KEGG H.sapiens: 6718

Homo sapiens (human): 6718

Entry

6718 CDS H.sapiens

Gene name AKR1D1

Definition aldo-keto reductase family 1, member D1 (delta
4-3-ketosteroid-5-beta-reductase) (EC:1.3.1.3)

Orthology K00251 3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]

Pathway hsa00120 Primary bile acid biosynthesis
hsa00140 Steroid hormone biosynthesis
hsa01100 Metabolic pathways

Class Metabolism; Lipid Metabolism; Primary bile acid biosynthesis
[PATH:hsa00120]
Metabolism; Lipid Metabolism; Steroid hormone biosynthesis
[PATH:hsa00140]

SSDB

Motif Pfam: Aldo_ket_red DUF711
PROSITE: ALDOKETO_REDUCTASE_2 ALDOKETO_REDUCTASE_1
ALDOKETO_REDUCTASE_3

Other DBs NCBI-GI: 5174695
NCBI-GeneID: 6718
OMIM: 604741
HGNC: 388
HPRD: 07263
Ensembl: ENSG00000122787
UniProt: P51857

Structure

PDB: 3BUV 3BUR 3G1R 3BV7 3CMF 3CAV 3DOP 3CAS
3COT 3CAQ

Position 7q32-q33

AA seq 326 aa
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE
ALNKNVRFVELLMWRDHPEYPFHDEY

NT seq 981 nt +upstreamnt +downstreamnt
atggatctcagtgctgcaagtcaccgcatacctctaagtgatggaaacagcattcccatc
atcggacttggtacctactcagaacctaaatcgacccctaagggagcctgtgcaacatcg
gtgaaggttgctattgacacagggtaccgacatattgatggggcctacatctaccaaaat
gaacacgaagttggggaggccatcagggagaagatagcagaaggaaaggtgcggagggaa
gatatcttctactgtggaaagctatgggctacaaatcatgtcccagagatggtccgccca
accctggagaggacactcagggtcctccagctagattatgtggatctttacatcattgaa
gtacccatggcctttaagccaggagatgaaatataccctagagatgagaatggcaaatgg
ttatatcacaagtcaaatctgtgtgccacttgggaggcgatggaagcttgcaaagacgct
ggcttggtgaaatccctgggagtgtccaattttaaccgcaggcagctggagctcatcctg
aacaagccaggactcaaacacaagccagtcagcaaccaggttgagtgccatccgtatttc
acccagccaaaactcttgaaattttgccaacaacatgacattgtcattactgcatatagc
cctttggggaccagtaggaatccaatctgggtgaatgtttcttctccacctttgttaaag
gatgcacttctaaactcattggggaaaaggtacaataagacagcagctcaaattgttttg
cgtttcaacatccagcgaggggtggttgtcattcctaaaagctttaatcttgaaaggatc
aaagaaaattttcagatctttgacttttctctcactgaagaagaaatgaaggacattgaa
gccttgaataaaaatgtccgctttgtagaattgctcatgtggcgcgatcatcctgaatac
ccatttcatgatgaatactga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (7)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (5)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (10)   
   PDB (10)   
Protein domain (5)   
   Pfam (2)   
   PROSITE (3)   
All databases (66)

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