KEGG   PATHWAY: hsa04614Help
Entry
hsa04614                    Pathway                                

Name
Renin-angiotensin system - Homo sapiens (human)
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Renin-angiotensin system
hsa04614

All organismsOrtholog table
Disease
H00541  
Uromodulin-associated kidney diseases
H00575  
Renal tubular dysgenesis
Drug
D00150  
Angiotensin II (INN)
D00251  
Captopril (JP16/USP/INN)
D00357  
Losartan potassium (JP16/USAN)
D00362  
Lisinopril hydrate (JP16)
D00383  
Trandolapril (JAN/INN)
D00400  
Valsartan (JP16/USAN/INN)
D00421  
Ramipril (USP/INN)
D00459  
Quinapril hydrochloride (JP16/USP)
D00522  
Candesartan (USAN/INN)
D00523  
Irbesartan (JAN/USAN/INN)
D00620  
Benazepril hydrochloride (JAN/USAN)
D00621  
Enalapril maleate (JP16/USP)
D00622  
Fosinopril sodium (USAN)
D00623  
Moexipril hydrochloride (USAN)
D00624  
Perindopril erbumine (JAN/USAN)
D00626  
Candesartan cilexetil (JP16/USAN)
D00627  
Telmisartan (JP16/USAN/INN)
D01069  
Cilazapril hydrate (JP16)
D01070  
Candoxatril (JAN/USAN/INN)
D01119  
Temocapril hydrochloride (JP16/USAN)
D01204  
Olmesartan medoxomil (JP16/USAN)
D01549  
Imidapril hydrochloride (JP16)
D01667  
Delapril hydrochloride (JAN/USAN)
D01900  
Alacepril (JP16/INN)
D01922  
Pratosartan (JAN/INN)
D02014  
Angiotensin II (human type) (JAN)
D02082  
Eprosartan mesylate (USAN)
D02939  
Angiotensin amide (USAN)
D03077  
Benazeprilat (USAN/INN)
D03208  
Aliskiren (USAN/INN)
D03349  
Candoxatrilat (USAN/INN)
D03440  
Ceronapril (USAN/INN)
D03738  
Enalkiren (USAN/INN)
D03741  
Ditekiren (USAN)
D03743  
Terlakiren (USAN/INN)
D03745  
Zankiren hydrochloride (USAN)
D03752  
Quinapril (USP/INN)
D03753  
Perindopril (USAN/INN)
D03756  
Indolapril hydrochloride (USAN)
D03758  
Libenzapril (USAN/INN)
D03760  
Pentopril (USAN/INN)
D03763  
Pivopril (USAN/INN)
D03765  
Spirapril hydrochloride (USAN)
D03767  
Zofenopril calcium (USAN)
D03769  
Enalaprilat (USP)
D03772  
Fosinoprilat (USAN/INN)
D03773  
Quinaprilat (USAN/INN)
D03775  
Spiraprilat (USAN/INN)
D03776  
Zofenoprilat arginine (USAN)
D03929  
Ecadotril (USAN/INN)
D04040  
Eprosartan (USAN/INN)
D04126  
Saralasin acetate (USAN)
D04243  
Forasartan (USAN/INN)
D05246  
Olmesartan (USAN/INN)
D06076  
Teprotide (USAN/INN)
D06412  
Aliskiren fumarate (JAN/USAN)
D07499  
Benazepril (INN)
D07699  
Cilazapril (INN)
D07781  
Delapril  (INN)
D07892  
Enalapril (INN)
D07992  
Fosinopril (INN)
D08067  
Azilsartan medoxomil (USAN)
D08068  
Imidapril (INN)
D08131  
Lisinopril (INN)
D08146  
Losartan (INN)
D08225  
Moexipril (INN)
D08529  
Spirapril (INN)
D08566  
Temocapril (INN)
D08688  
Zofenopril (INN)
D08864  
Azilsartan (JAN/USAN/INN)
D08865  
Azilsartan kamedoxomil (USAN)
D09038  
Remikiren (INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
183  
AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [KO:K09821]
5972  
REN; renin [KO:K01380] [EC:3.4.23.15]
1636  
ACE; angiotensin I converting enzyme [KO:K01283] [EC:3.4.15.1]
59272  
ACE2; angiotensin I converting enzyme 2 [KO:K09708] [EC:3.4.17.23]
1215  
CMA1; chymase 1, mast cell [KO:K01329] [EC:3.4.21.39]
1511  
CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
2028  
ENPEP; glutamyl aminopeptidase (aminopeptidase A) [KO:K11141] [EC:3.4.11.7]
290  
ANPEP; alanyl (membrane) aminopeptidase [KO:K11140] [EC:3.4.11.2]
5476  
CTSA; cathepsin A [KO:K13289] [EC:3.4.16.5]
1359  
CPA3; carboxypeptidase A3 (mast cell) [KO:K08780] [EC:3.4.17.1]
4311  
MME; membrane metallo-endopeptidase [KO:K01389] [EC:3.4.24.11]
7064  
THOP1; thimet oligopeptidase 1 [KO:K01392] [EC:3.4.24.15]
57486  
NLN; neurolysin (metallopeptidase M3 family) [KO:K01393] [EC:3.4.24.16]
4142  
MAS1; MAS1 oncogene [KO:K04303]
185  
AGTR1; angiotensin II receptor, type 1 [KO:K04166]
186  
AGTR2; angiotensin II receptor, type 2 [KO:K04167]
4012  
LNPEP; leucyl/cystinyl aminopeptidase [KO:K01257] [EC:3.4.11.3]
Compound
C00873  
Angiotensin I
C02135  
Angiotensin II
C15848  
Angiotensin III
C15849  
Angiotensin IV
C15850  
Angiotensin (1-7)
C15851  
Angiotensin (1-9)
C15852  
Angiotensin (1-5)
Reference
  Authors
Kramkowski K, Mogielnicki A, Buczko W.
  Title
The physiological significance of the alternative pathways of angiotensin II production.
  Journal
J Physiol Pharmacol 57:529-39 (2006)
Reference
  Authors
Danilczyk U, Eriksson U, Oudit GY, Penninger JM.
  Title
Physiological roles of angiotensin-converting enzyme 2.
  Journal
Cell Mol Life Sci 61:2714-9 (2004)
Reference
  Authors
Warner FJ, Smith AI, Hooper NM, Turner AJ.
  Title
Angiotensin-converting enzyme-2: a molecular and cellular perspective.
  Journal
Cell Mol Life Sci 61:2704-13 (2004)
Reference
  Authors
Kurdi M, De Mello WC, Booz GW.
  Title
Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components.
  Journal
Int J Biochem Cell Biol 37:1357-67 (2005)
Reference
  Authors
Burrell LM, Johnston CI, Tikellis C, Cooper ME.
  Title
ACE2, a new regulator of the renin-angiotensin system.
  Journal
Trends Endocrinol Metab 15:166-9 (2004)
Reference
  Authors
von Bohlen und Halbach O, Albrecht D.
  Title
The CNS renin-angiotensin system.
  Journal
Cell Tissue Res 326:599-616 (2006)
Reference
  Authors
Schmaier AH
  Title
The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction.
  Journal
Am J Physiol Regul Integr Comp Physiol 285:R1-13 (2003)
Reference
  Authors
Eriksson U, Danilczyk U, Penninger JM.
  Title
Just the beginning: novel functions for angiotensin-converting enzymes.
  Journal
Curr Biol 12:R745-52 (2002)
Reference
  Authors
Dielis AW, Smid M, Spronk HM, Hamulyak K, Kroon AA, ten Cate H, de Leeuw PW.
  Title
The prothrombotic paradox of hypertension: role of the renin-angiotensin and kallikrein-kinin systems.
  Journal
Hypertension 46:1236-42 (2005)
Reference
  Authors
Kuba K, Imai Y, Penninger JM.
  Title
Angiotensin-converting enzyme 2 in lung diseases.
  Journal
Curr Opin Pharmacol 6:271-6 (2006)
Reference
  Authors
Erdos EG, Jackman HL, Brovkovych V, Tan F, Deddish PA.
  Title
Products of angiotensin I hydrolysis by human cardiac enzymes potentiate bradykinin.
  Journal
J Mol Cell Cardiol 34:1569-76 (2002)
Reference
  Authors
Shrimpton CN, Smith AI, Lew RA.
  Title
Soluble metalloendopeptidases and neuroendocrine signaling.
  Journal
Endocr Rev 23:647-64 (2002)
Reference
  Authors
Jackman HL, Massad MG, Sekosan M, Tan F, Brovkovych V, Marcic BM, Erdos EG.
  Title
Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A.
  Journal
Hypertension 39:976-81 (2002)
Reference
  Authors
Lundequist A, Tchougounova E, Abrink M, Pejler G.
  Title
Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II.
  Journal
J Biol Chem 279:32339-44 (2004)
Reference
  Authors
Kehoe PG, Wilcock GK.
  Title
Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?
  Journal
Lancet Neurol 6:373-8 (2007)
KO pathway
 

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