KEGG   Homo sapiens (human): 5604Help
Entry
5604              CDS       T01001                                 

Gene name
MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Definition
(RefSeq) mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04114  Oocyte meiosis
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04218  Cellular senescence
hsa04270  Vascular smooth muscle contraction
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04620  Toll-like receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing's syndrome
hsa05020  Prion diseases
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  Mutation-activated BRAF to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N10008  Kinase inhibitor to MEK downstream of BRAF mutation
Disease
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
Drug target
Binimetinib: D10604
Cobimetinib (DG01825): D10405 D10615
Pimasertib (DG01410): D10426 D10486
Selumetinib (DG01414): D09666 D10024
Trametinib (DG00723): D10175 D10176
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5604 (MAP2K1)
   04015 Rap1 signaling pathway
    5604 (MAP2K1)
   04010 MAPK signaling pathway
    5604 (MAP2K1)
   04012 ErbB signaling pathway
    5604 (MAP2K1)
   04370 VEGF signaling pathway
    5604 (MAP2K1)
   04371 Apelin signaling pathway
    5604 (MAP2K1)
   04668 TNF signaling pathway
    5604 (MAP2K1)
   04066 HIF-1 signaling pathway
    5604 (MAP2K1)
   04068 FoxO signaling pathway
    5604 (MAP2K1)
   04072 Phospholipase D signaling pathway
    5604 (MAP2K1)
   04071 Sphingolipid signaling pathway
    5604 (MAP2K1)
   04024 cAMP signaling pathway
    5604 (MAP2K1)
   04022 cGMP - PKG signaling pathway
    5604 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    5604 (MAP2K1)
   04150 mTOR signaling pathway
    5604 (MAP2K1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    5604 (MAP2K1)
  Cell growth and death
   04114 Oocyte meiosis
    5604 (MAP2K1)
   04210 Apoptosis
    5604 (MAP2K1)
   04218 Cellular senescence
    5604 (MAP2K1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5604 (MAP2K1)
   04540 Gap junction
    5604 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5604 (MAP2K1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5604 (MAP2K1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    5604 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    5604 (MAP2K1)
   04660 T cell receptor signaling pathway
    5604 (MAP2K1)
   04662 B cell receptor signaling pathway
    5604 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    5604 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    5604 (MAP2K1)
   04062 Chemokine signaling pathway
    5604 (MAP2K1)
  Endocrine system
   04910 Insulin signaling pathway
    5604 (MAP2K1)
   04912 GnRH signaling pathway
    5604 (MAP2K1)
   04915 Estrogen signaling pathway
    5604 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    5604 (MAP2K1)
   04917 Prolactin signaling pathway
    5604 (MAP2K1)
   04921 Oxytocin signaling pathway
    5604 (MAP2K1)
   04926 Relaxin signaling pathway
    5604 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    5604 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    5604 (MAP2K1)
   04916 Melanogenesis
    5604 (MAP2K1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    5604 (MAP2K1)
  Nervous system
   04725 Cholinergic synapse
    5604 (MAP2K1)
   04726 Serotonergic synapse
    5604 (MAP2K1)
   04720 Long-term potentiation
    5604 (MAP2K1)
   04730 Long-term depression
    5604 (MAP2K1)
   04722 Neurotrophin signaling pathway
    5604 (MAP2K1)
  Development
   04380 Osteoclast differentiation
    5604 (MAP2K1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5604 (MAP2K1)
   05230 Central carbon metabolism in cancer
    5604 (MAP2K1)
   05231 Choline metabolism in cancer
    5604 (MAP2K1)
   05206 MicroRNAs in cancer
    5604 (MAP2K1)
   05205 Proteoglycans in cancer
    5604 (MAP2K1)
   05210 Colorectal cancer
    5604 (MAP2K1)
   05212 Pancreatic cancer
    5604 (MAP2K1)
   05225 Hepatocellular carcinoma
    5604 (MAP2K1)
   05226 Gastric cancer
    5604 (MAP2K1)
   05214 Glioma
    5604 (MAP2K1)
   05216 Thyroid cancer
    5604 (MAP2K1)
   05221 Acute myeloid leukemia
    5604 (MAP2K1)
   05220 Chronic myeloid leukemia
    5604 (MAP2K1)
   05218 Melanoma
    5604 (MAP2K1)
   05211 Renal cell carcinoma
    5604 (MAP2K1)
   05219 Bladder cancer
    5604 (MAP2K1)
   05215 Prostate cancer
    5604 (MAP2K1)
   05213 Endometrial cancer
    5604 (MAP2K1)
   05224 Breast cancer
    5604 (MAP2K1)
   05223 Non-small cell lung cancer
    5604 (MAP2K1)
  Neurodegenerative diseases
   05020 Prion diseases
    5604 (MAP2K1)
  Substance dependence
   05034 Alcoholism
    5604 (MAP2K1)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    5604 (MAP2K1)
  Infectious diseases
   05164 Influenza A
    5604 (MAP2K1)
   05161 Hepatitis B
    5604 (MAP2K1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    5604 (MAP2K1)
   05165 Human papillomavirus infection
    5604 (MAP2K1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5604 (MAP2K1)
   01522 Endocrine resistance
    5604 (MAP2K1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     5604 (MAP2K1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE7 family
   5604 (MAP2K1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Haspin_kinase Seadorna_VP7 Kinase-like DUF3216 NAD_binding_6
Motif
Other DBs
NCBI-GeneID: 5604
NCBI-ProteinID: NP_002746
OMIM: 176872
HGNC: 6840
Ensembl: ENSG00000169032
Vega: OTTHUMG00000133196
Pharos: Q02750(Tclin)
UniProt: Q02750 A4QPA9
Structure
PDB: 

Jmol
Position
15q22.31
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactgtctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggaa
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatac
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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