KEGG H.sapiens: 7372

Homo sapiens (human): 7372

Entry

7372 CDS H.sapiens

Gene name UMPS

Definition uridine monophosphate synthetase (EC:2.4.2.10 4.1.1.23)

Orthology K00762 orotate phosphoribosyltransferase [EC:2.4.2.10]
K01591 orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]

Pathway hsa00240 Pyrimidine metabolism
hsa00983 Drug metabolism - other enzymes
hsa01100 Metabolic pathways

Disease H00198 Orotic aciduria

Class Metabolism; Nucleotide Metabolism; Pyrimidine metabolism
[PATH:hsa00240]
Metabolism; Xenobiotics Biodegradation and Metabolism; Drug
metabolism - other enzymes [PATH:hsa00983]

SSDB

Motif Pfam: OMPdecase Pribosyltran
PROSITE: PUR_PYR_PR_TRANSFER OMPDECASE

Other DBs NCBI-GI: 4507835
NCBI-GeneID: 7372
OMIM: 258900
HGNC: 12563
HPRD: 02022
Ensembl: ENSG00000114491
UniProt: A8K5J1 P11172

Structure

PDB: 3EWW 3EWY 2QCF 3EX4 3EX6 3L0K 3G3M 3EWX
     3EWZ 3EX1 2QCE 3EX3 3DBP 3EX2 3EWU 3BK0
     2QCM 3G3D 3L0N 2QCG 2P1F 3BVJ 2QCC 2QCL
     2QCN 2WNS 3BGG 2QCH 2JGY 3BGJ 2QCD 2EAW
     2V30

Position 3q13

AA seq 480 aa
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV

NT seq 1443 nt +upstreamnt +downstreamnt
atggcggtcgctcgtgcagctttggggccattggtgacgggtctgtacgacgtgcaggct
ttcaagtttggggacttcgtgctgaagagcgggctttcctcccccatctacatcgatctg
cggggcatcgtgtctcgaccgcgtcttctgagtcaggttgcagatattttattccaaact
gcccaaaatgcaggcatcagttttgacaccgtgtgtggagtgccttatacagctttgcca
ttggctacagttatctgttcaaccaatcaaattccaatgcttattagaaggaaagaaaca
aaggattatggaactaagcgtcttgtagaaggaactattaatccaggagaaacctgttta
atcattgaagatgttgtcaccagtggatctagtgttttggaaactgttgaggttcttcag
aaggagggcttgaaggtcactgatgccatagtgctgttggacagagagcagggaggcaag
gacaagttgcaggcgcacgggatccgcctccactcagtgtgtacattgtccaaaatgctg
gagattctcgagcagcagaaaaaagttgatgctgagacagttgggagagtgaagaggttt
attcaggagaatgtctttgtggcagcgaatcataatggttctcccctttctataaaggaa
gcacccaaagaactcagcttcggtgcacgtgcagagctgcccaggatccacccagttgca
tcgaagcttctcaggcttatgcaaaagaaggagaccaatctgtgtctatctgctgatgtt
tcactggccagagagctgttgcagctagcagatgctttaggacctagtatctgcatgctg
aagactcatgtagatattttgaatgattttactctggatgtgatgaaggagttgataact
ctggcaaaatgccatgagttcttgatatttgaagaccggaagtttgcagatataggaaac
acagtgaaaaagcagtatgaaggaggtatctttaaaatagcttcctgggcagatctagta
aatgctcacgtggtgccaggctcaggagttgtgaaaggcctgcaagaagtgggcctgcct
ttgcatcgggggtgcctccttattgcggaaatgagctccaccggctccctggccactggg
gactacactagagcagcggttagaatggctgaggagcactctgaatttgttgttggtttt
atttctggctcccgagtaagcatgaaaccagaatttcttcacttgactccaggagttcag
ttggaagcaggaggagataatcttggccaacagtacaatagcccacaagaagttattggc
aaacgaggttccgatatcatcattgtaggtcgtggcataatctcagcagctgatcgtctg
gaagcagcagagatgtacagaaaagctgcttgggaagcgtatttgagtagacttggtgtt
tga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (2)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (11)   
   UniProt (2)   
   RefSeq(pep) (1)   
   IPI (8)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
3D Structure (33)   
   PDB (33)   
Protein domain (4)   
   Pfam (2)   
   PROSITE (2)   
All databases (79)

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