggggtcttcaacaagtcctgt
gccatctcctacacgagctacaggaacatcttccccatctgggccctcggccgcttctcc
cagctgtaccctgagagagcccttgctggccacccctga

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (15)   
   UniProt (2)   
   RefSeq(pep) (4)   
   IPI (9)   
DNA sequence (12)   
   RefSeq(nuc) (4)   
   GenBank (4)   
   EMBL (4)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (3)   
   PROSITE (1)   
All databases (51)

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