KEGG   PATHWAY: hsa04070Help
Entry
hsa04070                    Pathway                                

Name
Phosphatidylinositol signaling system - Homo sapiens (human)
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Phosphatidylinositol signaling system
hsa04070

All organismsOrtholog table
Disease
H00530  
Joubert syndrome
H00692  
Lowe syndrome
H00694  
Dent disease
H00700  
Centronuclear myopathy
H00865  
Lethal congenital contractural syndrome (LCCS)
H00957  
Fleck corneal dystrophy (FCD)
H01195  
VACTERL/VATER association
H01307  
Nonsyndromic congenital nail disorder (NDNC)
Organism
Homo sapiens (human) [GN:hsa]
Gene
5297  
PI4KA; phosphatidylinositol 4-kinase, catalytic, alpha [KO:K00888] [EC:2.7.1.67]
5298  
PI4KB; phosphatidylinositol 4-kinase, catalytic, beta [KO:K00888] [EC:2.7.1.67]
55361  
PI4K2A; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
55300  
PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
23396  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
8394  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
8395  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
8525  
DGKZ; diacylglycerol kinase, zeta [KO:K00901] [EC:2.7.1.107]
8527  
DGKD; diacylglycerol kinase, delta 130kDa [KO:K00901] [EC:2.7.1.107]
9162  
DGKI; diacylglycerol kinase, iota [KO:K00901] [EC:2.7.1.107]
1606  
DGKA; diacylglycerol kinase, alpha 80kDa [KO:K00901] [EC:2.7.1.107]
8526  
DGKE; diacylglycerol kinase, epsilon 64kDa [KO:K00901] [EC:2.7.1.107]
1607  
DGKB; diacylglycerol kinase, beta 90kDa [KO:K00901] [EC:2.7.1.107]
160851  
DGKH; diacylglycerol kinase, eta [KO:K00901] [EC:2.7.1.107]
1608  
DGKG; diacylglycerol kinase, gamma 90kDa [KO:K00901] [EC:2.7.1.107]
1609  
DGKQ; diacylglycerol kinase, theta 110kDa [KO:K00901] [EC:2.7.1.107]
3707  
ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706  
ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271  
ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
3705  
ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.134 2.7.1.159]
5289  
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
79837  
PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
5305  
PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
8396  
PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
200576  
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5288  
PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5286  
PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287  
PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
64768  
IPPK; inositol 1,3,4,5,6-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
1040  
CDS1; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [KO:K00981] [EC:2.7.7.41]
8760  
CDS2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [KO:K00981] [EC:2.7.7.41]
10423  
CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
3613  
IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
3612  
IMPA1; inositol(myo)-1(or 4)-monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
54928  
IMPAD1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7 3.1.3.25]
8867  
SYNJ1; synaptojanin 1 [KO:K01099] [EC:3.1.3.36]
8871  
SYNJ2; synaptojanin 2 [KO:K01099] [EC:3.1.3.36]
4952  
OCRL; oculocerebrorenal syndrome of Lowe [KO:K01099] [EC:3.1.3.36]
56623  
INPP5E; inositol polyphosphate-5-phosphatase, 72 kDa [KO:K01099] [EC:3.1.3.36]
3633  
INPP5B; inositol polyphosphate-5-phosphatase, 75kDa [KO:K01099] [EC:3.1.3.36]
5728  
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
51763  
INPP5K; inositol polyphosphate-5-phosphatase K [KO:K01106] [EC:3.1.3.56]
27124  
INPP5J; inositol polyphosphate-5-phosphatase J [KO:K01106] [EC:3.1.3.56]
3632  
INPP5A; inositol polyphosphate-5-phosphatase, 40kDa [KO:K01106] [EC:3.1.3.56]
3628  
INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
4534  
MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.64]
3631  
INPP4A; inositol polyphosphate-4-phosphatase, type I, 107kDa [KO:K01109] [EC:3.1.3.66]
8821  
INPP4B; inositol polyphosphate-4-phosphatase, type II, 105kDa [KO:K01109] [EC:3.1.3.66]
23236  
PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
5333  
PLCD1; phospholipase C, delta 1 [KO:K05857] [EC:3.1.4.11]
113026  
PLCD3; phospholipase C, delta 3 [KO:K05857] [EC:3.1.4.11]
84812  
PLCD4; phospholipase C, delta 4 [KO:K05857] [EC:3.1.4.11]
51196  
PLCE1; phospholipase C, epsilon 1 [KO:K05860] [EC:3.1.4.11]
5335  
PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  
PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
89869  
PLCZ1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
3708  
ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
3709  
ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
3710  
ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
5295  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5578  
PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
3635  
INPP5D; inositol polyphosphate-5-phosphatase, 145kDa [KO:K03084] [EC:3.1.3.86]
3636  
INPPL1; inositol polyphosphate phosphatase-like 1 [KO:K15909] [EC:3.1.3.86]
810  
CALML3; calmodulin-like 3 [KO:K02183]
805  
CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808  
CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801  
CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688  
CALML6; calmodulin-like 6 [KO:K02183]
51806  
CALML5; calmodulin-like 5 [KO:K02183]
Compound
C00076  
Calcium cation
C00137  
myo-Inositol
C00165  
Diacylglycerol
C00269  
CDP-diacylglycerol
C00416  
Phosphatidate
C00641  
1,2-Diacyl-sn-glycerol
C01177  
Inositol 1-phosphate
C01194  
1-Phosphatidyl-D-myo-inositol
C01204  
Phytic acid
C01220  
1D-myo-Inositol 1,4-bisphosphate
C01243  
1D-myo-Inositol 1,3,4-trisphosphate
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01272  
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  
1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  
1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  
myo-Inositol 4-phosphate
C04006  
1D-myo-Inositol 3-phosphate
C04062  
D-myo-Inositol 1,3-bisphosphate
C04063  
D-myo-Inositol 3,4-bisphosphate
C04477  
1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11174  
1-Diphosinositol pentakisphosphate
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11556  
1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  
1-Phosphatidyl-1D-myo-inositol 5-phosphate
KO pathway
 

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