KEGG H.sapiens: 6470

Homo sapiens (human): 6470

Entry

6470 CDS H.sapiens

Gene name SHMT1

Definition serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1)

Orthology K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]

Pathway hsa00260 Glycine, serine and threonine metabolism
hsa00460 Cyanoamino acid metabolism
hsa00670 One carbon pool by folate
hsa00680 Methane metabolism
hsa01100 Metabolic pathways

Class Metabolism; Energy Metabolism; Methane metabolism [PATH:hsa00680]
Metabolism; Amino Acid Metabolism; Glycine, serine and threonine
metabolism [PATH:hsa00260]
Metabolism; Metabolism of Other Amino Acids; Cyanoamino acid
metabolism [PATH:hsa00460]
Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by
folate [PATH:hsa00670]

SSDB

Motif Pfam: SHMT Aminotran_1_2
PROSITE: SHMT

Other DBs NCBI-GI: 22547186
NCBI-GeneID: 6470
OMIM: 182144
HGNC: 10850
HPRD: 01643
Ensembl: ENSG00000176974
UniProt: P34896

Structure

PDB: 1BJ4

Position 17p11.2

AA seq 483 aa
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF

NT seq 1452 nt +upstreamnt +downstreamnt
atgacgatgccagtcaacggggcccacaaggatgctgacctgtggtcctcacatgacaag
atgctggcacaacccctcaaagacagtgatgttgaggtttacaacatcattaagaaggag
agtaaccggcagagggttggattggagctgattgcctcggagaatttcgccagccgagca
gttttggaggccctaggctcttgcttaaataacaaatactctgaggggtacccgggccag
agatactatggcgggactgagtttattgatgaactggagaccctctgtcagaagcgagcc
ctgcaggcctataagctggacccacagtgctggggggtcaacgtccagccctactcaggc
tcccctgcaaactttgctgtgtacactgccctggtggaaccccatgggcgcatcatgggc
ctggaccttccggatgggggccacctgacccatgggttcatgacagacaagaagaaaatc
tctgccacgtccatcttctttgaatctatgccctacaaggtgaacccagatactggctac
atcaactatgaccagctggaggagaacgcacgcctcttccacccgaagctgatcatcgca
ggaaccagctgctactcccgaaacctggaatatgcccggctacggaagattgcagatgag
aacggggcgtatctcatggcggacatggctcacatcagcgggctggtggcggctggcgtg
gtgccctccccatttgaacactgccatgtggtgaccaccaccactcacaagaccctgcga
ggctgccgagctggcatgatcttctacaggaaaggagtgaaaagtgtggatcccaagact
ggcaaagagattctgtacaacctggagtctcttatcaattctgctgtgttccctggcctg
cagggaggtccccacaaccacgccattgctggggttgctgtggcactgaagcaagctatg
actctggaatttaaagtttatcaacaccaggtggtggccaactgcagggctctgtctgag
gccctgacggagctgggctacaaaatagtcacaggtggttctgacaaccatttgatcctt
gtggatctccgttccaaaggcacagatggtggaagggctgagaaggtgctagaagcctgt
tctattgcctgcaacaagaacacctgtccaggtgacagaagcgctctgcggcccagtgga
ctgcggctggggaccccagcactgacgtcccgtggacttttggaaaaagacttccaaaaa
gtagcccactttattcacagagggatagagctgaccctgcagatccagagcgacactggt
gtcagagccaccctgaaagagttcaaggagagactggcaggggataagtaccaggcggcc
gtgcaggctctccgggaggaggttgagagcttcgcctctctcttccctctgcctggcctg
cctgacttctaa

All links

Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (10)   
   UNIGENE (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (10)   
   UniProt (1)   
   RefSeq(pep) (2)   
   IPI (7)   
DNA sequence (14)   
   RefSeq(nuc) (2)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (2)   
   PROSITE (1)   
All databases (53)

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