KEGG   Homo sapiens (human): 5160Help
Entry
5160              CDS       H.sapiens                              
Gene name PDHA1
Definition pyruvate dehydrogenase (lipoamide) alpha 1 (EC:1.2.4.1)
Orthology K00161  pyruvate dehydrogenase E1 component subunit alpha
        [EC:1.2.4.1]
Pathway hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00290  Valine, leucine and isoleucine biosynthesis
hsa00620  Pyruvate metabolism
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
Disease H00072  Pyruvate dehydrogenase complex deficiency
Class Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis
[PATH:hsa00010]
Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle)
[PATH:hsa00020]
Metabolism; Carbohydrate Metabolism; Pyruvate metabolism
[PATH:hsa00620]
Metabolism; Carbohydrate Metabolism; Butanoate metabolism
[PATH:hsa00650]
Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine
biosynthesis [PATH:hsa00290]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: E1_dh TPP_enzyme_C
Motif
Other DBs NCBI-GI: 4505685
NCBI-GeneID: 5160
OMIM: 300502
HGNC: 8806
HPRD: 02420
Ensembl: ENSG00000131828
UniProt: P08559
Structure
PDB: 2OZL 1NI4 3EXE 3EXI 3EXH 3EXF 3EXG
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Jmol
Position Xp22.2-p22.1
AA seq 390 aa AA seqDB search
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq 1173 nt NT seq  +upstreamnt  +downstreamnt
atgaggaagatgctcgccgccgtctcccgcgtgctgtctggcgcttctcagaagccggca
agcagagtgctggtagcatcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgtgaccttcaccggctggaagaaggccctcctgtcacaacagtgctcaccagggaggat
gggctcaaatactacaggatgatgcagactgtacgccgaatggagttgaaagcagatcag
ctgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgc
tgtgtgggcctggaggccggcatcaaccccacagaccatctcatcacagcctaccgggct
cacggctttactttcacccggggcctttccgtccgagaaattctcgcagagcttacagga
cgaaaaggaggttgtgctaaagggaaaggaggatcgatgcacatgtatgccaagaacttc
tacgggggcaatggcatcgtgggagcgcaggtgcccctgggcgctgggattgctctagcc
tgtaagtataatggaaaagatgaggtctgcctgactttatatggcgatggtgctgctaac
cagggccagatattcgaagcttacaacatggcagctttgtggaaattaccttgtattttc
atctgtgagaataatcgctatggaatgggaacgtctgttgagagagcggcagccagcact
gattactacaagagaggcgatttcattcctgggctgagagtggatggaatggatatcctg
tgcgtccgagaggcaacaaggtttgctgctgcctattgtagatctgggaaggggcccatc
ctgatggagctgcagacttaccgttaccacggacacagtatgagtgaccctggagtcagt
taccgtacacgagaagaaattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggacaggatggtgaacagcaatcttgccagtgtggaagaactaaaggaaattgatgtg
gaagtgaggaaggagattgaggatgctgcccagtttgccacggccgatcctgagccacct
ttggaagagctgggctaccacatctactccagcgacccaccttttgaagttcgtggtgcc
aatcagtggatcaagtttaagtcagtcagttaa
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