KEGG   PATHWAY: hsa03320Help
Entry
hsa03320                    Pathway                                

Name
PPAR signaling pathway - Homo sapiens (human)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
PPAR signaling pathway
hsa03320

All organismsOrtholog table
Disease
H00151  
Cerebrotendinous xanthomatosis
H00154  
Hyperlipoproteinemia, type I
H00157  
Hyperlipoproteinemia, type V
H00407  
Peroxisomal beta-oxidation enzyme deficiency
H00409  
Type II diabetes mellitus
H00420  
Familial partial lipodystrophy (FPL)
H00552  
Glycerol kinase deficiency (GKD)
H00874  
Leukoencephalopathy with dystonia and motor neuropathy
H00930  
Hypoalphalipoproteinemia
H00967  
Adiponectin deficiency
H01108  
CD36 deficiency
H01199  
Hyperalphalipoproteinemia
Drug
D00279  
Clofibrate (JP16/USP/INN)
D00334  
Gemfibrozil (JAN/USP/INN)
D00395  
Troglitazone (JAN/USAN/INN)
D00565  
Fenofibrate (JAN/INN)
D00596  
Rosiglitazone maleate (JAN/USAN)
D00945  
Pioglitazone hydrochloride (JP16/USP)
D01208  
Aluminum clofibrate (JAN/INN)
D01366  
Bezafibrate (JP16/USAN/INN)
D02815  
Alitretinoin (USAN)
D03106  
Bexarotene (USAN/INN)
D03493  
Ciglitazone (USAN/INN)
D03521  
Ciprofibrate (USAN/INN)
D03653  
Darglitazone sodium (USAN)
D03747  
Ibrolipim (USAN/INN)
D03941  
Edaglitazone sodium (USAN)
D05030  
Mifobate (USAN/INN)
D05091  
Muraglitazar (USAN/INN)
D05150  
Netoglitazone (USAN/INN)
D05292  
Oxfenicine (USAN/INN)
D05739  
Rivoglitazone (USAN/INN)
D06102  
Theofibrate (USAN)
D07187  
Etofibrate (INN)
D07724  
Magnesium clofibrate (INN)
D08378  
Pioglitazone (INN)
D08491  
Rosiglitazone (INN)
D08845  
Aleglitazar (USAN)
D08890  
Choline fenofibrate (USAN/INN)
D08949  
Naveglitazar (USAN/INN)
D09350  
Indeglitazar (USAN)
D09579  
Arhalofenate (USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
948  
CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
376497  
SLC27A1; solute carrier family 27 (fatty acid transporter), member 1 [KO:K08745] [EC:6.2.1.-]
10999  
SLC27A4; solute carrier family 27 (fatty acid transporter), member 4 [KO:K08745] [EC:6.2.1.-]
11001  
SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 [KO:K08746] [EC:6.2.1.3 6.2.1.-]
10998  
SLC27A5; solute carrier family 27 (fatty acid transporter), member 5 [KO:K08748] [EC:6.2.1.7]
28965  
SLC27A6; solute carrier family 27 (fatty acid transporter), member 6 [KO:K08749]
2168  
FABP1; fatty acid binding protein 1, liver [KO:K08750]
2169  
FABP2; fatty acid binding protein 2, intestinal [KO:K08751]
2170  
FABP3; fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) [KO:K08752]
2167  
FABP4; fatty acid binding protein 4, adipocyte [KO:K08753]
2171  
FABP5; fatty acid binding protein 5 (psoriasis-associated) [KO:K08754]
2172  
FABP6; fatty acid binding protein 6, ileal [KO:K08755]
2173  
FABP7; fatty acid binding protein 7, brain [KO:K08756]
5465  
PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
6256  
RXRA; retinoid X receptor, alpha [KO:K08524]
6257  
RXRB; retinoid X receptor, beta [KO:K08525]
6258  
RXRG; retinoid X receptor, gamma [KO:K08526]
5467  
PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
5468  
PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
335  
APOA1; apolipoprotein A-I [KO:K08757]
336  
APOA2; apolipoprotein A-II [KO:K08758]
345  
APOC3; apolipoprotein C-III [KO:K08759]
116519  
APOA5; apolipoprotein A-V [KO:K09025]
5360  
PLTP; phospholipid transfer protein [KO:K08761]
9415  
FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.-]
6319  
SCD; stearoyl-CoA desaturase (delta-9-desaturase) [KO:K00507] [EC:1.14.19.1]
79966  
SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
1581  
CYP7A1; cytochrome P450, family 7, subfamily A, polypeptide 1 [KO:K00489] [EC:1.14.13.17]
1582  
CYP8B1; cytochrome P450, family 8, subfamily B, polypeptide 1 [KO:K07431] [EC:1.14.13.96 1.14.13.95]
10062  
NR1H3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]
1593  
CYP27A1; cytochrome P450, family 27, subfamily A, polypeptide 1 [KO:K00488] [EC:1.14.13.15]
1622  
DBI; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) [KO:K08762]
4023  
LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
23305  
ACSL6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
2182  
ACSL4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
2180  
ACSL1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
51703  
ACSL5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
2181  
ACSL3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
23205  
ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
81616  
ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
4973  
OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
1962  
EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
30  
ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
6342  
SCP2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
8310  
ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
51  
ACOX1; acyl-CoA oxidase 1, palmitoyl [KO:K00232] [EC:1.3.3.6]
8309  
ACOX2; acyl-CoA oxidase 2, branched chain [KO:K10214] [EC:1.17.99.3]
1374  
CPT1A; carnitine palmitoyltransferase 1A (liver) [KO:K08765] [EC:2.3.1.21]
1375  
CPT1B; carnitine palmitoyltransferase 1B (muscle) [KO:K08765] [EC:2.3.1.21]
126129  
CPT1C; carnitine palmitoyltransferase 1C [KO:K08765] [EC:2.3.1.21]
1376  
CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
33  
ACADL; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
34  
ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
51129  
ANGPTL4; angiopoietin-like 4 [KO:K08767]
10580  
SORBS1; sorbin and SH3 domain containing 1 [KO:K06086]
5346  
PLIN1; perilipin 1 [KO:K08768]
9370  
ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
4312  
MMP1; matrix metallopeptidase 1 (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
7350  
UCP1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769]
3611  
ILK; integrin-linked kinase [KO:K06272] [EC:2.7.11.1]
5170  
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
7316  
UBC; ubiquitin C [KO:K08770]
5105  
PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
5106  
PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
2712  
GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
2710  
GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
364  
AQP7; aquaporin 7 [KO:K08771]
3158  
HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) [KO:K01641] [EC:2.3.3.10]
4199  
ME1; malic enzyme 1, NADP(+)-dependent, cytosolic [KO:K00029] [EC:1.1.1.40]
Compound
C02165  
Leukotriene B4
C14762  
13(S)-HODE
C14767  
9(S)-HODE
C14776  
8(S)-HETE
C15493  
9-cis-Retinoic acid
Reference
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
Reference
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
Reference
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
Reference
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
Reference
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
Reference
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
Reference
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
Reference
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
KO pathway
 

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