KEGG   PATHWAY: hsa00010Help
Entry
hsa00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Homo sapiens (human)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
hsa00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:hsa00010]
Glycolysis, core module involving three-carbon compounds [PATH:hsa00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:hsa00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00010]
Disease
H00069  
Glycogen storage diseases (GSD)
H00071  
Hereditary fructose intolerance
H00072  
Pyruvate dehydrogenase complex deficiency
H00114  
Fructose-1,6-bisphosphatase deficiency
H00664  
Anemia due to disorders of glycolytic enzymes
H01071  
Acute alcohol sensitivity
H01096  
Pyruvate kinase (PK) deficiency
H01267  
Familial hyperinsulinemic hypoglycemia (HHF)
Drug
D00123  
Cyanamide (JP16)
D00131  
Disulfiram (JP16/USP/INN)
D00707  
Fomepizole (JAN/USAN/INN)
D08970  
Piragliatin (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
3101  
HK3; hexokinase 3 (white cell) [KO:K00844] [EC:2.7.1.1]
3098  
HK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]
3099  
HK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]
80201  
HKDC1; hexokinase domain containing 1 [KO:K00844] [EC:2.7.1.1]
2645  
GCK; glucokinase (hexokinase 4) [KO:K12407] [EC:2.7.1.2]
2821  
GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
5213  
PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
5214  
PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
5211  
PFKL; phosphofructokinase, liver [KO:K00850] [EC:2.7.1.11]
2203  
FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
8789  
FBP2; fructose-1,6-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
230  
ALDOC; aldolase C, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
226  
ALDOA; aldolase A, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
229  
ALDOB; aldolase B, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
7167  
TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]
2597  
GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
26330  
GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [KO:K10705] [EC:1.2.1.12]
5232  
PGK2; phosphoglycerate kinase 2 [KO:K00927] [EC:2.7.2.3]
5230  
PGK1; phosphoglycerate kinase 1 [KO:K00927] [EC:2.7.2.3]
5223  
PGAM1; phosphoglycerate mutase 1 (brain) [KO:K01834] [EC:5.4.2.11]
5224  
PGAM2; phosphoglycerate mutase 2 (muscle) [KO:K01834] [EC:5.4.2.11]
441531  
PGAM4; phosphoglycerate mutase family member 4 [KO:K01834] [EC:5.4.2.11]
2027  
ENO3; enolase 3 (beta, muscle) [KO:K01689] [EC:4.2.1.11]
2026  
ENO2; enolase 2 (gamma, neuronal) [KO:K01689] [EC:4.2.1.11]
2023  
ENO1; enolase 1, (alpha) [KO:K01689] [EC:4.2.1.11]
5315  
PKM; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
5313  
PKLR; pyruvate kinase, liver and RBC [KO:K12406] [EC:2.7.1.40]
5161  
PDHA2; pyruvate dehydrogenase (lipoamide) alpha 2 [KO:K00161] [EC:1.2.4.1]
5160  
PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1 [KO:K00161] [EC:1.2.4.1]
5162  
PDHB; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
1737  
DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
1738  
DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
160287  
LDHAL6A; lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
92483  
LDHAL6B; lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
3939  
LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
3945  
LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
3948  
LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
124  
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  
ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
130  
ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
10327  
AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase) [KO:K00002] [EC:1.1.1.2]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
221  
ALDH3B1; aldehyde dehydrogenase 3 family, member B1 [KO:K00129] [EC:1.2.1.5]
222  
ALDH3B2; aldehyde dehydrogenase 3 family, member B2 [KO:K00129] [EC:1.2.1.5]
220  
ALDH1A3; aldehyde dehydrogenase 1 family, member A3 [KO:K00129] [EC:1.2.1.5]
218  
ALDH3A1; aldehyde dehydrogenase 3 family, member A1 [KO:K00129] [EC:1.2.1.5]
84532  
ACSS1; acyl-CoA synthetase short-chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902  
ACSS2; acyl-CoA synthetase short-chain family member 2 [KO:K01895] [EC:6.2.1.1]
130589  
GALM; galactose mutarotase (aldose 1-epimerase) [KO:K01785] [EC:5.1.3.3]
5236  
PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
55276  
PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.7 5.4.2.2]
2538  
G6PC; glucose-6-phosphatase, catalytic subunit [KO:K01084] [EC:3.1.3.9]
57818  
G6PC2; glucose-6-phosphatase, catalytic, 2 [KO:K01084] [EC:3.1.3.9]
92579  
G6PC3; glucose 6 phosphatase, catalytic, 3 [KO:K01084] [EC:3.1.3.9]
83440  
ADPGK; ADP-dependent glucokinase [KO:K08074] [EC:2.7.1.147]
669  
BPGM; 2,3-bisphosphoglycerate mutase [KO:K01837] [EC:3.1.3.13 5.4.2.11 5.4.2.4]
5105  
PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
5106  
PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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