KEGG   PATHWAY: hsa00590Help
Entry
hsa00590                    Pathway                                

Name
Arachidonic acid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Arachidonic acid metabolism
hsa00590

All organismsOrtholog table
Disease
H00490  
Diaphyseal dysplasia with anemia (Ghosal)
H00734  
Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
Drug
D00109  
Aspirin (JP16/USP)
D00118  
Naproxen (JP16/USP/INN)
D00120  
Sulindac (JP16/USP/INN)
D00126  
Ibuprofen (JP16/USP/INN)
D00127  
Piroxicam (JP16/USP/INN)
D00130  
Diflunisal (JAN/USP/INN)
D00132  
Ketoprofen (JP16/USP/INN)
D00141  
Indometacin (JP16/INN)
D00151  
Mefenamic acid (JP16/USP/INN)
D00158  
Tolmetin sodium (JAN/USP)
D00169  
Meclofenamate sodium (USP)
D00315  
Etodolac (JP16/USP/INN)
D00330  
Flurbiprofen (JP16/USP/INN)
D00414  
Zileuton (USP/INN)
D00425  
Nabumetone (JP16/USP/INN)
D00428  
Sasapyrine (JAN)
D00463  
Oxaprozin (JP16/USAN/INN)
D00510  
Phenylbutazone (JP16/USP/INN)
D00566  
Sodium salicylate (JP16/USP)
D00567  
Celecoxib (JAN/USAN/INN)
D00568  
Rofecoxib (JAN/USAN/INN)
D00810  
Choline salicylate (JAN/USAN/INN)
D00813  
Ketorolac tromethamine (USP)
D00827  
Magnesium salicylate (USP)
D00903  
Diclofenac potassium (USAN)
D00904  
Diclofenac sodium (JP16/USP)
D00968  
Fenoprofen calcium (JAN/USP)
D00969  
Meloxicam (JAN/USAN/INN)
D00970  
Naproxen sodium (USP)
D01049  
Nimesulide (JAN/INN)
D01122  
Ibuprofen piconol (JP16/USAN)
D01183  
Tolfenamic acid (JAN/INN)
D01220  
Trapidil (JP16/INN)
D01267  
Floctafenine (JAN/USAN/INN)
D01325  
Tiaprofenic acid (JAN/INN)
D01397  
Ampiroxicam (JAN/INN)
D01410  
Benzydamine hydrochloride (JAN/USAN)
D01475  
Flurbiprofen axetil (JAN)
D01513  
Alminoprofen (JP16/INN)
D01545  
Aceclofenac (JAN/INN)
D01547  
Zaltoprofen (JP16/INN)
D01565  
Indometacin farnesil (JAN)
D01578  
Pranoprofen (JP16/INN)
D01581  
Flufenamic acid (JAN/USAN/INN)
D01582  
Acemetacin (JP16/INN)
D01675  
Felbinac (JP16/USAN/INN)
D01683  
Ozagrel hydrochloride hydrate (JAN)
D01684  
Ozagrel sodium (JP16)
D01709  
Loxoprofen sodium hydrate (JP16)
D01718  
Mofezolac (JAN/INN)
D01765  
Proglumetacin maleate (JAN)
D01767  
Tenoxicam (JAN/USAN/INN)
D01773  
Oxatomide (JAN/USAN/INN)
D01788  
Amfenac sodium hydrate (JAN)
D01811  
Salicylamide (JAN/USP/INN)
D01841  
Felbinac ethyl (JAN)
D01866  
Lornoxicam (JAN/USAN/INN)
D01974  
Tilmacoxib (JAN/USAN/INN)
D02110  
Indometacin sodium (JAN)
D02290  
Flurbiprofen sodium (USP)
D02341  
Meclofenamic acid (USAN/INN)
D02350  
Fenoprofen (USAN/INN)
D02355  
Tolmetin (USAN/INN)
D02709  
Valdecoxib (USAN/INN)
D02755  
Acivicin (USAN/INN)
D03010  
Atreleuton (USAN/INN)
D03080  
Benoxaprofen (USAN/INN)
D03163  
Bromfenac sodium hydrate (JAN)
D03254  
Flufenamate aluminum (JAN)
D03652  
Darbufelone mesylate (USAN)
D03661  
Dazmegrel (USAN/INN)
D03663  
Dazoxiben hydrochloride (USAN)
D03710  
Etoricoxib (USAN/INN)
D03712  
Firocoxib (USAN/INN)
D03714  
Lumiracoxib (USAN/INN)
D03715  
Dexibuprofen (USAN/INN)
D03716  
Parecoxib (USAN/INN)
D03717  
Parecoxib sodium (USAN)
D03718  
Dexibuprofen lysine (USAN)
D03882  
Docebenone (USAN/INN)
D03938  
Ecopladib (USAN/INN)
D03990  
Enazadrem phosphate (USAN)
D04102  
Etofenamate (USAN/INN)
D04151  
Fenleuton (USAN/INN)
D04276  
Furegrelate sodium (USAN)
D04490  
Ibuprofen aluminum (USAN)
D04770  
Lonapalene (USAN)
D04863  
Mavacoxib (USAN)
D05143  
Nepafenac (JAN/USAN/INN)
D05181  
Aspirin aluminum (JP16)
D05319  
Oxyphenbutazone hydrate
D05451  
Phenbutazone sodium glycerate (USAN)
D05502  
Pirmagrel (USAN/INN)
D05511  
Piroxicam betadex (USAN)
D05512  
Piroxicam cinnamate (USAN)
D05513  
Piroxicam olamine (USAN)
D05598  
Pravadoline maleate (USAN)
D05727  
Ridogrel (USAN/INN)
D06600  
Giripladib (USAN)
D06606  
Ibuprofen lysine (USAN)
D06674  
Efipladib (USAN)
D07141  
Indobufen (INN)
D07142  
Triflusal (INN)
D07269  
Dexketoprofen (INN)
D07421  
Aloxiprin (INN)
D07443  
Amfenac (INN)
D07516  
Benzydamine (INN)
D07517  
Benzydamine salicylate
D07541  
Bromfenac (INN)
D07579  
Aspirin calcium salt
D07580  
Aspirin DL-lysine (JAN)
D07581  
Aspirin magnesium salt
D07582  
Aspirin sodium
D07816  
Diclofenac (INN)
D07817  
Diclofenac diethylamine
D07818  
Diclofenac hydroxyethylpyrrolidine
D07819  
Diclofenac calcium
D07888  
Eltenac (INN)
D08058  
Ibuprofen arginine salt
D08059  
Ibuprofen sodium
D08102  
Ketoprofen lysine
D08103  
Ketoprofen sodium
D08104  
Ketorolac (INN)
D08149  
Loxoprofen (INN)
D08162  
Meclofenamate sodium
D08275  
Niflumic acid (INN)
D08324  
Oxyphenbutazone (INN)
D08327  
Ozagrel (INN)
D08363  
Phenylbutazone calcium
D08364  
Phenylbutazone sodium
D08374  
Piketoprofen (INN)
D08375  
Piketoprofen hydrochloride
D08427  
Proglumetacin (INN)
D08657  
Apricoxib (USAN/INN)
D09667  
Setileuton (USAN/INN)
D09760  
Ibuprofen sodium (USAN)
D10017  
Naproxen etemesil (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
8399  
PLA2G10; phospholipase A2, group X [KO:K01047] [EC:3.1.1.4]
26279  
PLA2G2D; phospholipase A2, group IID [KO:K01047] [EC:3.1.1.4]
30814  
PLA2G2E; phospholipase A2, group IIE [KO:K01047] [EC:3.1.1.4]
50487  
PLA2G3; phospholipase A2, group III [KO:K01047] [EC:3.1.1.4]
64600  
PLA2G2F; phospholipase A2, group IIF [KO:K01047] [EC:3.1.1.4]
81579  
PLA2G12A; phospholipase A2, group XIIA [KO:K01047] [EC:3.1.1.4]
84647  
PLA2G12B; phospholipase A2, group XIIB [KO:K01047] [EC:3.1.1.4]
5319  
PLA2G1B; phospholipase A2, group IB (pancreas) [KO:K01047] [EC:3.1.1.4]
5322  
PLA2G5; phospholipase A2, group V [KO:K01047] [EC:3.1.1.4]
5320  
PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid) [KO:K01047] [EC:3.1.1.4]
391013  
PLA2G2C; phospholipase A2, group IIC [KO:K01047] [EC:3.1.1.4]
123745  
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
8398  
PLA2G6; phospholipase A2, group VI (cytosolic, calcium-independent) [KO:K16343] [EC:3.1.1.4]
151056  
PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.5 3.1.1.4]
11145  
PLA2G16; phospholipase A2, group XVI [KO:K16817] [EC:3.1.1.4 3.1.1.32]
5742  
PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [KO:K00509] [EC:1.14.99.1]
5743  
PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [KO:K11987] [EC:1.14.99.1]
9536  
PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
80142  
PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
10728  
PTGES3; prostaglandin E synthase 3 (cytosolic) [KO:K15730] [EC:5.3.99.3]
873  
CBR1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.197 1.1.1.189 1.1.1.184]
874  
CBR3; carbonyl reductase 3 [KO:K00084] [EC:1.1.1.184]
127281  
FAM213B; family with sequence similarity 213, member B [KO:K15717] [EC:1.11.1.20]
6916  
TBXAS1; thromboxane A synthase 1 (platelet) [KO:K01832] [EC:5.3.99.5]
27306  
HPGDS; hematopoietic prostaglandin D synthase [KO:K01830] [EC:5.3.99.2]
5730  
PTGDS; prostaglandin D2 synthase 21kDa (brain) [KO:K01830] [EC:5.3.99.2]
8644  
AKR1C3; aldo-keto reductase family 1, member C3 [KO:K04119] [EC:1.1.1.213 1.1.1.188 1.1.1.64]
5740  
PTGIS; prostaglandin I2 (prostacyclin) synthase [KO:K01831] [EC:5.3.99.4]
240  
ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
4048  
LTA4H; leukotriene A4 hydrolase [KO:K01254] [EC:3.3.2.6]
8529  
CYP4F2; cytochrome P450, family 4, subfamily F, polypeptide 2 [KO:K17726] [EC:1.14.13.194 1.14.13.30]
4051  
CYP4F3; cytochrome P450, family 4, subfamily F, polypeptide 3 [KO:K17726] [EC:1.14.13.194 1.14.13.30]
4056  
LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
2678  
GGT1; gamma-glutamyltransferase 1 [KO:K18592] [EC:3.4.19.14 3.4.19.13 2.3.2.2]
2687  
GGT5; gamma-glutamyltransferase 5 [KO:K18592] [EC:3.4.19.14 3.4.19.13 2.3.2.2]
257202  
GPX6; glutathione peroxidase 6 (olfactory) [KO:K00432] [EC:1.11.1.9]
2882  
GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
2877  
GPX2; glutathione peroxidase 2 (gastrointestinal) [KO:K00432] [EC:1.11.1.9]
2878  
GPX3; glutathione peroxidase 3 (plasma) [KO:K00432] [EC:1.11.1.9]
2876  
GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
2880  
GPX5; glutathione peroxidase 5 (epididymal androgen-related protein) [KO:K00432] [EC:1.11.1.9]
493869  
GPX8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
1571  
CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1 [KO:K07415] [EC:1.14.13.-]
1573  
CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 [KO:K07418] [EC:1.14.14.1]
113612  
CYP2U1; cytochrome P450, family 2, subfamily U, polypeptide 1 [KO:K07422]
1579  
CYP4A11; cytochrome P450, family 4, subfamily A, polypeptide 11 [KO:K17687] [EC:1.14.15.3]
1557  
CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 [KO:K17721] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
11283  
CYP4F8; cytochrome P450, family 4, subfamily F, polypeptide 8 [KO:K17728] [EC:1.14.14.1]
239  
ALOX12; arachidonate 12-lipoxygenase [KO:K00458] [EC:1.13.11.31]
242  
ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
247  
ALOX15B; arachidonate 15-lipoxygenase, type B [KO:K08022] [EC:1.13.11.- 1.13.11.33]
1555  
CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 [KO:K17709] [EC:1.14.13.-]
1558  
CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8 [KO:K17718] [EC:1.14.14.1]
1559  
CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 [KO:K17719] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
2053  
EPHX2; epoxide hydrolase 2, cytoplasmic [KO:K08726] [EC:3.1.3.76 3.3.2.10]
246  
ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
Compound
C00157  
Phosphatidylcholine
C00219  
Arachidonate
C00427  
Prostaglandin H2
C00584  
Prostaglandin E2
C00639  
Prostaglandin F2alpha
C00696  
Prostaglandin D2
C00909  
Leukotriene A4
C01312  
Prostaglandin I2
C02165  
Leukotriene B4
C02166  
Leukotriene C4
C02198  
Thromboxane A2
C03577  
20-Hydroxyleukotriene E4
C04577  
15-OxoETE
C04742  
(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04805  
5(S)-HETE
C04822  
8(R)-HPETE
C04853  
20-OH-Leukotriene B4
C05356  
5(S)-HPETE
C05949  
12-Keto-leukotriene B4
C05950  
20-COOH-Leukotriene B4
C05951  
Leukotriene D4
C05952  
Leukotriene E4
C05953  
Prostaglandin A2
C05954  
Prostaglandin B2
C05955  
Prostaglandin C2
C05956  
Prostaglandin G2
C05957  
Prostaglandin J2
C05958  
delta-12-Prostaglandin J2
C05959  
11-epi-Prostaglandin F2alpha
C05960  
15-Keto-prostaglandin F2alpha
C05961  
6-Keto-prostaglandin F1alpha
C05962  
6-Keto-prostaglandin E1
C05963  
Thromboxane B2
C05964  
11-Dehydro-thromboxane B2
C05965  
12(S)-HPETE
C05966  
15(S)-HPETE
C06314  
Lipoxin A4
C06315  
Lipoxin B4
C06462  
Leukotriene F4
C13809  
9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  
15-Deoxy-delta-12,14-PGJ2
C14732  
5-OxoETE
C14748  
20-HETE
C14749  
19(S)-HETE
C14768  
5,6-EET
C14769  
8,9-EET
C14770  
11,12-EET
C14771  
14,15-EET
C14772  
5,6-DHET
C14773  
8,9-DHET
C14774  
11,12-DHET
C14775  
14,15-DHET
C14776  
8(S)-HETE
C14777  
12(S)-HETE
C14778  
16(R)-HETE
C14779  
9(S)-HETE
C14780  
11(R)-HETE
C14781  
15H-11,12-EETA
C14782  
11,12,15-THETA
C14794  
2,3-Dinor-8-iso prostaglandin F2alpha
C14795  
2,3-Dinor-8-iso prostaglandin F1alpha
C14807  
12-OxoETE
C14808  
Hepoxilin A3
C14809  
Trioxilin A3
C14810  
Hepoxilin B3
C14811  
Trioxilin B3
C14812  
12(R)-HPETE
C14813  
11H-14,15-EETA
C14814  
11,14,15-THETA
C14815  
5,6-Epoxytetraene
C14820  
11(R)-HPETE
C14821  
9(S)-HPETE
C14822  
12(R)-HETE
C14823  
8(S)-HPETE
C14824  
8(R)-HETE
Reference
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
Reference
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
Reference
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
Reference
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
Reference
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
Reference
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
Reference
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
Reference
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
KO pathway
 

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