KEGG H.sapiens: 4048

Homo sapiens (human): 4048

Entry

4048 CDS H.sapiens

Gene name LTA4H

Definition leukotriene A4 hydrolase (EC:3.3.2.6)

Orthology K01254 leukotriene-A4 hydrolase [EC:3.3.2.6]

Pathway hsa00590 Arachidonic acid metabolism
hsa01100 Metabolic pathways

Class Metabolism; Lipid Metabolism; Arachidonic acid metabolism
[PATH:hsa00590]
Metabolism; Enzyme Families; Peptidases

SSDB

Motif Pfam: Peptidase_M1 Leuk-A4-hydro_C Peptidase_M48 Peptidase_M61
PROSITE: ZINC_PROTEASE

Other DBs NCBI-GI: 4505029
NCBI-GeneID: 4048
OMIM: 151570
HGNC: 6710
HPRD: 01056
Ensembl: ENSG00000111144
UniProt: P09960

Structure

PDB: 3B7S 3FUN 3FH5 3FH8 3FTV 3FUH 3FU0 3CHO
     3B7R 3FTW 2R59 3FUJ 3FTU 3B7U 3FUK 1HS6
     3FTX 3FTZ 3FU3 3FU6 3FH7 3CHQ 3CHP 3FUM
     3FTY 3FHE 3FUD 3FUI 3CHR 3FU5 3B7T 1SQM
     3FTS 3FUE 3FUL 3CHS 3FUF 2VJ8 1H19 1GW6

Position 12q22

AA seq 611 aa
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD

NT seq 1836 nt +upstreamnt +downstreamnt
atgcccgagatagtggatacctgttcgttggcctctccggcttccgtctgccggaccaag
cacctgcacctgcgctgcagcgtcgactttactcgccggacgctgaccgggactgctgct
ctcacggtccagtctcaggaggacaatctgcgcagcctggttttggatacaaaggacctt
acaatagaaaaagtagtgatcaatggacaagaagtcaaatatgctcttggagaaagacaa
agttacaagggatcgccaatggaaatctctcttcctatcgctttgagcaaaaatcaagaa
attgttatagaaatttcttttgagacctctccaaaatcttctgctctccagtggctcact
cctgaacagacttctgggaaggaacacccatatctctttagtcagtgccaggccatccac
tgcagagcaatccttccttgtcaggacactccttctgtgaaattaacctatactgcagag
gtgtctgtccctaaagaactggtggcacttatgagtgctattcgtgatggagaaacacct
gacccagaagacccaagcaggaaaatatacaaattcatccaaaaagttccaataccctgc
tacctgattgctttagttgttggagctttagaaagcaggcaaattggcccaagaactttg
gtgtggtctgagaaagagcaggtggaaaagtctgcttatgagttttctgagactgaatct
atgcttaaaatagcagaagatctgggaggaccgtatgtatggggacagtatgacctattg
gtcctgccaccatccttcccttatggtggcatggagaatccttgccttacttttgtaact
cctactctactggcaggcgacaagtcactctccaatgtcattgcacatgaaatatctcat
agctggacagggaatctagtgaccaacaaaacttgggatcacttttggttaaatgaggga
catactgtgtacttggaacgccacatttgcggacgattgtttggtgaaaagttcagacat
tttaatgctctgggaggatggggagaactacagaattcggtaaagacatttggggagaca
catcctttcaccaaacttgtggttgatctgacagatatagaccctgatgtagcttattct
tcagttccctatgagaagggctttgctttacttttttaccttgaacaactgcttggagga
ccagagattttcctaggattcttaaaagcttatgttgagaagttttcctataagagcata
actactgatgactggaaggatttcctgtattcctattttaaagataaggttgatgttctc
aatcaagttgattggaatgcctggctctactctcctggactgcctcccataaagcccaat
tatgatatgactctgacaaatgcttgtattgccttaagtcaaagatggattactgccaaa
gaagatgatttaaattcattcaatgccacagacctgaaggatctctcttctcatcaattg
aatgagtttttagcacagacgctccagagggcacctcttccattggggcacataaagcga
atgcaagaggtgtacaacttcaatgccattaacaattctgaaatacgattcagatggctg
cggctctgcattcaatccaagtgggaggacgcaattcctttggcgctaaagatggcaact
gaacaaggaagaatgaagtttacccggcccttattcaaggatcttgctgcctttgacaaa
tcccatgatcaagctgtccgaacctaccaagagcacaaagcaagcatgcatcccgtgact
gcaatgctggtggggaaagacttaaaagtggattaa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (13)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (11)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
3D Structure (40)   
   PDB (40)   
Protein domain (5)   
   Pfam (4)   
   PROSITE (1)   
All databases (82)

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