KEGG   Homo sapiens (human): 5315Help
Entry
5315              CDS       H.sapiens                              
Gene name PKM2
Definition pyruvate kinase, muscle (EC:2.7.1.40)
Orthology K00873  pyruvate kinase [EC:2.7.1.40]
Pathway hsa00010  Glycolysis / Gluconeogenesis
hsa00230  Purine metabolism
hsa00620  Pyruvate metabolism
hsa01100  Metabolic pathways
hsa04930  Type II diabetes mellitus
Class Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis
[PATH:hsa00010]
Metabolism; Carbohydrate Metabolism; Pyruvate metabolism
[PATH:hsa00620]
Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:hsa00230]
Human Diseases; Metabolic Diseases; Type II diabetes mellitus
[PATH:hsa04930]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: PK PK_C HpcH_HpaI IMPDH
PROSITE: PYRUVATE_KINASE PUA
Motif
Other DBs NCBI-GI: 33286418
NCBI-GeneID: 5315
OMIM: 179050
HGNC: 9021
HPRD: 01529
Ensembl: ENSG00000067225
UniProt: P14618
Structure
PDB: 3GR4 3GQY 3H6O 3G2G 3BJF 1ZJH 3BJT 1T5A
     
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Jmol
Position 15q22
AA seq 531 aa AA seqDB search
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
NT seq 1596 nt NT seq  +upstreamnt  +downstreamnt
atgtcgaagccccatagtgaagccgggactgccttcattcagacccagcagctgcacgca
gccatggctgacacattcctggagcacatgtgccgcctggacattgattcaccacccatc
acagcccggaacactggcatcatctgtaccattggcccagcttcccgatcagtggagacg
ttgaaggagatgattaagtctggaatgaatgtggctcgtctgaacttctctcatggaact
catgagtaccatgcggagaccatcaagaatgtgcgcacagccacggaaagctttgcttct
gaccccatcctctaccggcccgttgctgtggctctagacactaaaggacctgagatccga
actgggctcatcaagggcagcggcactgcagaggtggagctgaagaagggagccactctc
aaaatcacgctggataacgcctacatggaaaagtgtgacgagaacatcctgtggctggac
tacaagaacatctgcaaggtggtggaagtgggcagcaagatctacgtggatgatgggctt
atttctctccaggtgaagcagaaaggtgccgacttcctggtgacggaggtggaaaatggt
ggctccttgggcagcaagaagggtgtgaaccttcctggggctgctgtggacttgcctgct
gtgtcggagaaggacatccaggatctgaagtttggggtcgagcaggatgttgatatggtg
tttgcgtcattcatccgcaaggcatctgatgtccatgaagttaggaaggtcctgggagag
aagggaaagaacatcaagattatcagcaaaatcgagaatcatgagggggttcggaggttt
gatgaaatcctggaggccagtgatgggatcatggtggctcgtggtgatctaggcattgag
attcctgcagagaaggtcttccttgctcagaagatgatgattggacggtgcaaccgagct
gggaagcctgtcatctgtgctactcagatgctggagagcatgatcaagaagccccgcccc
actcgggctgaaggcagtgatgtggccaatgcagtcctggatggagccgactgcatcatg
ctgtctggagaaacagccaaaggggactatcctctggaggctgtgcgcatgcagcacctg
attgcccgtgaggcagaggctgccatctaccacttgcaattatttgaggaactccgccgc
ctggcgcccattaccagcgaccccacagaagccaccgccgtgggtgccgtggaggcctcc
ttcaagtgctgcagtggggccataatcgtcctcaccaagtctggcaggtctgctcaccag
gtggccagataccgcccacgtgcccccatcattgctgtgacccggaatccccagacagct
cgtcaggcccacctgtaccgtggcatcttccctgtgctgtgcaaggacccagtccaggag
gcctgggctgaggacgtggacctccgggtgaactttgccatgaatgttggcaaggcccga
ggcttcttcaagaagggagatgtggtcattgtgctgaccggatggcgccctggctccggc
ttcaccaacaccatgcgtgttgttcctgtgccgtga
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