KEGG   Homo sapiens (human): 4124
Entry
4124              CDS       T01001                                 
Symbol
MAN2A1, AMan_II, GOLIM7, MANA2, MANII
Name
(RefSeq) mannosidase alpha class 2A member 1
  KO
K01231  alpha-mannosidase II [EC:3.2.1.114]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00075  N-glycan biosynthesis, complex type
Network
nt06015  N-Glycan biosynthesis
  Element
N00820  N-Glycan biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    4124 (MAN2A1)
   00513 Various types of N-glycan biosynthesis
    4124 (MAN2A1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.114  mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
     4124 (MAN2A1)
SSDB
Motif
Pfam: Glyco_hydro_38N Glyco_hydro_38C Alpha-mann_mid Laman-like_dom Glyco_hydro_57
Other DBs
NCBI-GeneID: 4124
NCBI-ProteinID: NP_002363
OMIM: 154582
HGNC: 6824
Ensembl: ENSG00000112893
UniProt: Q16706
Position
5:109689927..109869625
AA seq 1144 aa
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR
NT seq 3435 nt   +upstreamnt  +downstreamnt
atgaagttaagccgccagttcaccgtgttcggcagtgcgatcttctgtgtggtgattttc
tcgctctacctgatgctggaccggggtcacttagactaccccaggaacccgcgccgcgag
ggctccttccctcagggccagctctcaatgttgcaagaaaaaatagaccatttggagcgt
ttgctagctgagaataatgagatcatctcaaatattagagactcagtcatcaatttgagt
gagtctgtggaggatggtccgaaaagttcacaaagcaatttcagccaaggtgctggctca
catcttctgccctcacaattatccctctcagttgacactgcagactgtctgtttgcttca
caaagtggaagtcacaattcagatgtgcagatgttggatgtttacagtctaatttctttt
gacaatccagatggtggagtttggaagcaaggatttgacattacttatgaatctaatgaa
tgggacactgaaccccttcaagtctttgtggtgcctcattcccataacgacccaggttgg
ttgaagactttcaatgactactttagagacaagactcagtatatttttaataacatggtc
ctaaagctgaaagaagactcacggaggaagtttatttggtctgagatctcttacctttca
aagtggtgggatattatagatattcagaagaaggatgctgttaaaagtttaatagaaaat
ggtcagcttgaaattgtgacaggtggctgggttatgcctgatgaagctactccacattat
tttgccttaattgatcaactaattgaaggacatcagtggctggaaaataatataggagtg
aaacctcggtccggctgggctattgatccctttggacactcaccaacaatggcttatctt
ctaaaccgtgctggactttctcacatgcttatccagagagttcattatgcagttaaaaaa
cactttgcactgcataaaacattggagtttttttggagacagaattgggatctgggatct
gtcacagatattttatgccacatgatgcccttctacagctatgacatccctcacacttgt
ggacctgatcctaaaatatgctgccagtttgattttaaacgtcttcctggaggcagattt
ggttgtccctggggagtccccccagaaacaatacatcctggaaatgtccaaagcagggct
cggatgctactagatcagtaccgaaagaagtcaaagctttttcgtaccaaagttctcctg
gctccactaggagatgatttccgctactgtgaatacacggaatgggatttacagtttaag
aattatcagcagctttttgattatatgaattctcagtccaagtttaaagttaagatacag
tttggaactttatcagatttttttgatgcgctggataaagcagatgaaactcagagagac
aagggccaatcgatgttccctgttttaagtggagattttttcacttatgccgatcgagat
gatcattactggagtggctattttacatccagacccttttacaaacgaatggacagaatc
atggaatctcatttaagggctgctgaaattctttactatttcgccctgagacaagctcac
aaatacaagataaataaatttctctcatcatcactttacacggcactgacagaagccaga
aggaatttgggactgtttcaacatcatgatgctatcacaggaactgcaaaagactgggtg
gttgtggattatggtaccagactttttcattcgttaatggttttggagaagataattgga
aattctgcatttcttcttattttgaaggacaaactcacatacgactcttactctcctgat
accttcctggagatggatttgaaacaaaaatcacaagattctctgccacaaaaaaatata
ataaggctgagtgcggagccaaggtaccttgtggtctataatcctttagaacaagaccga
atctcgttggtctcagtctatgtgagttccccgacagtgcaagtgttctctgcttcagga
aaacctgtggaagttcaagtcagcgcagtttgggatacagcaaatactatttcagaaaca
gcctatgagatctcttttcgagcacatataccgccattgggactgaaagtgtataagatt
ttggaatcagcaagttcaaattcacatttagctgattatgtcttgtataagaataaagta
gaagatagcggaattttcaccataaagaatatgataaatactgaagaaggtataacacta
gagaactcctttgttttacttcggtttgatcaaactggacttatgaagcaaatgatgact
aaagaagatggtaaacaccatgaagtaaatgtgcaattttcatggtatggaaccacaatt
aaaagagacaaaagtggtgcctacctcttcttacctgatggtaatgccaagccttatgtt
tacacaacaccgccctttgtcagagtgacacatggaaggatttattcggaagtgacttgc
ttttttgaccatgttactcatagagtccgactataccacatacagggaatagaaggacag
tctgtggaagtttccaatattgtggacatccgaaaagtatataaccgtgagattgcaatg
aaaatttcttctgatataaaaagccaaaatagattttatactgacctaaatgggtaccag
attcaacctagaatgacactgagcaaattgcctcttcaagcaaatgtctatcccatgacc
acaatggcctatatccaggatgccaaacatcgtttgacactgctctctgctcagtcatta
ggggtttcgagtttgaatagtggtcagattgaagttatcatggatcgaagactcatgcaa
gatgataatcgtggccttgagcaaggtatccaggataacaagattacagctaatctattt
cgaatactactagaaaaaagaagtgctgttaatacggaagaagaaaagaagtcggtcagt
tatccttctctccttagccacataacttcttctctcatgaatcatccagtcattccaatg
gcaaataagttctcctcacctacccttgagctgcaaggtgaattctctccattacagtca
tctttgccttgtgacattcatctggttaatttgagaacaatacagtcaaaggtgggcaat
gggcactccaatgaggcagccttgatcctccacagaaaagggtttgattgtcggttctct
agcaaaggcacagggctgttttgttctactactcagggaaagatattggtacagaaactt
ttaaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgcattcacct
cccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagcacattccga
atccagttgaggtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (37)   
   RefSeq(nuc) (9)   
   GenBank (14)   
   EMBL (14)   
Protein domain (5)   
   Pfam (5)   
All databases (76)   

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