KEGG H.sapiens: 6240

Homo sapiens (human): 6240

Entry

6240 CDS H.sapiens

Gene name RRM1

Definition ribonucleotide reductase M1 (EC:1.17.4.1)

Orthology K10807 ribonucleoside-diphosphate reductase subunit M1
[EC:1.17.4.1]

Pathway hsa00230 Purine metabolism
hsa00240 Pyrimidine metabolism
hsa00480 Glutathione metabolism
hsa01100 Metabolic pathways

Class Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:hsa00230]
Metabolism; Nucleotide Metabolism; Pyrimidine metabolism
[PATH:hsa00240]
Metabolism; Metabolism of Other Amino Acids; Glutathione metabolism
[PATH:hsa00480]
Genetic Information Processing; Replication and Repair; DNA repair
and recombination proteins

SSDB

Motif Pfam: Ribonuc_red_lgC Ribonuc_red_lgN ATP-cone
PROSITE: RIBORED_LARGE ATP_CONE

Other DBs NCBI-GI: 4506749
NCBI-GeneID: 6240
OMIM: 180410
HGNC: 10451
HPRD: 01588
Ensembl: ENSG00000167325
UniProt: P23921

Structure

PDB: 2WGH

Position 11p15.5

AA seq 792 aa
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS

NT seq 2379 nt +upstreamnt +downstreamnt
atgcatgtgatcaagcgagatggccgccaagaacgagtcatgtttgacaaaattacatct
cgaatccagaagctttgttatggactcaatatggattttgttgatcctgctcagatcacc
atgaaagtaatccaaggcttgtacagtggggtcaccacagtggaactagatactttggct
gctgaaacagctgcaaccttgactactaagcaccctgactatgctatcctggcagccagg
atcgctgtctctaacttgcacaaagaaacaaagaaagtgttcagtgatgtgatggaagac
ctctataactacataaatccacataatggcaaacactctcccatggtggccaagtcaaca
ttggatattgttctggccaataaagatcgcctgaattctgctattatctatgaccgagat
ttctcttacaattacttcggctttaagacgctagagcggtcttatttgttgaagatcaat
ggaaaagtggctgaaagaccacaacatatgttgatgagagtatctgttgggatccacaaa
gaagacattgatgcagcaattgaaacatataatcttctttctgagaggtggtttactcat
gcttcgcccactctcttcaatgctggtaccaaccgcccacaactttctagctgttttctt
ctgagtatgaaagatgacagcattgaaggcatttatgacactctaaagcaatgtgcattg
atttctaagtctgctggaggaattggtgttgctgtgagttgtattcgggctactggcagc
tacattgctgggactaatggcaattccaatggccttgtaccgatgctgagagtatataac
aacacagctcgatatgtggatcaaggtgggaacaagcgtcctggggcatttgctatttac
ctggagccttggcatttagacatctttgaattccttgatttaaagaagaacacaggaaag
gaagagcagcgtgccagagatcttttctttgctctttggattccggatctcttcatgaaa
cgagtggagactaatcaggactggtctttgatgtgtccaaatgagtgtcctggtctggat
gaggtttggggagaggaatttgagaaactatatgcaagttatgagaaacaaggtcgtgtc
cgcaaagttgtaaaagctcagcagctttggtatgccatcattgagtctcagacggaaaca
ggcaccccgtatatgctctacaaagattcctgtaatcgaaagagcaaccagcagaacctg
ggaaccatcaaatgcagcaacctgtgcacagaaatagtggagtacaccagcaaagatgag
gttgctgtttgtaatttggcttccctggccctgaatatgtatgtcacatcagaacacaca
tacgactttaagaagttggctgaagtcactaaagtcgttgtccgaaacttgaataaaatt
attgatataaactactatcctgtaccagaggcatgcctatcaaataaacgccatcgcccc
attggaattggggtacaaggtctggcagatgcttttatcctgatgagatacccttttgag
agtgcagaagcccagttactgaataagcagatctttgaaactatttattatggtgctctg
gaagccagctgtgaccttgccaaggagcagggcccatacgaaacctatgagggctctcca
gttagcaaaggaattcttcagtatgatatgtggaatgttactcctacagacctatgggac
tggaaggttctcaaggagaagattgcaaagtatggtataagaaacagtttacttattgcc
ccgatgcctacagcttccactgctcagatcctggggaataatgagtccattgaaccttac
accagcaacatctatactcgcagagtcttgtcaggagaatttcagattgtaaatcctcac
ttattgaaagatcttaccgagcggggcctatggcatgaagagatgaaaaaccagattatt
gcatgcaatggctctattcagagcataccagaaattcctgatgacctgaagcaactttat
aaaactgtgtgggaaatctctcagaaaactgttctcaagatggcagctgagagaggtgct
ttcattgatcaaagccaatctttgaacatccacattgctgagcctaactatggcaaactc
actagtatgcacttctacggctggaagcagggtttgaagactgggatgtattatttaagg
acaagaccagcggctaatccaatccagttcactctaaataaggagaagctaaaagataaa
gaaaaggtatcaaaagaggaagaagagaaggagaggaacacagcagccatggtgtgctct
ttggagaatagagatgaatgtctgatgtgtggatcctga

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (3)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (2)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (3)   
   PROSITE (2)   
All databases (39)

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