KEGG PATHWAY: hsa04070

PATHWAY: hsa04070

Entry

hsa04070 Pathway

Name

Phosphatidylinositol signaling system - Homo sapiens (human)

Class

Environmental Information Processing; Signal transduction

Pathway map

hsa04070

Phosphatidylinositol signaling system

Disease

H00530	Joubert syndrome
H00692	Lowe syndrome
H00694	Dent disease
H00700	Centronuclear myopathy
H00865	Lethal congenital contractural syndrome (LCCS)
H00957	Fleck corneal dystrophy (FCD)
H01195	VACTERL/VATER association
H01307	Nonsyndromic congenital nail disorder (NDNC)

Organism

Homo sapiens (human) [GN:hsa]

Gene

5297	PI4KA; phosphatidylinositol 4-kinase, catalytic, alpha [KO:K00888] [EC:2.7.1.67]
5298	PI4KB; phosphatidylinositol 4-kinase, catalytic, beta [KO:K00888] [EC:2.7.1.67]
55361	PI4K2A; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
55300	PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
23396	PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
8394	PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
8395	PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
8525	DGKZ; diacylglycerol kinase, zeta [KO:K00901] [EC:2.7.1.107]
8527	DGKD; diacylglycerol kinase, delta 130kDa [KO:K00901] [EC:2.7.1.107]
9162	DGKI; diacylglycerol kinase, iota [KO:K00901] [EC:2.7.1.107]
1606	DGKA; diacylglycerol kinase, alpha 80kDa [KO:K00901] [EC:2.7.1.107]
8526	DGKE; diacylglycerol kinase, epsilon 64kDa [KO:K00901] [EC:2.7.1.107]
1607	DGKB; diacylglycerol kinase, beta 90kDa [KO:K00901] [EC:2.7.1.107]
160851	DGKH; diacylglycerol kinase, eta [KO:K00901] [EC:2.7.1.107]
1608	DGKG; diacylglycerol kinase, gamma 90kDa [KO:K00901] [EC:2.7.1.107]
1609	DGKQ; diacylglycerol kinase, theta 110kDa [KO:K00901] [EC:2.7.1.107]
3707	ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706	ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271	ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
3705	ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.134 2.7.1.159]
5289	PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
79837	PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
5305	PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
8396	PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
200576	PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5288	PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5286	PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287	PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
64768	IPPK; inositol 1,3,4,5,6-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
1040	CDS1; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [KO:K00981] [EC:2.7.7.41]
8760	CDS2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [KO:K00981] [EC:2.7.7.41]
10423	CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
3613	IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
3612	IMPA1; inositol(myo)-1(or 4)-monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
54928	IMPAD1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7 3.1.3.25]
8867	SYNJ1; synaptojanin 1 [KO:K01099] [EC:3.1.3.36]
8871	SYNJ2; synaptojanin 2 [KO:K01099] [EC:3.1.3.36]
4952	OCRL; oculocerebrorenal syndrome of Lowe [KO:K01099] [EC:3.1.3.36]
56623	INPP5E; inositol polyphosphate-5-phosphatase, 72 kDa [KO:K01099] [EC:3.1.3.36]
3633	INPP5B; inositol polyphosphate-5-phosphatase, 75kDa [KO:K01099] [EC:3.1.3.36]
5728	PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
51763	INPP5K; inositol polyphosphate-5-phosphatase K [KO:K01106] [EC:3.1.3.56]
27124	INPP5J; inositol polyphosphate-5-phosphatase J [KO:K01106] [EC:3.1.3.56]
3632	INPP5A; inositol polyphosphate-5-phosphatase, 40kDa [KO:K01106] [EC:3.1.3.56]
3628	INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
4534	MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.64]
3631	INPP4A; inositol polyphosphate-4-phosphatase, type I, 107kDa [KO:K01109] [EC:3.1.3.66]
8821	INPP4B; inositol polyphosphate-4-phosphatase, type II, 105kDa [KO:K01109] [EC:3.1.3.66]
23236	PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330	PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331	PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332	PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
5333	PLCD1; phospholipase C, delta 1 [KO:K05857] [EC:3.1.4.11]
113026	PLCD3; phospholipase C, delta 3 [KO:K05857] [EC:3.1.4.11]
84812	PLCD4; phospholipase C, delta 4 [KO:K05857] [EC:3.1.4.11]
51196	PLCE1; phospholipase C, epsilon 1 [KO:K05860] [EC:3.1.4.11]
5335	PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
5336	PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
89869	PLCZ1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
3708	ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
3709	ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
3710	ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
5295	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5578	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
3635	INPP5D; inositol polyphosphate-5-phosphatase, 145kDa [KO:K03084] [EC:3.1.3.86]
3636	INPPL1; inositol polyphosphate phosphatase-like 1 [KO:K15909] [EC:3.1.3.86]
810	CALML3; calmodulin-like 3 [KO:K02183]
805	CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808	CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801	CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688	CALML6; calmodulin-like 6 [KO:K02183]
51806	CALML5; calmodulin-like 5 [KO:K02183]

Compound

C00076	Calcium cation
C00137	myo-Inositol
C00165	Diacylglycerol
C00269	CDP-diacylglycerol
C00416	Phosphatidate
C00641	1,2-Diacyl-sn-glycerol
C01177	Inositol 1-phosphate
C01194	1-Phosphatidyl-D-myo-inositol
C01204	Phytic acid
C01220	1D-myo-Inositol 1,4-bisphosphate
C01243	1D-myo-Inositol 1,3,4-trisphosphate
C01245	D-myo-Inositol 1,4,5-trisphosphate
C01272	1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277	1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284	1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546	myo-Inositol 4-phosphate
C04006	1D-myo-Inositol 3-phosphate
C04062	D-myo-Inositol 1,3-bisphosphate
C04063	D-myo-Inositol 3,4-bisphosphate
C04477	1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637	1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate
C11174	1-Diphosinositol pentakisphosphate
C11554	1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11556	1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557	1-Phosphatidyl-1D-myo-inositol 5-phosphate

KO pathway

ko04070

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (1)   
   BioSystems (1)   
Disease (8)   
   KEGG DISEASE (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (81)   
   KEGG GENES (81)   
All databases (92)   

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