KEGG   PATHWAY: hsa04612Help
Entry
hsa04612                    Pathway                                

Name
Antigen processing and presentation - Homo sapiens (human)
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Antigen processing and presentation
hsa04612

All organismsOrtholog table
Disease
H00344  
Leprosy
H00425  
Lysosomal cysteine protease deficiencies
H00932  
Tropical calcific pancreatitis
H00984  
Bare lymphocyte syndrome (BLS) type1
H00985  
Bare lymphocyte syndrome (BLS) type2
H01132  
Aplastic anemia (AA)
H01303  
Hypercatabolic hypoproteinemia
Drug
D00742  
Etanercept (genetical recombination) (JAN)
D02597  
Adalimumab (genetical recombination) (JAN)
D02598  
Infliximab (genetical recombination) (JAN)
D02967  
Apolizumab (USAN/INN)
D03441  
Certolizumab pegol (genetical recombination) (JAN)
D07436  
Afelimomab (INN)
D08944  
Milatuzumab (USAN)
Other DBs
Organism
Homo sapiens (human) [GN:hsa]
Gene
3458  
IFNG; interferon, gamma [KO:K04687]
7124  
TNF; tumor necrosis factor [KO:K03156]
5720  
PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [KO:K06696]
5721  
PSME2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [KO:K06697]
10197  
PSME3; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma [KO:K06698]
3312  
HSPA8; heat shock 70kDa protein 8 [KO:K03283]
3303  
HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
3306  
HSPA2; heat shock 70kDa protein 2 [KO:K03283]
3305  
HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
3304  
HSPA1B; heat shock 70kDa protein 1B [KO:K03283]
3310  
HSPA6; heat shock 70kDa protein 6 (HSP70B') [KO:K03283]
3308  
HSPA4; heat shock 70kDa protein 4 [KO:K09489]
3320  
HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 [KO:K04079]
3326  
HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 [KO:K04079]
3105  
HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  
HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  
HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  
HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  
HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  
HLA-E; major histocompatibility complex, class I, E [KO:K06751]
821  
CANX; calnexin [KO:K08054]
567  
B2M; beta-2-microglobulin [KO:K08055]
2923  
PDIA3; protein disulfide isomerase family A, member 3 [KO:K08056] [EC:5.3.4.1]
811  
CALR; calreticulin [KO:K08057]
6892  
TAPBP; TAP binding protein (tapasin) [KO:K08058]
6890  
TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05653]
6891  
TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
925  
CD8A; CD8a molecule [KO:K06458]
926  
CD8B; CD8b molecule [KO:K06459]
3812  
KIR3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 [KO:K07980]
3811  
KIR3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 [KO:K07980]
115653  
KIR3DL3; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 [KO:K07980]
3803  
KIR2DL2; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 [KO:K07981]
3802  
KIR2DL1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 [KO:K07981]
3804  
KIR2DL3; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 [KO:K07981]
3805  
KIR2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 [KO:K07981]
57292  
KIR2DL5A; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A [KO:K07981]
killer cell immunoglobulin-like receptor 2DL4-like; K07981 killer cell immunoglobulin-like receptor 2DL [KO:K07981]
3821  
KLRC1; killer cell lectin-like receptor subfamily C, member 1 [KO:K06541]
3822  
KLRC2; killer cell lectin-like receptor subfamily C, member 2 [KO:K06541]
3823  
KLRC3; killer cell lectin-like receptor subfamily C, member 3 [KO:K06541]
8302  
KLRC4; killer cell lectin-like receptor subfamily C, member 4 [KO:K06541]
3824  
KLRD1; killer cell lectin-like receptor subfamily D, member 1 [KO:K06516]
3806  
KIR2DS1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 [KO:K07982]
3808  
KIR2DS3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 [KO:K07982]
3809  
KIR2DS4; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 [KO:K07982]
3810  
KIR2DS5; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 [KO:K07982]
KIR2DS2; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 [KO:K07982]
10437  
IFI30; interferon, gamma-inducible protein 30 [KO:K08059]
5641  
LGMN; legumain [KO:K01369] [EC:3.4.22.34]
1508  
CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
3108  
HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
972  
CD74; CD74 molecule, major histocompatibility complex, class II invariant chain [KO:K06505]
1514  
CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
1520  
CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
920  
CD4; CD4 molecule [KO:K06454]
4261  
CIITA; class II, major histocompatibility complex, transactivator [KO:K08060]
5993  
RFX5; regulatory factor X, 5 (influences HLA class II expression) [KO:K08061]
8625  
RFXANK; regulatory factor X-associated ankyrin-containing protein [KO:K08062]
5994  
RFXAP; regulatory factor X-associated protein [KO:K08063]
1385  
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
4800  
NFYA; nuclear transcription factor Y, alpha [KO:K08064]
4801  
NFYB; nuclear transcription factor Y, beta [KO:K08065]
4802  
NFYC; nuclear transcription factor Y, gamma [KO:K08066]
3309  
HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [KO:K09490]
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
KO pathway
 

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