KEGG H.sapiens: 51520

rso:RS02649 : No such data.

Homo sapiens (human): 51520

Entry

51520 CDS H.sapiens

Gene name LARS

Definition leucyl-tRNA synthetase (EC:6.1.1.4)

Orthology K01869 leucyl-tRNA synthetase [EC:6.1.1.4]

Pathway hsa00290 Valine, leucine and isoleucine biosynthesis
hsa00970 Aminoacyl-tRNA biosynthesis

Class Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine
biosynthesis [PATH:hsa00290]
Genetic Information Processing; Translation; Aminoacyl-tRNA
biosynthesis [PATH:hsa00970]

SSDB

Motif Pfam: tRNA-synt_1 tRNA-synt_1g Anticodon_1 tRNA-synt_1e
PROSITE: AA_TRNA_LIGASE_I

Other DBs NCBI-GI: 108773810
NCBI-GeneID: 51520
OMIM: 151350
HGNC: 6512
HPRD: 01042
Ensembl: ENSG00000133706
UniProt: A7E266 Q9P2J5

Structure

PDB: 2WFD

Position 5q32

AA seq 1176 aa
MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH

NT seq 3531 nt +upstreamnt +downstreamnt
atggcggaaagaaaaggaacagccaaagtggactttttgaagaagattgagaaagaaatc
caacagaaatgggatactgagagagtgtttgaggtcaatgcatctaatttagagaaacag
accagcaagggcaagtattttgtaaccttcccatatccatatatgaatggacgccttcat
ttgggacacacgttttctttatccaaatgtgagtttgctgtagggtaccagcgattgaaa
ggaaaatgttgtctgtttccctttggcctgcactgtactggaatgcctattaaggcatgt
gctgataagttgaaaagagaaatagagctgtatggttgcccccctgattttccagatgaa
gaagaggaagaggaagaaaccagtgttaaaacagaagatataataattaaggataaagct
aaaggaaaaaagagtaaagctgctgctaaagctggatcttctaaataccagtggggcatt
atgaaatcccttggcctgtctgatgaagagatagtaaaattttctgaagcagaacattgg
cttgattatttcccgccactggctattcaggatttaaaaagaatgggtttgaaggtagac
tggcgtcgttccttcatcaccactgatgttaatccttactatgattcatttgtcagatgg
caatttttaacattaagagaaagaaacaaaattaaatttgggaagcggtatacaatttac
tctccgaaagatggacagccttgcatggatcatgatagacaaactggagagggtgttgga
cctcaggaatatactttactcaaattgaaggtgcttgagccatacccatctaaattaagt
ggcctgaaaggtaaaaatattttcttggtggctgctactctcagacctgagaccatgttt
gggcagacaaattgttgggttcgtcctgatatgaagtacattggatttgagacggtgaat
ggtgatatattcatctgtacccaaaaagcagccaggaatatgtcataccagggctttacc
aaagacaatggcgtggtgcctgttgttaaggaattaatgggggaggaaattcttggtgca
tcactttctgcacctttaacatcatacaaggtgatctatgttctcccaatgctaactatt
aaggaggataaaggcactggtgtggttacaagtgttccttccgactcccctgatgatatt
gctgccctcagagacttgaagaaaaagcaagccttacgagcaaaatatggaattagagat
gacatggtcttgccatttgagccggtgccagtcattgaaatcccaggttttggaaatctt
tctgctgtaaccatttgtgatgagttgaaaattcagagccagaatgaccgggaaaaactt
gcagaagcaaaggagaagatatatctaaaaggattttatgagggtatcatgttggtggat
ggatttaaaggacagaaggttcaagatgtaaagaagactattcagaaaaagatgattgac
gctggagatgcacttatttacatggaaccagagaaacaagtgatgtccaggtcgtcagat
gaatgtgttgtggctctgtgtgaccagtggtacttggattatggagaagagaattggaag
aaacagacatctcagtgcttgaagaacctggaaacattctgtgaggagaccaggaggaat
tttgaagccaccttaggttggctacaagaacatgcttgctcaagaacttatggtctaggc
actcacctgccttgggatgagcagtggctgattgaatcactttctgactccactatttac
atggcattttacacagttgcacacctattgcaggggggtaacttgcatggacaggcagag
tctccgctgggcattagaccgcaacagatgaccaaggaagtttgggattatgttttcttc
aaggaggctccatttcctaagactcagattgcaaaggaaaaattagatcagttaaagcag
gagtttgaattctggtatcctgttgatcttcgcgtctctggcaaggatcttgttccaaat
catctttcatattacctttataatcatgtggctatgtggccggaacaaagtgacaaatgg
cctacagctgtgagagcaaatggacatctcctcctgaactctgagaagatgtcaaaatcc
acaggcaacttcctcactttgacccaagctattgacaaattttcagcagatggaatgcgt
ttggctctggctgatgctggtgacactgtagaagatgccaactttgtggaagccatggca
gatgcaggtattctccgtctgtacacctgggtagagtgggtgaaagaaatggttgccaac
tgggacagcctaagaagtggtcctgccagcactttcaatgatagagtttttgccagtgaa
ttgaatgcaggaattataaaaacagatcaaaactatgaaaagatgatgtttaaagaagct
ttgaaaacagggttttttgagtttcaggccgcaaaagataagtaccgtgaattggctgtg
gaagggatgcacagagaacttgtgttccggtttattgaagttcagacacttctcctcgct
ccattctgtccacatttgtgtgagcacatctggacactcctgggaaagcctgactcaatt
atgaatgcttcatggcctgtggcaggtcctgttaatgaagttttaatacactcctcacag
tatcttatggaagtaacacatgaccttagactacgactcaagaactatatgatgccagct
aaagggaagaagactgacaaacaacccctgcagaagccctcacattgcaccatctatgtg
gcaaagaactatccaccttggcaacataccaccctgtctgttctacgtaaacactttgag
gccaataacggaaaactgcctgacaacaaagtcattgctagtgaactaggcagtatgcca
gaactgaagaaatacatgaagaaagtcatgccatttgttgccatgattaaggaaaatctg
gagaagatggggcctcgtattctggatttgcaattagaatttgatgaaaaggctgtgctt
atggagaatatagtctatctgactaattcgcttgagctagaacacatagaagtcaagttt
gcctccgaagcagaagataaaatcagggaagactgctgtcctgggaaaccacttaatgtt
tttagaatagaacctggtgtgtccgtttctctggtgaatccccagccatccaatggccac
ttctcaaccaaaattgaaatcaggcaaggagataactgtgattccataatcaggcgttta
atgaaaatgaatcgaggaattaaagacctttccaaagtgaaactgatgagatttgatgat
ccactgttggggcctcgacgagttcctgtcctgggaaaggagtacaccgagaagaccccc
atttctgagcatgctgttttcaatgtggacctcatgagcaagaaaattcatctgactgag
aatgggataagggtggatattggcgatacaataatctatctggttcattaa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (7)   
   UniProt (2)   
   RefSeq(pep) (1)   
   IPI (4)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (4)   
   PROSITE (1)   
All databases (35)

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