KEGG H.sapiens: 412

Homo sapiens (human): 412

Entry

412 CDS H.sapiens

Gene name STS

Definition steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2)

Orthology K01131 steryl-sulfatase [EC:3.1.6.2]

Pathway hsa00140 Steroid hormone biosynthesis

Disease H00134 X-linked ichthyosis (XLI)

Class Metabolism; Lipid Metabolism; Steroid hormone biosynthesis
[PATH:hsa00140]

SSDB

Motif Pfam: Sulfatase Phosphodiest
PROSITE: SULFATASE_1 SULFATASE_2

Other DBs NCBI-GI: 53831991
NCBI-GeneID: 412
OMIM: 300747
HGNC: 11425
HPRD: 02389
Ensembl: ENSG00000101846
UniProt: P08842

Structure

PDB: 1P49

Position Xp22.32

AA seq 583 aa
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

NT seq 1752 nt +upstreamnt +downstreamnt
atgcctttaaggaagatgaagatccctttcctcctactgttctttctgtgggaagccgag
agccacgcagcatcaaggccgaacatcatcctggtgatggctgacgacctcggcattgga
gatcctgggtgctatgggaacaaaactatcaggactcccaatatcgaccggttggccagt
gggggagtgaaactcactcagcacctggcagcatcaccgctgtgcacaccaagcagggca
gccttcatgactggccggtaccctgtccgatcaggaatggcatcttggtcccgcactgga
gttttcctcttcacagcctcttcgggaggacttcccaccgatgagattacctttgctaag
cttctgaaggatcaaggttattcaacagcactgatagggaaatggcaccttgggatgagc
tgtcacagcaagactgacttctgtcaccaccctttacatcacggcttcaattatttctat
gggatctctttgaccaatctgagagactgcaagcccggagagggcagtgtcttcaccacg
ggcttcaagaggctggtcttcctccccctgcagatcgtcggggtcaccctccttaccctt
gctgcactcaattgtctggggctactccacgtgcctctaggcgtttttttcagccttctc
ttcctagcagccctaatcctgacccttttcttgggcttccttcattacttccggcccctg
aactgcttcatgatgaggaactacgagatcattcagcagcccatgtcctatgacaatctc
acccagaggctaacggtggaggcggcccagttcatacagcggaacactgagactccgttc
ctgcttgtcttgtcctacctccacgtgcacacagccctgttctccagcaaagactttgct
ggcaaaagtcaacacggagtctacggggatgctgttgaggaaatggactggagtgtgggg
cagatcttgaaccttctggatgagctgagattggctaatgataccctcatctacttcaca
tcggaccagggagcacatgtagaagaagtgtcttccaaaggagaaattcatggcggaagt
aatgggatctataaaggaggaaaagcaaacaactgggaaggaggtatccgggttccaggc
atccttcgttggcccagggtgatacaggctggccagaagattgatgagcccactagcaac
atggacatatttcctacagtagccaagctggctggagctcccttgcctgaggacaggatc
attgatggacgtgatctgatgcccctgcttgaaggaaaaagccaacgctccgatcatgag
tttctcttccattactgcaacgcctacttaaatgctgtgcgctggcaccctcagaacagc
acatccatctggaaggcctttttcttcacccccaacttcaaccccgtgggttccaacgga
tgctttgccacacacgtgtgcttctgtttcgggagttatgtcacccatcacgacccacct
ttactctttgatatttccaaagatcccagagagagaaacccactaactccagcatccgag
ccccggttttatgaaatcctcaaagtcatgcaggaagctgcggacagacacacccagacc
ctgccagaggtgcccgatcagttttcatggaacaactttctttggaagccctggcttcag
ctgtgctgtccttccaccggcctgtcttgccagtgtgatagagaaaaacaggataagaga
ctgagccgctag

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (3)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (2)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (2)   
   PROSITE (2)   
All databases (38)

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