KEGG H.sapiens: 4143

Homo sapiens (human): 4143

Entry

4143 CDS H.sapiens

Gene name MAT1A

Definition methionine adenosyltransferase I, alpha (EC:2.5.1.6)

Orthology K00789 S-adenosylmethionine synthetase [EC:2.5.1.6]

Pathway hsa00270 Cysteine and methionine metabolism
hsa00450 Selenoamino acid metabolism
hsa01100 Metabolic pathways

Disease H00184 Hypermethioninemia

Class Metabolism; Amino Acid Metabolism; Cysteine and methionine
metabolism [PATH:hsa00270]
Metabolism; Metabolism of Other Amino Acids; Selenoamino acid
metabolism [PATH:hsa00450]

SSDB

Motif Pfam: S-AdoMet_synt_C S-AdoMet_synt_M S-AdoMet_synt_N
PROSITE: ADOMET_SYNTHETASE_1 ADOMET_SYNTHETASE_2

Other DBs NCBI-GI: 4557737
NCBI-GeneID: 4143
OMIM: 610550
HGNC: 6903
HPRD: 02013
Ensembl: ENSG00000151224
UniProt: Q00266

Structure

PDB: 2OBV

Position 10q22

AA seq 395 aa
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVC
KTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQC
VHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDS
KTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDT
VYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVI
VRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF

NT seq 1188 nt +upstreamnt +downstreamnt
atgaatggaccggtggatggcttgtgtgaccactctctaagtgaaggagtcttcatgttc
acatcggagtctgtgggagagggacacccggataagatctgtgaccagatcagtgatgca
gtgctggatgcccatctcaagcaagaccccaatgccaaggtggcctgtgagacagtgtgc
aagaccggcatggtgctgctgtgtggtgagatcacctcaatggccatggtggactaccag
cgggtggtgagggacaccatcaagcacatcggctacgatgactcagccaagggctttgac
ttcaagacttgcaacgtgctggtggctttggagcagcaatccccagatattgcccagtgc
gtccatctggacagaaatgaggaggatgtgggggcaggagatcagggtttgatgttcggc
tatgctaccgacgagacagaggagtgcatgcccctcaccatcatccttgctcacaagctc
aacgcccggatggcagacctcaggcgctccggcctcctcccctggctgcggcctgactct
aagactcaggtgacagttcagtacatgcaggacaatggcgcagtcatccctgtgcgcatc
cacaccatcgtcatctctgtgcagcacaacgaagacatcacgctggaggagatgcgcagg
gccctgaaggagcaagtcatcagggccgtggtgccggccaagtacctggacgaagacacc
gtctaccacctgcagcccagtgggcggtttgtcatcggaggtccccagggggatgcgggt
gtcactggccgtaagattattgtggacacctatggcggctggggggctcatggtggtggg
gccttctctgggaaggactacaccaaggtagaccgctcagctgcatatgctgcccgctgg
gtggccaagtctctggtgaaagcagggctctgccggagagtgcttgtccaggtttcctat
gccattggtgtggccgagccgctgtccatttccatcttcacctacggaacctctcagaag
acagagcgagagctgctggatgtggtgcataagaacttcgacctccggccgggcgtcatt
gtcagggatttggacttgaagaagcccatctaccagaagacagcatgctacggccatttc
ggaagaagcgagttcccatgggaggttcccaggaagcttgtattttag

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (2)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (3)   
   PROSITE (2)   
All databases (33)

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