KEGG   PATHWAY: hsa04140Help
Entry
hsa04140                    Pathway                                

Name
Regulation of autophagy - Homo sapiens (human)
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Regulation of autophagy
hsa04140

All organismsOrtholog table
Drug
D00595  
Buformin (USAN/INN)
D00944  
Metformin hydrochloride (JP16/USP)
D02206  
Buformin hydrochloride (JP16)
D03647  
Dapiclermin (USAN/INN)
D04966  
Metformin (USAN/INN)
D08351  
Phenformin (BAN)
D08352  
Phenformin hydrochloride
D09662  
Rontalizumab (USAN/INN)
D09668  
Sifalimumab (USAN/INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
3630  
INS; insulin [KO:K04526]
5562  
PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.11]
5563  
PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.11]
3439  
IFNA1; interferon, alpha 1 [KO:K05414]
3440  
IFNA2; interferon, alpha 2 [KO:K05414]
3441  
IFNA4; interferon, alpha 4 [KO:K05414]
3442  
IFNA5; interferon, alpha 5 [KO:K05414]
3443  
IFNA6; interferon, alpha 6 [KO:K05414]
3444  
IFNA7; interferon, alpha 7 [KO:K05414]
3445  
IFNA8; interferon, alpha 8 [KO:K05414]
3446  
IFNA10; interferon, alpha 10 [KO:K05414]
3447  
IFNA13; interferon, alpha 13 [KO:K05414]
3448  
IFNA14; interferon, alpha 14 [KO:K05414]
3449  
IFNA16; interferon, alpha 16 [KO:K05414]
3451  
IFNA17; interferon, alpha 17 [KO:K05414]
3452  
IFNA21; interferon, alpha 21 [KO:K05414]
3458  
IFNG; interferon, gamma [KO:K04687]
25989  
ULK3; unc-51 like kinase 3 [KO:K08269] [EC:2.7.11.1]
8408  
ULK1; unc-51 like autophagy activating kinase 1 [KO:K08269] [EC:2.7.11.1]
9706  
ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
9776  
ATG13; autophagy related 13 [KO:K08331]
30849  
PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
8678  
BECN1; beclin 1, autophagy related [KO:K08334]
22863  
ATG14; autophagy related 14 [KO:K17889]
5289  
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
9140  
ATG12; autophagy related 12 [KO:K08336]
10533  
ATG7; autophagy related 7 [KO:K08337]
83734  
ATG10; autophagy related 10 [KO:K17888] [EC:6.3.2.19]
9474  
ATG5; autophagy related 5 [KO:K08339]
55054  
ATG16L1; autophagy related 16-like 1 (S. cerevisiae) [KO:K17890]
89849  
ATG16L2; autophagy related 16-like 2 (S. cerevisiae) [KO:K17890]
11337  
GABARAP; GABA(A) receptor-associated protein [KO:K08341]
23710  
GABARAPL1; GABA(A) receptor-associated protein like 1 [KO:K08341]
11345  
GABARAPL2; GABA(A) receptor-associated protein-like 2 [KO:K08341]
115201  
ATG4A; autophagy related 4A, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
23192  
ATG4B; autophagy related 4B, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
84938  
ATG4C; autophagy related 4C, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
84971  
ATG4D; autophagy related 4D, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
64422  
ATG3; autophagy related 3 [KO:K08343] [EC:6.3.2.19]
Compound
C00350  
Phosphatidylethanolamine
C00913  
3-Methyladenine
C01194  
1-Phosphatidyl-D-myo-inositol
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C15181  
Wortmannin
Reference
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
Reference
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
Reference
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
Reference
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
KO pathway
 

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