KEGG   PATHWAY: hsa00561Help
Entry
hsa00561                    Pathway                                

Name
Glycerolipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Glycerolipid metabolism
hsa00561

All organismsOrtholog table
Module
Triacylglycerol biosynthesis [PATH:hsa00561]
Acylglycerol degradation [PATH:hsa00561]
Disease
H00154  
Hyperlipoproteinemia, type I
H00552  
Glycerol kinase deficiency (GKD)
H01117  
Majeed syndrome
H01290  
Acute recurrent myoglobinuria
H01333  
Nonalcoholic fatty liver disease (NAFLD)
Drug
D00123  
Cyanamide (JP16)
D00131  
Disulfiram (JP16/USP/INN)
D03747  
Ibrolipim (USAN/INN)
Other DBs
Organism
Homo sapiens (human) [GN:hsa]
Gene
132158  
GLYCTK; glycerate kinase [KO:K15788] [EC:2.7.1.31]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
231  
AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
57016  
AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
10327  
AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase) [KO:K00002] [EC:1.1.1.2]
26007  
DAK; dihydroxyacetone kinase 2 homolog (S. cerevisiae) [KO:K00863] [EC:2.7.1.29]
2712  
GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
2710  
GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
57678  
GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
150763  
GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
137964  
AGPAT6; 1-acylglycerol-3-phosphate O-acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
84803  
AGPAT9; 1-acylglycerol-3-phosphate O-acyltransferase 9 [KO:K13506] [EC:2.3.1.15]
10554  
AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
10555  
AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
253558  
LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.51 2.3.1.-]
154141  
MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
129642  
MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.- 2.3.1.51]
56894  
AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
56895  
AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.- 2.3.1.51]
8611  
PPAP2A; phosphatidic acid phosphatase type 2A [KO:K01080] [EC:3.1.3.4]
8613  
PPAP2B; phosphatidic acid phosphatase type 2B [KO:K01080] [EC:3.1.3.4]
8612  
PPAP2C; phosphatidic acid phosphatase type 2C [KO:K01080] [EC:3.1.3.4]
23175  
LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64900  
LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
9663  
LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
8525  
DGKZ; diacylglycerol kinase, zeta [KO:K00901] [EC:2.7.1.107]
8527  
DGKD; diacylglycerol kinase, delta 130kDa [KO:K00901] [EC:2.7.1.107]
9162  
DGKI; diacylglycerol kinase, iota [KO:K00901] [EC:2.7.1.107]
1606  
DGKA; diacylglycerol kinase, alpha 80kDa [KO:K00901] [EC:2.7.1.107]
8526  
DGKE; diacylglycerol kinase, epsilon 64kDa [KO:K00901] [EC:2.7.1.107]
1607  
DGKB; diacylglycerol kinase, beta 90kDa [KO:K00901] [EC:2.7.1.107]
160851  
DGKH; diacylglycerol kinase, eta [KO:K00901] [EC:2.7.1.107]
1608  
DGKG; diacylglycerol kinase, gamma 90kDa [KO:K00901] [EC:2.7.1.107]
1609  
DGKQ; diacylglycerol kinase, theta 110kDa [KO:K00901] [EC:2.7.1.107]
8694  
DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.76 2.3.1.75 2.3.1.20]
84649  
DGAT2; diacylglycerol O-acyltransferase 2 [KO:K11160] [EC:2.3.1.75 2.3.1.20]
346606  
MOGAT3; monoacylglycerol O-acyltransferase 3 [KO:K14456] [EC:2.3.1.22 2.3.1.20]
9388  
LIPG; lipase, endothelial [KO:K01046] [EC:3.1.1.3]
3990  
LIPC; lipase, hepatic [KO:K01046] [EC:3.1.1.3]
1056  
CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
57104  
PNPLA2; patatin-like phospholipase domain containing 2 [KO:K16816] [EC:3.1.1.3]
80339  
PNPLA3; patatin-like phospholipase domain containing 3 [KO:K13534] [EC:2.3.1.- 3.1.1.3]
5406  
PNLIP; pancreatic lipase [KO:K14073] [EC:3.1.1.3]
5407  
PNLIPRP1; pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
5408  
PNLIPRP2; pancreatic lipase-related protein 2 [KO:K14075] [EC:3.1.1.3]
119548  
PNLIPRP3; pancreatic lipase-related protein 3 [KO:K14076] [EC:3.1.1.3]
8513  
LIPF; lipase, gastric [KO:K14452] [EC:3.1.1.3]
4023  
LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
55750  
AGK; acylglycerol kinase [KO:K09881] [EC:2.7.1.94]
11343  
MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
2717  
GLA; galactosidase, alpha [KO:K01189] [EC:3.2.1.22]
Compound
C00029  
UDP-glucose
C00040  
Acyl-CoA
C00093  
sn-Glycerol 3-phosphate
C00111  
Glycerone phosphate
C00116  
Glycerol
C00162  
Fatty acid
C00184  
Glycerone
C00197  
3-Phospho-D-glycerate
C00258  
D-Glycerate
C00416  
Phosphatidate
C00422  
Triacylglycerol
C00577  
D-Glyceraldehyde
C00641  
1,2-Diacyl-sn-glycerol
C00681  
1-Acyl-sn-glycerol 3-phosphate
C00969  
3-Hydroxypropanal
C01885  
1-Acylglycerol
C02457  
Propane-1,3-diol
C03692  
1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
C04046  
3-D-Glucosyl-1,2-diacylglycerol
C04315  
2-Acyl-3-O-(beta-D-galactosyl)-sn-glycerol
C04872  
1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
C05401  
3-beta-D-Galactosyl-sn-glycerol
C06037  
Digalactosyl-diacylglycerol
C06038  
Acyl1-monogalactosyl-diacylglycerol
C06040  
Diglucosyl-diacylglycerol
C06041  
Glycerophosphoglycoglycerolipid
C11521  
UDP-6-sulfoquinovose
C13508  
Sulfoquinovosyldiacylglycerol
Reference
PMID:8662716
  Authors
Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L.
  Title
Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway.
  Journal
J Biol Chem 271:13875-81 (1996)
Reference
PMID:8995384
  Authors
Karlsson OP, Dahlqvist A, Vikstrom S, Wieslander A.
  Title
Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii.
  Journal
J Biol Chem 272:929-36 (1997)
Reference
  Authors
Berg S, Edman M, Li L, Wikstrom M, Wieslander A.
  Title
Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea.
  Journal
J Biol Chem 276:22056-63 (2001)
KO pathway
 

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