KEGG   PATHWAY: hsa03060
Entry
hsa03060                    Pathway                                
Name
Protein export - Homo sapiens (human)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
hsa03060  Protein export
hsa03060

Other DBs
GO: 0043952 0043953
Organism
Homo sapiens (human) [GN:hsa]
Gene
5018  OXA1L; OXA1L mitochondrial inner membrane protein [KO:K03217]
6729  SRP54; signal recognition particle 54 [KO:K03106] [EC:3.6.5.4]
29927  SEC61A1; SEC61 translocon subunit alpha 1 [KO:K10956]
55176  SEC61A2; SEC61 translocon subunit alpha 2 [KO:K10956]
10952  SEC61B; SEC61 translocon subunit beta [KO:K09481]
23480  SEC61G; SEC61 translocon subunit gamma [KO:K07342]
7095  SEC62; SEC62 homolog, preprotein translocation factor [KO:K12275]
11231  SEC63; SEC63 homolog, protein translocation regulator [KO:K09540]
3309  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
6726  SRP9; signal recognition particle 9 [KO:K03109]
6727  SRP14; signal recognition particle 14 [KO:K03104]
6731  SRP72; signal recognition particle 72 [KO:K03108]
6730  SRP68; signal recognition particle 68 [KO:K03107]
6728  SRP19; signal recognition particle 19 [KO:K03105]
6734  SRPRA; SRP receptor subunit alpha [KO:K13431]
58477  SRPRB; SRP receptor subunit beta [KO:K12272]
439  GET3; guided entry of tail-anchored proteins factor 3, ATPase [KO:K01551] [EC:7.3.2.7 7.3.-.-]
51608  GET4; guided entry of tail-anchored proteins factor 4 [KO:K23387]
8266  UBL4A; ubiquitin like 4A [KO:K23388]
164153  UBL4B; ubiquitin like 4B [KO:K23388]
7917  BAG6; BAG cochaperone 6 [KO:K23390]
6449  SGTA; small glutamine rich tetratricopeptide repeat co-chaperone alpha [KO:K16365]
7485  GET1; guided entry of tail-anchored proteins factor 1 [KO:K22384]
29100  TMEM208; transmembrane protein 208 [KO:K27164]
28972  SPCS1; signal peptidase complex subunit 1 [KO:K12946] [EC:3.4.-.-]
9789  SPCS2; signal peptidase complex subunit 2 [KO:K12947] [EC:3.4.-.-]
60559  SPCS3; signal peptidase complex subunit 3 [KO:K12948] [EC:3.4.-.-]
90701  SEC11C; SEC11 homolog C, signal peptidase complex subunit [KO:K13280] [EC:3.4.21.89]
23478  SEC11A; SEC11 homolog A, signal peptidase complex subunit [KO:K13280] [EC:3.4.21.89]
196294  IMMP1L; inner mitochondrial membrane peptidase subunit 1 [KO:K09647] [EC:3.4.21.-]
83943  IMMP2L; inner mitochondrial membrane peptidase subunit 2 [KO:K09648] [EC:3.4.21.-]
Reference
PMID:10087917
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
PMID:10652088
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
PMID:10747959
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
PMID:11007775
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
PMID:18046402
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
PMID:17368028
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
PMID:16212506
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
PMID:12475201
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
PMID:10924740
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
PMID:17259602
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   

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Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG GENES (31)   
All databases (32)   

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