KEGG   Homo sapiens (human): 6336Help
Entry
6336              CDS       T01001                                 

Gene name
SCN10A, FEPS2, Nav1.8, PN3, SNS, hPN3
Definition
sodium channel, voltage-gated, type X, alpha subunit
Orthology
K04842  
voltage-gated sodium channel type X alpha
Organism
hsa  Homo sapiens (human)
Disease
H01391  
Familial episodic pain syndrome (FEPS)
Drug target
Lidocaine: 
Tetracaine: 
Benzocaine: 
Cinchocaine: 
Procaine: 
Chloroprocaine: 
Bupivacaine: 
Mepivacaine: 
Prilocaine: 
Ropivacaine: 
Levobupivacaine: 
Cocaine: 
Dyclonine: 
Proxymetacaine: 
Other: 
Brite
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Na+ channel, SCN alpha, NaV1.x
   6336 (SCN10A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
Position
3p22.2
AA seq 1955 aa AA seqDB search
MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKAC
NQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIR
RTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLN
EFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI
HSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYIN
KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER
LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE
ALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSD
PYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLG
GGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEY
LDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFG
LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFD
PYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKII
GNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFL
IVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTA
PEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAEN
HIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSF
QQEVIPKGQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDT
SSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQV
RKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEM
LLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRAL
SRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLV
PLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRE
VNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKK
YYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQS
EEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILK
SLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
SIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPN
LPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDF
DMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCL
DILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKA
YRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSY
ESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP
NT seq 5868 nt NT seq  +upstreamnt  +downstreamnt
atggaattccccattggatccctcgaaactaacaacttccgtcgctttactccggagtca
ctggtggagatagagaagcaaattgctgccaagcagggaacaaagaaagccagagagaag
catagggagcagaaggaccaagaagagaagcctcggccccagctggacttgaaagcctgc
aaccagctgcccaagttctatggtgagctcccagcagaactgatcggggagcccctggag
gatctagatccgttctacagcacacaccggacatttatggtgctgaacaaagggaggacc
atttcccggtttagtgccactcgggccctgtggctattcagtcctttcaacctgatcaga
agaacggccatcaaagtgtctgtccactcgtggttcagtttatttattacggtcactatt
ttggttaattgtgtgtgcatgacccgaactgaccttccagagaaaattgaatatgtcttc
actgtcatttacacctttgaagccttgataaagatactggcaagaggattttgtctaaat
gagttcacgtacctgagagatccttggaactggctggattttagcgtcattaccctggca
tatgttggcacagcaatagatctccgtgggatctcaggcctgcggacattcagagttctt
agagcattaaaaacagtttctgtgatcccaggcctgaaggtcattgtgggggccctgatt
cactcagtgaagaaactggctgatgtgaccatcctcaccatcttctgcctaagtgttttt
gccttggtggggctgcaactcttcaagggcaacctcaaaaataaatgtgtcaagaatgac
atggctgtcaatgagacaaccaactactcatctcacagaaaaccagatatctacataaat
aagcgaggcacttctgaccccttactgtgtggcaatggatctgactcaggccactgccct
gatggttatatctgccttaaaacttctgacaacccggattttaactacaccagctttgat
tcctttgcttgggctttcctctcactgttccgcctcatgacacaggattcctgggaacgc
ctctaccagcagaccctgaggacttctgggaaaatctatatgatcttttttgtgctcgta
atcttcctgggatctttctacctggtcaacttgatcttggctgtagtcaccatggcgtat
gaggagcagaaccaggcaaccactgatgaaattgaagcaaaggagaagaagttccaggag
gccctcgagatgctccggaaggagcaggaggtgctagcagcactagggattgacacaacc
tctctccactcccacaatggatcacctttaacctccaaaaatgccagtgagagaaggcat
agaataaagccaagagtgtcagagggctccacagaagacaacaaatcaccccgctctgat
ccttacaaccagcgcaggatgtcttttctaggcctcgcctctggaaaacgccgggctagt
catggcagtgtgttccatttccggtcccctggccgagatatctcactccctgagggagtc
acagatgatggagtctttcctggagaccacgaaagccatcggggctctctgctgctgggt
gggggtgctggccagcaaggccccctccctagaagccctcttcctcaacccagcaaccct
gactccaggcatggagaagatgaacaccaaccgccgcccactagtgagcttgcccctgga
gctgtcgatgtctcggcattcgatgcaggacaaaagaagactttcttgtcagcagaatac
ttagatgaacctttccgggcccaaagggcaatgagtgttgtcagtatcataacctccgtc
cttgaggaactcgaggagtctgaacagaagtgcccaccctgcttgaccagcttgtctcag
aagtatctgatctgggattgctgccccatgtgggtgaagctcaagacaattctctttggg
cttgtgacggatccctttgcagagctcaccatcaccttgtgcatcgtggtgaacaccatc
ttcatggccatggagcaccatggcatgagccctaccttcgaagccatgctccagataggc
aacatcgtctttaccatattttttactgctgaaatggtcttcaaaatcattgccttcgac
ccatactattatttccagaagaagtggaatatctttgactgcatcatcgtcactgtgagt
ctgctagagctgggcgtggccaagaagggaagcctgtctgtgctgcggagcttccgcttg
ctgcgcgtattcaagctggccaaatcctggcccaccttaaacacactcatcaagatcatc
ggaaactcagtgggggcactggggaacctcaccatcatcctggccatcattgtctttgtc
tttgctctggttggcaagcagctcctaggggaaaactaccgtaacaaccgaaaaaatatc
tccgcgccccatgaagactggccccgctggcacatgcacgacttcttccactctttcctc
attgtcttccgtatcctctgtggagagtggattgagaacatgtgggcctgcatggaagtt
ggccaaaaatccatatgcctcatccttttcttgacggtgatggtgctagggaacctggtg
gtgcttaacctgttcatcgccctgctattgaactctttcagtgctgacaacctcacagcc
ccggaggacgatggggaggtgaacaacctgcaggtggccctggcacggatccaggtcttt
ggccatcgtaccaaacaggctctttgcagcttcttcagcaggtcctgcccattcccccag
cccaaggcagagcctgagctggtggtgaaactcccactctccagctccaaggctgagaac
cacattgctgccaacactgccagggggagctctggagggctccaagctcccagaggcccc
agggatgagcacagtgacttcatcgctaatccgactgtgtgggtctctgtgcccattgct
gagggtgaatctgatcttgatgacttggaggatgatggtggggaagatgctcagagcttc
cagcaggaagtgatccccaaaggacaggagcagctgcagcaagtcgagaggtgtggggac
cacctgacacccaggagcccaggcactggaacatcttctgaggacctggctccatccctg
ggtgagacgtggaaagatgagtctgttcctcaggtccctgctgagggagtggacgacaca
agctcctctgagggcagcacggtggactgcctagatcctgaggaaatcctgaggaagatc
cctgagctggcagatgacctggaagaaccagatgactgcttcacagaaggatgcattcgc
cactgtccctgctgcaaactggataccaccaagagtccatgggatgtgggctggcaggtg
cgcaagacttgctaccgtatcgtggagcacagctggtttgagagcttcatcatcttcatg
atcctgctcagcagtggatctctggcctttgaagactattacctggaccagaagcccacg
gtgaaagctttgctggagtacactgacagggtcttcacctttatctttgtgttcgagatg
ctgcttaagtgggtggcctatggcttcaaaaagtacttcaccaatgcctggtgctggctg
gacttcctcattgtgaatatctcactgataagtctcacagcgaagattctggaatattct
gaagtggctcccatcaaagcccttcgaacccttcgcgctctgcggccactgcgggctctt
tctcgatttgaaggcatgcgggtggtggtggatgccctggtgggcgccatcccatccatc
atgaatgtcctcctcgtctgcctcatcttctggctcatcttcagcatcatgggtgtgaac
ctcttcgcagggaagttttggaggtgcatcaactataccgatggagagttttcccttgta
cctttgtcgattgtgaataacaagtctgactgcaagattcaaaactccactggcagcttc
ttctgggtcaatgtgaaagtcaactttgataatgttgcaatgggttaccttgcacttctg
caggtggcaacctttaaaggctggatggacattatgtatgcagctgttgattcccgggag
gtcaacatgcaacccaagtgggaggacaacgtgtacatgtatttgtactttgtcatcttc
atcatttttggaggcttcttcacactgaatctctttgttggggtcataattgacaacttc
aatcaacagaaaaaaaagttagggggccaggacatcttcatgacagaggagcagaagaaa
tactacaatgccatgaagaagttgggctccaagaagccccagaagcccatcccacggccc
ctgaacaagttccagggttttgtctttgacatcgtgaccagacaagcttttgacatcacc
atcatggtcctcatctgcctcaacatgatcaccatgatggtggagactgatgaccaaagt
gaagaaaagacgaaaattctgggcaaaatcaaccagttctttgtggccgtcttcacaggc
gaatgtgtcatgaagatgttcgctttgaggcagtactacttcacaaatggctggaatgtg
tttgacttcattgtggtggttctctccattgcgagcctgattttttctgcaattcttaag
tcacttcaaagttacttctccccaacgctcttcagagtcatccgcctggcccgaattggc
cgcatcctcagactgatccgagcggccaaggggatccgcacactgctctttgccctcatg
atgtccctgcctgccctcttcaacatcgggctgttgctattccttgtcatgttcatctac
tctatcttcggtatgtccagctttccccatgtgaggtgggaggctggcatcgacgacatg
ttcaacttccagaccttcgccaacagcatgctgtgcctcttccagattaccacgtcggcc
ggctgggatggcctcctcagccccatcctcaacacagggcccccctactgtgaccccaat
ctgcccaacagcaatggcaccagaggggactgtgggagcccagccgtaggcatcatcttc
ttcaccacctacatcatcatctccttcctcatcatggtcaacatgtacattgcagtgatt
ctggagaacttcaatgtggccacggaggagagcactgagcccctgagtgaggacgacttt
gacatgttctatgagacctgggagaagtttgacccagaggccactcagtttattaccttt
tctgctctctcggactttgcagacactctctctggtcccctgagaatcccaaaacccaat
cgaaatatactgatccagatggacctgcctttggtccctggagataagatccactgcttg
gacatcctttttgctttcaccaagaatgtcctaggagaatccggggagttggattctctg
aaggcaaatatggaggagaagtttatggcaactaatctttcaaaatcatcctatgaacca
atagcaaccactctccgatggaagcaagaagacatttcagccactgtcattcaaaaggcc
tatcggagctatgtgctgcaccgctccatggcactctctaacaccccatgtgtgcccaga
gctgaggaggaggctgcatcactcccagatgaaggttttgttgcattcacagcaaatgaa
aattgtgtactcccagacaaatctgaaactgcttctgccacatcattcccaccgtcctat
gagagtgtcactagaggccttagtgatagagtcaacatgaggacatctagctcaatacaa
aatgaagatgaagccaccagtatggagctgattgcccctgggccctag

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