KEGG H.sapiens: 6472

Homo sapiens (human): 6472

Entry

6472 CDS H.sapiens

Gene name SHMT2

Definition serine hydroxymethyltransferase 2 (mitochondrial) (EC:2.1.2.1)

Orthology K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]

Pathway hsa00260 Glycine, serine and threonine metabolism
hsa00460 Cyanoamino acid metabolism
hsa00670 One carbon pool by folate
hsa00680 Methane metabolism
hsa01100 Metabolic pathways

Class Metabolism; Energy Metabolism; Methane metabolism [PATH:hsa00680]
Metabolism; Amino Acid Metabolism; Glycine, serine and threonine
metabolism [PATH:hsa00260]
Metabolism; Metabolism of Other Amino Acids; Cyanoamino acid
metabolism [PATH:hsa00460]
Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by
folate [PATH:hsa00670]

SSDB

Motif Pfam: SHMT
PROSITE: SHMT

Other DBs NCBI-GI: 261862346
NCBI-GeneID: 6472
OMIM: 138450
HGNC: 10852
HPRD: 00717
Ensembl: ENSG00000182199
UniProt: Q8N1A5

Structure

PDB: 2A7V

Position 12q12-q14

AA seq 494 aa
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL
QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLA
DMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYT
FEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGY
SLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPA
LTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVE
QFARAFPMPGFDEH

NT seq 1485 nt +upstreamnt +downstreamnt
atgctgtacttctctttgttttgggcggctcggcctctgcagagatgtgggcagctggtc
aggatggccattcgggctcagcacagcaacgcagcccagactcagactggggaagcaaac
aggggctggacaggccaggagagcctgtcggacagtgatcctgagatgtgggagttgctg
cagagggagaaggacaggcagtgtcgtggcctggagctcattgcctcagagaacttctgc
agccgagctgcgctggaggccctggggtcctgtctgaacaacaagtactcggagggttat
cctggcaagagatactatgggggagcagaggtggtggatgaaattgagctgctgtgccag
cgccgggccttggaagcctttgacctggatcctgcacagtggggagtcaatgtccagccc
tactccgggtccccagccaacctggccgtctacacagcccttctgcaacctcacgaccgg
atcatggggctggacctgcccgatgggggccatctcacccacggctacatgtctgacgtc
aagcggatatcagccacgtccatcttcttcgagtctatgccctataagctcaacctggca
ctgactgctcgacttttccggccacggctcatcatagctggcaccagcgcctatgctcgc
ctcattgactacgcccgcatgagagaggtgtgtgatgaagtcaaagcacacctgctggca
gacatggcccacatcagtggcctggtggctgccaaggtgattccctcgcctttcaagcac
gcggacatcgtcaccaccactactcacaagactcttcgaggggccaggtcagggctcatc
ttctaccggaaaggggtgaaggctgtggaccccaagactggccgggagatcccttacaca
tttgaggaccgaatcaactttgccgtgttcccatccctgcaggggggcccccacaatcat
gccattgctgcagtagctgtggccctaaagcaggcctgcacccccatgttccgggagtac
tccctgcaggttctgaagaatgctcgggccatggcagatgccctgctagagcgaggctac
tcactggtatcaggtggtactgacaaccacctggtgctggtggacctgcggcccaagggc
ctggatggagctcgggctgagcgggtgctagagcttgtatccatcactgccaacaagaac
acctgtcctggagaccgaagtgccatcacaccgggcggcctgcggcttggggccccagcc
ttaacttctcgacagttccgtgaggatgacttccggagagttgtggactttatagatgaa
ggggtcaacattggcttagaggtgaagagcaagactgccaagctccaggatttcaaatcc
ttcctgcttaaggactcagaaacaagtcagcgtctggccaacctcaggcaacgggtggag
cagtttgccagggccttccccatgcctggttttgatgagcattga

All links

Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (12)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (21)   
   UniProt (2)   
   RefSeq(pep) (5)   
   IPI (14)   
DNA sequence (13)   
   RefSeq(nuc) (5)   
   GenBank (4)   
   EMBL (4)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (63)

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