KEGG H.sapiens: 5286

Homo sapiens (human): 5286

Entry

5286 CDS H.sapiens

Gene name PIK3C2A

Definition phosphoinositide-3-kinase, class 2, alpha polypeptide (EC:2.7.1.154)

Orthology K00923 phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]

Pathway hsa00562 Inositol phosphate metabolism
hsa01100 Metabolic pathways
hsa04070 Phosphatidylinositol signaling system

Class Metabolism; Carbohydrate Metabolism; Inositol phosphate metabolism
[PATH:hsa00562]
Environmental Information Processing; Signal Transduction;
Phosphatidylinositol signaling system [PATH:hsa04070]

SSDB

Motif Pfam: PI3_PI4_kinase PI3Ka PI3K_C2 PI3K_rbd PX C2
PROSITE: PI3_4_KINASE_1 PI3_4_KINASE_2 C2 PX PI3_4_KINASE_3

Other DBs NCBI-GI: 157671929
NCBI-GeneID: 5286
OMIM: 603601
HGNC: 8971
HPRD: 04672
Ensembl: ENSG00000011405
UniProt: O00443

Structure

PDB: 2AR5 2RED 2REA 2IWL

Position 11p15.5-p14

AA seq 1686 aa
MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSS
TRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVT
PILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFP
STEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNG
KARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLA
KDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNG
TSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGE
NASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEV
LQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKP
CKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESV
KKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHA
NSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDL
FKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNK
QRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDF
PSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRY
YCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAV
TWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHD
VQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSME
RVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVG
EDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEY
GVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRS
TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY
NLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLG
SIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDK
HYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVA
AKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIG
GAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRN
PTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQL
TAATYL

NT seq 5061 nt +upstreamnt +downstreamnt
atggctcagatatctagcaacagcggatttaaagaatgtccatcttcacatccggaacca
acaagagcaaaagatgtggacaaagaagaagcattacagatggaagcagaggctttagca
aaactgcaaaaggatagacaagtgactgacaatcagagaggctttgagttgtcaagcagc
accagaaaaaaagcacaggtttataacaagcaggattatgatctcatggtgtttcctgaa
tcagattcccaaaaaagagcattagatattgatgtagaaaagctcacccaagctgaactt
gagaaactattgctggatgacagtttcgagactaaaaaaacacctgtattaccagttact
cctattctgagcccttccttttcagcacagctctattttagacctactattcagagagga
cagtggccacctggattacctgggccttccacttatgctttaccttctatttatccttct
acttacagtaaacaggctgcattccaaaatggcttcaatccaagaatgcccacttttcca
tctacagaacctatatatttaagtcttccgggacaatctccatatttctcatatcctttg
acacctgccacaccctttcatccacaaggaagcttacctatctatcgtccagtagtcagt
actgacatggcaaaactatttgacaaaatagctagtacatcagaatttttaaaaaatggg
aaagcaaggactgatttggagataacagattcaaaagtcagcaatctacaggtatctcca
aagtctgaggatatcagtaaatttgactggttagacttggatcctctaagtaagcctaag
gtggataatgtggaggtattagaccatgaggaagagaaaaatgtttcaagtttgctagca
aaggatccttgggatgctgttcttcttgaagagagatcgacagcaaattgtcatcttgaa
agaaaggtgaatggaaaatccctttctgtggcaactgttacaagaagccagtctttaaat
attcgaacaactcagcttgcaaaagcccagggccatatatctcagaaagacccaaatggg
accagtagtttgccaactggaagttctcttcttcaagaagttgaagtacagaatgaggag
atggcagctttttgtcgatccattacaaaattgaagaccaaatttccatataccaatcac
cgcacaaacccaggctatttgttaagtccagtcacagcacaaagaaacatatgcggagaa
aatgctagtgtgaaggtctccattgacattgaaggatttcagctaccagttacttttacg
tgtgatgtgagttctactgtagaaatcattataatgcaagccctttgctgggtacatgat
gacttgaatcaagtagatgttggcagctatgttctaaaagtttgtggtcaagaggaagtg
ctgcagaataatcattgccttggaagtcatgagcatattcaaaactgtcgaaaatgggac
acagaaattagactacaactcttgaccttcagtgcaatgtgtcaaaatctggcccgaaca
gcagaagatgatgaaacacccgtggatttaaacaaacacctgtatcaaatagaaaaacct
tgcaaagaagccatgacgagacaccctgttgaagaactcttagattcttatcacaaccaa
gtagaactggctcttcaaattgaaaaccaacaccgagcagtagatcaagtaattaaagct
gtaagaaaaatctgtagtgctttagatggtgtcgagactcttgccattacagaatcagta
aagaagctaaagagagcagttaatcttccaaggagtaaaactgctgatgtgacttctttg
tttggaggagaagacactagcaggagttcaactaggggctcacttaatcctgaaaatcct
gttcaagtaagcataaaccaattaactgcagcaatttatgatcttctcagactccatgca
aattctggtaggagtcctacagactgtgcccaaagtagcaagagtgtcaaggaagcatgg
actacaacagagcagctccagtttactatttttgctgctcatggaatttcaagtaattgg
gtatcaaattatgaaaaatactacttgatatgttcactgtctcacaatggaaaggatctt
tttaaacctattcaatcaaagaaggttggcacttacaagaatttcttctatcttattaaa
tgggatgaactaatcatttttcctatccagatatcacaattgccattagaatcagttctt
caccttactctttttggaattttaaatcagagcagtggaagttcccctgattctaataag
cagagaaagggaccagaagctttgggcaaagtttctttacctctttttgactttaaacgg
tttttaacatgtggaactaaacttctatatctttggacttcatcacatacaaattctgtt
cctggaacagttaccaaaaaaggatatgtcatggaaagaatagtgctacaggttgatttt
ccttctcctgcatttgatattatttatacaactcctcaagttgacagaagcattatacag
caacataacttagaaacactagagaatgatataaaagggaaacttcttgatattcttcat
aaagactcatcacttggactttctaaagaagataaagcttttttatgggagaaacgttat
tattgcttcaaacacccaaattgtcttcctaaaatattagcaagcgccccaaactggaaa
tgggttaatcttgccaaaacttactcattgcttcaccagtggcctgcattgtacccacta
attgcattggaacttcttgattcaaaatttgctgatcaggaagtaagatccctagctgtg
acctggattgaggccattagtgatgatgagctaacagatcttcttccacagtttgtacaa
gctttgaaatatgaaatttacttgaatagttcattagtgcaattccttttgtccagggca
ttgggaaatatccagatagcacacaatttatattggcttctcaaagatgccctgcatgat
gtacagtttagtacccgatacgaacatgttttgggtgctctcctgtcagtaggaggaaaa
cgacttagagaagaacttctaaaacagacgaaacttgtacagcttttaggaggagtagca
gaaaaagtaaggcaggctagtggatcagccagacaggttgttctccaaagaagtatggaa
cgagtacagtccttttttcagaaaaataaatgccgtctccctctcaagccaagtctagtg
gcaaaagaattaaatattaagtcgtgttccttcttcagttctaatgctgtccccctaaaa
gtcacaatggtgaatgctgaccctatgggagaagaaattaatgtcatgtttaaggttggt
gaagatcttcggcaagatatgttagctttacagatgataaagattatggataagatctgg
cttaaagaaggactagatctgaggatggtaattttcaaatgtctctcaactggcagagat
cgaggcatggtggagctggttcctgcttccgataccctcaggaaaatccaagtggaatat
ggtgtgacaggatcctttaaagataaaccacttgcagagtggctaaggaaatacaatccc
tctgaagaagaatatgaaaaggcttcagagaactttatctattcctgtgctggatgctgt
gtagccacctatgttttaggcatctgtgatcgacacaatgacaatataatgcttcgaagc
acgggacacatgtttcacattgactttggaaagtttttgggacatgcacagatgtttggc
agcttcaaaagggatcgggctccttttgtgctgacctctgatatggcatatgtcattaat
gggggtgaaaagcccaccattcgttttcagttgtttgtggacctctgctgtcaggcctac
aacttgataagaaagcagacaaacctttttcttaacctcctttcactgatgattccttca
gggttaccagaacttacaagtattcaagatttgaaatacgttagagatgcacttcaaccc
caaactacagacgcagaagctacaattttctttactaggcttattgaatcaagtttggga
agcattgccacaaagtttaacttcttcattcacaaccttgctcagcttcgtttttctggt
cttccttctaatgatgagcccatcctttcattttcacctaaaacatactcctttagacaa
gatggtcgaatcaaggaagtctctgtttttacatatcataagaaatacaacccagataaa
cattatatttatgtagtccgaattttgagggaaggacagattgaaccatcatttgtcttc
cgaacatttgacgaatttcaggaacttcacaataagctcagtattatttttccactttgg
aagttaccaggctttcctaataggatggttctaggaagaacacacataaaagatgtagca
gccaaaaggaaaattgagttaaacagttacttacagagtttgatgaatgcttcaacggat
gtagcagagtgtgatcttgtttgtactttcttccaccctttacttcgtgatgagaaagct
gaagggatagctaggtctgcagatgcaggttccttcagtcctactccaggccaaatagga
ggagctgtgaaattatccatctcttaccgaaatggtactcttttcatcatggtgatgcat
atcaaagatcttgttactgaagatggagctgacccaaatccatatgtcaaaacataccta
cttccagataaccacaaaacatccaaacgtaaaaccaaaatttcacgaaaaacgaggaat
ccgacattcaatgaaatgcttgtatacagtggatatagcaaagaaaccctaagacagcga
gaacttcaactaagtgtactcagtgcagaatctctgcgggagaattttttcttgggtgga
gtaaccctgcctttgaaagatttcaacttgagcaaagagacggttaaatggtatcagctg
actgcggcaacatacttgtaa

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (1)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
3D Structure (4)   
   PDB (4)   
Protein domain (11)   
   Pfam (6)   
   PROSITE (5)   
All databases (45)

DBGET integrated database retrieval system