KEGG PATHWAY: hsa00071

PATHWAY: hsa00071

Entry

hsa00071 Pathway

Name

Fatty acid metabolism - Homo sapiens (human)

Class

Metabolism; Lipid metabolism

Pathway map

hsa00071

Fatty acid metabolism

Module

hsa_M00086	beta-Oxidation, acyl-CoA synthesis [PATH:hsa00071]
hsa_M00087	beta-Oxidation [PATH:hsa00071]

Disease

H00162	Sjogren-Larsson syndrome
H00178	Glutaric acidemia
H00407	Peroxisomal beta-oxidation enzyme deficiency
H00525	Disorders of fatty-acid oxidation
H01267	Familial hyperinsulinemic hypoglycemia (HHF)

Drug

D00123	Cyanamide (JP16)
D00131	Disulfiram (JP16/USP/INN)
D00707	Fomepizole (JAN/USAN/INN)
D05292	Oxfenicine (USAN/INN)

Organism

Homo sapiens (human) [GN:hsa]

Gene

39	ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38	ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
30	ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
10449	ACAA2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]
3032	HADHB; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [KO:K07509] [EC:2.3.1.16]
3033	HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
3030	HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]
1962	EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
1892	ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
8310	ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
51	ACOX1; acyl-CoA oxidase 1, palmitoyl [KO:K00232] [EC:1.3.3.6]
35	ACADS; acyl-CoA dehydrogenase, C-2 to C-3 short chain [KO:K00248] [EC:1.3.8.1]
34	ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
33	ACADL; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
36	ACADSB; acyl-CoA dehydrogenase, short/branched chain [KO:K09478] [EC:1.3.99.12]
37	ACADVL; acyl-CoA dehydrogenase, very long chain [KO:K09479] [EC:1.3.8.9]
2639	GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
23305	ACSL6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
2182	ACSL4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
2180	ACSL1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
51703	ACSL5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
2181	ACSL3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
23205	ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
81616	ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
1374	CPT1A; carnitine palmitoyltransferase 1A (liver) [KO:K08765] [EC:2.3.1.21]
1375	CPT1B; carnitine palmitoyltransferase 1B (muscle) [KO:K08765] [EC:2.3.1.21]
126129	CPT1C; carnitine palmitoyltransferase 1C [KO:K08765] [EC:2.3.1.21]
1376	CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
1632	ECI1; enoyl-CoA delta isomerase 1 [KO:K13238] [EC:5.3.3.8]
10455	ECI2; enoyl-CoA delta isomerase 2 [KO:K13239] [EC:5.3.3.8]
1579	CYP4A11; cytochrome P450, family 4, subfamily A, polypeptide 11 [KO:K07425] [EC:1.14.15.3]
284541	CYP4A22; cytochrome P450, family 4, subfamily A, polypeptide 22 [KO:K07425] [EC:1.14.15.3]
124	ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125	ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126	ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131	ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127	ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128	ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
130	ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
217	ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224	ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
219	ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
501	ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223	ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]

Compound

C00010	CoA
C00024	Acetyl-CoA
C00071	Aldehyde
C00136	Butanoyl-CoA
C00154	Palmitoyl-CoA
C00162	Fatty acid
C00173	Acyl-[acyl-carrier protein]
C00226	Primary alcohol
C00229	Acyl-carrier protein
C00249	Hexadecanoic acid
C00332	Acetoacetyl-CoA
C00340	Reduced rubredoxin
C00435	Oxidized rubredoxin
C00489	Glutarate
C00517	Hexadecanal
C00527	Glutaryl-CoA
C00638	Long-chain fatty acid
C00823	1-Hexadecanol
C00877	Crotonoyl-CoA
C01144	(S)-3-Hydroxybutanoyl-CoA
C01371	Alkane
C01832	Lauroyl-CoA
C01944	Octanoyl-CoA
C02593	Tetradecanoyl-CoA
C02990	L-Palmitoylcarnitine
C03221	2-trans-Dodecenoyl-CoA
C03547	omega-Hydroxy fatty acid
C03561	(R)-3-Hydroxybutanoyl-CoA
C05102	alpha-Hydroxy fatty acid
C05258	(S)-3-Hydroxyhexadecanoyl-CoA
C05259	3-Oxopalmitoyl-CoA
C05260	(S)-3-Hydroxytetradecanoyl-CoA
C05261	3-Oxotetradecanoyl-CoA
C05262	(S)-3-Hydroxydodecanoyl-CoA
C05263	3-Oxododecanoyl-CoA
C05264	(S)-Hydroxydecanoyl-CoA
C05265	3-Oxodecanoyl-CoA
C05266	(S)-3-Hydroxyoctanoyl-CoA
C05267	3-Oxooctanoyl-CoA
C05268	(S)-Hydroxyhexanoyl-CoA
C05269	3-Oxohexanoyl-CoA
C05270	Hexanoyl-CoA
C05271	trans-Hex-2-enoyl-CoA
C05272	trans-Hexadec-2-enoyl-CoA
C05273	trans-Tetradec-2-enoyl-CoA
C05274	Decanoyl-CoA
C05275	trans-Dec-2-enoyl-CoA
C05276	trans-Oct-2-enoyl-CoA
C05279	trans,cis-Lauro-2,6-dienoyl-CoA
C05280	cis,cis-3,6-Dodecadienoyl-CoA

Reference

PMID:869535

Authors

Parekh VR, Traxler RW, Sobek JM

Title

N-Alkane oxidation enzymes of a pseudomonad.

Journal

Appl Environ Microbiol 33:881-4 (1977)

KO pathway

ko00071

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG MODULE (2)   
   BioSystems (1)   
Disease (5)   
   KEGG DISEASE (5)   
Drug (4)   
   KEGG DRUG (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG GENES (44)   
All databases (58)   

Download RDF

DBGET integrated database retrieval system