KEGG   PATHWAY: hsa04970Help
Entry
hsa04970                    Pathway                                

Name
Salivary secretion - Homo sapiens (human)
Description
Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP.
Class
Organismal Systems; Digestive system
BRITE hierarchy
Pathway map
Salivary secretion
hsa04970

All organismsOrtholog table
Disease
H00845  
Familial amyloidosis
Drug
D00076  
Noradrenaline (JP16)
D00095  
Adrenaline (JP16)
D00113  
Atropine (USP)
D00124  
Ephedrine (USP)
D00138  
Scopolamine (INN)
D00147  
Hyoscyamine (USP)
D00232  
Methyloctatropine bromide (JAN)
D00235  
Atenolol (JP16/USP/INN)
D00255  
Carvedilol (JAN/USAN/INN)
D00283  
Clozapine (JAN/USP/INN)
D00378  
Timolol (USAN)
D00397  
Tropicamide (JP16/USP/INN)
D00426  
Risperidone (JP16/USAN/INN)
D00432  
Nadolol (JP16/USP/INN)
D00454  
Olanzapine (JAN/USAN/INN)
D00458  
Quetiapine fumarate (JP16/USAN)
D00465  
Oxybutynin (USAN/INN)
D00481  
Propantheline bromide (JP16/USP/INN)
D00483  
Propranolol hydrochloride (JP16/USP)
D00485  
Pseudoephedrine hydrochloride (USP)
D00507  
Phenoxybenzamine hydrochloride (USP)
D00509  
Phentolamine mesilate (JAN/INN)
D00511  
Phenylephrine hydrochloride (JP16/USP)
D00513  
Pindolol (JP16/USP/INN)
D00524  
Carbachol (JAN/USP/INN)
D00525  
Pilocarpine (JAN/USP)
D00540  
Glycopyrronium bromide (JAN/INN)
D00560  
Pimozide (JP16/USP/INN)
D00597  
Acebutolol hydrochloride (JP16/USP)
D00598  
Betaxolol hydrochloride (JP16/USP)
D00599  
Carteolol hydrochloride (JP16/USP)
D00600  
Labetalol hydrochloride (JP16/USP)
D00601  
Metoprolol tartrate (JP16/USP)
D00602  
Penbutolol sulfate (JP16/USP)
D00603  
Timolol maleate (JP16/USP)
D00607  
Guanadrel sulfate (USP)
D00608  
Doxazosin mesilate (JP16)
D00609  
Prazosin hydrochloride (JP16/USP)
D00610  
Terazosin hydrochloride hydrate (JAN)
D00632  
Dobutamine hydrochloride (JP16/USP)
D00634  
Bisoprolol fumarate (JP16/USP)
D00635  
Metoprolol succinate (USP)
D00644  
Esmolol hydrochloride (JAN/USAN)
D00646  
Tolterodine (USAN/INN)
D00661  
Cevimeline hydrochloride hydrate (JAN)
D00679  
Ergotamine tartrate (JP16/USP)
D00680  
Methylergometrine maleate (JP16)
D00683  
Salbutamol sulfate (JP16)
D00684  
Bitolterol mesilate (JAN)
D00685  
Orciprenaline sulfate (JP16)
D00686  
Pirbuterol acetate (USAN)
D00687  
Salmeterol xinafoate (JAN/USAN)
D00688  
Terbutaline sulfate (JP16/USP)
D00715  
Hyoscine methobromide (INN)
D00719  
Hyoscyamine sulfate (USP)
D00720  
Mepenzolate bromide (JP16/INN)
D00721  
Methanthelinium bromide (INN)
D00722  
Oxybutynin hydrochloride (JAN)
D00723  
Tridihexethyl chloride (BAN)
D00743  
Naphazoline hydrochloride (JP16/USP)
D00756  
Tetrahydrozoline nitrate (JAN)
D00774  
Orphenadrine citrate (USP)
D00778  
Benztropine mesilate (JAN)
D00779  
Biperiden (JAN/USP/INN)
D00782  
Procyclidine hydrochloride (USP)
D00787  
Trihexyphenidyl hydrochloride (JP16/USP)
D00789  
Chlorpromazine hydrochloride (JP16/USP)
D00996  
Epinephrine hydrochloride (JAN)
D00997  
Tolazoline hydrochloride (JAN/USP)
D00999  
Acetylcholine chloride (JP16/USP/INN)
D01000  
Bethanechol chloride (JP16/USP)
D01002  
Cyclopentolate hydrochloride (JP16/USP)
D01003  
Hexocyclium metilsulfate (INN)
D01004  
Homatropine hydrobromide (JP16/USP)
D01005  
Isopropamide iodide (JAN/USP/INN)
D01006  
Oxyphencyclimine hydrochloride (JAN)
D01007  
Propiverine hydrochloride (JP16)
D01017  
Dipivefrin hydrochloride (JAN/USP)
D01019  
Metaraminol bitartrate (JAN/USP)
D01020  
Methoxamine hydrochloride (JAN)
D01021  
Naphazoline nitrate (JP16)
D01022  
Oxymetazoline hydrochloride (JAN/USP)
D01023  
Tetrahydrozoline hydrochloride (JAN/USP)
D01024  
Tamsulosin hydrochloride (JP16/USAN)
D01025  
Levobunolol hydrochloride (JAN/USP)
D01077  
Atropine methonitrate (JAN/INN)
D01103  
Trospium chloride (JAN/USAN/INN)
D01118  
Profenamine hydrochloride (JAN)
D01148  
Tolterodine tartrate (JAN/USAN)
D01165  
Piperidolate hydrochloride (JAN)
D01175  
Carpronium chloride (JAN/INN)
D01182  
Alprenolol hydrochloride (JP16/USAN)
D01201  
Tiemonium iodide (JAN/INN)
D01231  
Piroheptine hydrochloride (JAN)
D01263  
Ritodrine hydrochloride (JP16/USP)
D01269  
Solifenacin succinate (JAN/USAN/INN)
D01307  
Midodrine hydrochloride (JAN/USAN)
D01315  
Methylbenactyzium bromide (JP16/INN)
D01323  
Azosemide (JAN/USAN/INN)
D01333  
Urapidil (JP16/INN)
D01347  
Tramazoline hydrochloride (JAN/USAN)
D01349  
Pirbuterol hydrochloride (JAN/USAN)
D01359  
Etomidoline (JAN/INN)
D01360  
Clenbuterol hydrochloride (JAN/USP)
D01362  
Tulobuterol hydrochloride (JP16)
D01369  
Bevantolol hydrochloride (JAN/USAN)
D01373  
Formoterol fumarate (USAN)
D01377  
Prifinium bromide (JAN/INN)
D01386  
Ephedrine hydrochloride (JP16/USP)
D01390  
dl-Isoprenaline hydrochloride (JAN)
D01405  
Norfenefrine hydrochloride (JAN)
D01428  
Fenoterol hydrobromide (JAN)
D01444  
Bunitrolol hydrochloride (JAN)
D01451  
Scopolamine butylbromide (JP16)
D01454  
Bupranolol hydrochloride (JP16)
D01463  
Diponium bromide (JAN/INN)
D01469  
Amosulalol hydrochloride (JP16)
D01471  
Esatenolol (JAN/INN)
D01491  
Butropium bromide (JP16/INN)
D01500  
Trimebutine maleate (JP16)
D01504  
Bufetolol hydrochloride (JP16)
D01512  
Befunolol hydrochloride (JAN)
D01520  
Levomepromazine hydrochloride (JAN/USAN)
D01521  
Pipethanate hydrochloride (JAN)
D01538  
Valethamate bromide (JAN)
D01543  
Nylidrin hydrochloride (JAN)
D01571  
Moxisylyte hydrochloride (JAN)
D01573  
Etilefrine hydrochloride (JP16)
D01589  
Mabuterol hydrochloride (JAN)
D01600  
Diphenylpiperidinomethyldioxolan iodide (JAN)
D01634  
Piretanide (JAN/USAN/INN)
D01635  
Methoxyphenamine hydrochloride (JAN)
D01648  
Hyoscyamine methylbromide (JAN)
D01674  
Naftopidil (JP16/INN)
D01691  
Nipradilol (JAN/INN)
D01692  
Alfuzosin hydrochloride (JAN/USAN)
D01699  
Darifenacin hydrobromide (JAN/USAN)
D01741  
Celiprolol hydrochloride (JAN/USAN)
D01748  
Isoxsuprine hydrochloride (JP16/USP)
D01794  
Bopindolol malonate (JAN)
D01806  
Oxprenolol hydrochloride (JP16/USP)
D01815  
Oxapium iodide (JP16/INN)
D01830  
Arotinolol hydrochloride (JP16)
D01835  
Clorprenaline hydrochloride (JAN/USAN)
D01847  
Landiolol hydrochloride (JAN)
D01871  
Metixene hydrochloride (JAN)
D01875  
Tiquizium bromide (JAN/INN)
D01887  
Bunazosin hydrochloride (JP16)
D01929  
Tiotropium bromide hydrate (JAN)
D01946  
Oxitropium bromide (JAN/INN)
D01952  
L-Methylephedrine hydrochloride (JAN)
D01955  
Aclatonium napadisilate (JAN)
D01965  
Silodosin (JAN/INN)
D01976  
N-Methylscopolamine methylsulfate (JAN)
D01978  
Trimetoquinol hydrochloride
D01987  
Pipethanate ethobromide (JAN)
D02034  
Setiptiline maleate (JAN)
D02066  
Isoprenaline sulfate (JAN)
D02069  
Atropine sulfate (JP16/USP)
D02070  
Homatropine methylbromide (USP)
D02071  
Scopolamine hydrobromide hydrate (JP16)
D02081  
Metipranolol hydrochloride
D02093  
Isoetharine hydrochloride (USP)
D02109  
dl-Methylephedrine hydrochloride (JP16)
D02147  
Albuterol (USP)
D02149  
Epinephrine bitartrate (JAN/USP)
D02150  
l-Isoprenaline hydrochloride (JP16)
D02151  
Tulobuterol (JAN/INN)
D02200  
Pilocarpine hydrochloride (JP16/USP)
D02211  
Dihydroergotamine mesilate (JP16)
D02212  
Ipratropium bromide hydrate (JP16)
D02246  
Biperiden hydrochloride (JP16/USP)
D02247  
Biperiden lactate (JAN/USP)
D02248  
Levomepromazine maleate (JP16/USAN)
D02281  
Levalbuterol hydrochloride (USAN)
D02338  
Acebutolol (USAN/INN)
D02342  
Bisoprolol (JAN/USAN/INN)
D02349  
Dipivefrin (USAN)
D02358  
Metoprolol (USAN/INN)
D02359  
Ritodrine (USAN/INN)
D02374  
Metipranolol (USAN/INN)
D02389  
Primidolol (USAN/INN)
D02396  
Hexoprenaline sulfate (USAN)
D02417  
Flutropium bromide (JAN)
D02535  
Timepidium bromide hydrate (JP16)
D02599  
Orphenadrine hydrochloride
D02614  
Denopamine (JAN/INN)
D02702  
Talibegron hydrochloride (USAN)
D02834  
Alprenoxime hydrochloride (USAN)
D02876  
Alvameline maleate (USAN)
D02976  
Arbutamine hydrochloride (USAN)
D02981  
Arformoterol tartrate (USAN)
D02995  
Asenapine maleate (USAN)
D03011  
Atropine oxide hydrochloride (USAN)
D03170  
Bucindolol hydrochloride (USAN)
D03177  
Bunolol hydrochloride (USAN)
D03195  
Butopamine (USAN/INN)
D03198  
Butoxamine hydrochloride (USAN)
D03264  
Mazaticol hydrochloride hydrate (JAN)
D03274  
Chlorpromazine hibenzate (JAN)
D03276  
Profenamine hibenzate (JAN)
D03402  
Carbuterol hydrochloride (USAN)
D03415  
Carvedilol phosphate hydrate (JAN)
D03449  
Cetamolol hydrochloride (USAN)
D03490  
Cicloprolol hydrochloride (USAN)
D03502  
Cimaterol (USAN/INN)
D03587  
Colterol mesylate (USAN)
D03648  
Dapiprazole hydrochloride (USAN)
D03654  
Darifenacin (USAN/INN)
D03711  
Dexetimide (USAN/INN)
D03729  
Dexpropranolol hydrochloride (USAN)
D03759  
Diacetolol hydrochloride (USAN)
D03814  
Atropine methylbromide (JAN)
D03879  
Dobutamine (USP/INN)
D03880  
Dobutamine lactobionate (USAN)
D03881  
Dobutamine tartrate (USP)
D03891  
Dopexamine (USAN/INN)
D04018  
Ephedrine sulfate (USP)
D04034  
Chlorpromazine phenolphthalinate (JAN)
D04057  
Esoxybutynin chloride (USAN)
D04087  
Ethybenztropine (USAN)
D04116  
Eucatropine hydrochloride (USP XXXII)
D04157  
Fenoterol (USAN/INN)
D04184  
Fiduxosin hydrochloride (USAN)
D04190  
Flestolol sulfate (USAN)
D04479  
Hyoscyamine hydrobromide (USP)
D04531  
Indoramin (USAN/INN)
D04532  
Indoramin hydrochloride (USAN)
D04625  
Isoetharine (USP)
D04626  
Isoetharine mesylate (USP)
D04701  
Levalbuterol sulfate (USAN)
D04703  
Levalbuterol tartrate (USAN)
D04708  
Levdobutamine lactobionate (USAN)
D04710  
Levobetaxolol hydrochloride (USAN)
D04888  
Medroxalol (USAN/INN)
D04889  
Medroxalol hydrochloride (USAN)
D04954  
Metaproterenol polistirex (USAN)
D04970  
Methacholine chloride (USAN/INN)
D05011  
Metoprolol fumarate (USP)
D05035  
Milameline hydrochloride (USAN)
D05037  
Trimetoquinol hydrochloride hydrate (JP16)
D05127  
Nebivolol (USAN/INN)
D05206  
Norepinephrine bitartrate (USP)
D05277  
Formoterol fumarate hydrate (JP16)
D05345  
Pamatolol sulfate (USAN)
D05366  
Procaterol hydrochloride hydrate (JP16)
D05476  
Picumeterol fumarate (USAN)
D05478  
Pilocarpine nitrate (USP)
D05587  
Practolol (USAN)
D05606  
Prenalterol hydrochloride (USAN)
D05648  
Pseudoephedrine polistirex (USAN)
D05649  
Pseudoephedrine sulfate (USP)
D05691  
Ractopamine hydrochloride (USAN)
D05718  
Reproterol hydrochloride (USAN)
D05730  
Rimiterol hydrobromide (USAN)
D05792  
Salmeterol (USAN/INN)
D05832  
Sibenadet hydrochloride (USAN)
D05879  
Solabegron hydrochloride (USAN)
D05902  
Soterenol hydrochloride (USAN)
D06273  
Imidafenacin (JAN/INN)
D06328  
Xamoterol (USAN)
D06329  
Xamoterol fumarate (USAN)
D06374  
Zinterol hydrochloride (USAN)
D06622  
Nebivolol hydrochloride (USAN)
D06623  
Olanzapine pamoate (USAN)
D06646  
Epanolol (USAN/INN)
D07099  
Cimetropium bromide (INN)
D07124  
Alfuzosin (INN)
D07148  
Oxedrine (BAN)
D07156  
Alprenolol (INN)
D07181  
Mepindolol (INN)
D07182  
Tertatolol (INN)
D07183  
Cloranolol (INN)
D07184  
Talinolol (INN)
D07349  
Choline alfoscerate (INN)
D07377  
Bambuterol (INN)
D07451  
Amosulalol (INN)
D07463  
Arformoterol (INN)
D07465  
Arotinolol (INN)
D07477  
Atropine oxide (INN)
D07489  
Bambuterol hydrochloride
D07511  
Benzatropine (INN)
D07526  
Betaxolol (INN)
D07534  
Bitolterol (INN)
D07537  
Bopindolol (INN)
D07550  
Bunazosin (INN)
D07551  
Buphenine (INN)
D07590  
Bupranolol (INN)
D07608  
Carazolol (INN)
D07624  
Carteolol (INN)
D07660  
Celiprolol (INN)
D07667  
Cevimeline (INN)
D07713  
Clenbuterol (INN)
D07759  
Cyclopentolate (INN)
D07837  
Dihydroergotamine (INN)
D07838  
Dihydroergotamine tartrate
D07874  
Doxazosin (INN)
D07905  
Ergometrine (INN)
D07906  
Ergotamine (INN)
D07916  
Esmolol (INN)
D07931  
Etilefrine (INN)
D07951  
Fentonium bromide (INN)
D07990  
Formoterol (INN)
D08039  
Hexoprenaline (INN)
D08074  
Penbutolol (INN)
D08090  
Isoprenaline (INN)
D08092  
Isoxsuprine (INN)
D08093  
Isoxsuprine lactate
D08106  
Labetalol (INN)
D08115  
Levobunolol (INN)
D08124  
Levosalbutamol (INN)
D08157  
Mazaticol (INN)
D08192  
Metaraminol (INN)
D08206  
Methylephedrine (BAN)
D08207  
Methylergometrine (INN)
D08209  
Metixene (INN)
D08220  
Midodrine (INN)
D08239  
Moxisylyte (INN)
D08253  
Naphazoline (INN)
D08284  
Norepinephrine hydrochoride
D08286  
Norfenefrine (INN)
D08300  
Orciprenaline (INN)
D08305  
Orphenadrine (INN)
D08308  
Oxedrine tartrate
D08309  
Oxedrine hydrochloride
D08318  
Oxprenolol (INN)
D08322  
Oxymetazoline (INN)
D08325  
Oxyphencyclimine (INN)
D08358  
Phenoxybenzamine (INN)
D08362  
Phentolamine (INN)
D08365  
Phenylephrine (INN)
D08366  
Phenylephrine tartrate
D08376  
Pilocarpine borate
D08382  
Piperidolate (INN)
D08384  
Pipethanate (INN)
D08387  
Pirbuterol (INN)
D08395  
Piroheptine (INN)
D08411  
Prazosin (INN)
D08424  
Procaterol (INN)
D08425  
Procyclidine (INN)
D08426  
Profenamine (INN)
D08441  
Propiverine (INN)
D08443  
Propranolol (INN)
D08449  
Pseudoephedrine (INN)
D08456  
Quetiapine (INN)
D08474  
Reproterol (INN)
D08511  
Setiptiline (INN)
D08522  
Solifenacin (INN)
D08560  
Tamsulosin (INN)
D08569  
Terazosin (INN)
D08570  
Terbutaline (INN)
D08572  
Tertatolol hydrochloride
D08578  
Tetryzoline (INN)
D08595  
Tiemonium methylsulfate
D08600  
Timolol (INN)
D08614  
Tolazoline (INN)
D08624  
Tramazoline (INN)
D08629  
Tretoquinol (INN)
D08638  
Trihexyphenidyl (INN)
D08639  
Trimebutine (INN)
D08662  
Urapidil hydrochloride
D08966  
Phenylephrine bitartrate (USP)
D09318  
Indacaterol (USAN/INN)
D09319  
Indacaterol maleate (JAN/USAN)
D09535  
Mirabegron (USAN/JAN)
D09732  
Ritobegron ethyl hydrochloride (JAN)
D09752  
Carpronium chloride hydrate (JAN)
D09794  
Norepinephrine hydrochloride (JAN)
D09842  
dl-Methylephedrine saccharinate (JAN)
D10020  
Olodaterol hydrochloride (JAN/USAN)
D10145  
Olodaterol (USAN/INN)
D10219  
Abediterol (USAN/INN)
D10220  
Abediterol napadisylate (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
153  
ADRB1; adrenoceptor beta 1 [KO:K04141]
154  
ADRB2; adrenoceptor beta 2, surface [KO:K04142]
155  
ADRB3; adrenoceptor beta 3 [KO:K04143]
2778  
GNAS; GNAS complex locus [KO:K04632]
107  
ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
108  
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
109  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
115  
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
6844  
VAMP2; vesicle-associated membrane protein 2 (synaptobrevin 2) [KO:K13504]
148  
ADRA1A; adrenoceptor alpha 1A [KO:K04135]
147  
ADRA1B; adrenoceptor alpha 1B [KO:K04136]
146  
ADRA1D; adrenoceptor alpha 1D [KO:K04137]
1131  
CHRM3; cholinergic receptor, muscarinic 3 [KO:K04131]
2776  
GNAQ; guanine nucleotide binding protein (G protein), q polypeptide [KO:K04634]
23236  
PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
5578  
PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
3708  
ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
3709  
ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
3710  
ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
6263  
RYR3; ryanodine receptor 3 [KO:K04963]
810  
CALML3; calmodulin-like 3 [KO:K02183]
805  
CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808  
CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801  
CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688  
CALML6; calmodulin-like 6 [KO:K02183]
51806  
CALML5; calmodulin-like 5 [KO:K02183]
4842  
NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
2977  
GUCY1A2; guanylate cyclase 1, soluble, alpha 2 [KO:K12318] [EC:4.6.1.2]
2982  
GUCY1A3; guanylate cyclase 1, soluble, alpha 3 [KO:K12318] [EC:4.6.1.2]
2983  
GUCY1B3; guanylate cyclase 1, soluble, beta 3 [KO:K12319] [EC:4.6.1.2]
5592  
PRKG1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
5593  
PRKG2; protein kinase, cGMP-dependent, type II [KO:K07376] [EC:2.7.11.12]
952  
CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
683  
BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:2.4.99.20 3.2.2.6]
54831  
BEST2; bestrophin 2 [KO:K13879]
362  
AQP5; aquaporin 5 [KO:K09867]
476  
ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide [KO:K01539] [EC:3.6.3.9]
477  
ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide [KO:K01539] [EC:3.6.3.9]
478  
ATP1A3; ATPase, Na+/K+ transporting, alpha 3 polypeptide [KO:K01539] [EC:3.6.3.9]
480  
ATP1A4; ATPase, Na+/K+ transporting, alpha 4 polypeptide [KO:K01539] [EC:3.6.3.9]
23439  
ATP1B4; ATPase, Na+/K+ transporting, beta 4 polypeptide [KO:K01540]
481  
ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide [KO:K01540]
482  
ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide [KO:K01540]
483  
ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide [KO:K01540]
486  
FXYD2; FXYD domain containing ion transport regulator 2 [KO:K01538]
490  
ATP2B1; ATPase, Ca++ transporting, plasma membrane 1 [KO:K05850] [EC:3.6.3.8]
492  
ATP2B3; ATPase, Ca++ transporting, plasma membrane 3 [KO:K05850] [EC:3.6.3.8]
493  
ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 [KO:K05850] [EC:3.6.3.8]
491  
ATP2B2; ATPase, Ca++ transporting, plasma membrane 2 [KO:K05850] [EC:3.6.3.8]
6558  
SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporter), member 2 [KO:K10951]
3783  
KCNN4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [KO:K04945]
3778  
KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [KO:K04936]
6522  
SLC4A2; solute carrier family 4 (anion exchanger), member 2 [KO:K13855]
6548  
SLC9A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 [KO:K05742]
55503  
TRPV6; transient receptor potential cation channel, subfamily V, member 6 [KO:K04975]
727897  
MUC5B; mucin 5B, oligomeric mucus/gel-forming [KO:K13908]
4589  
MUC7; mucin 7, secreted [KO:K13909]
5555  
PRH2; proline-rich protein HaeIII subfamily 2 [KO:K13910]
5554  
PRH1; proline-rich protein HaeIII subfamily 1 [KO:K13910]
5542  
PRB1; proline-rich protein BstNI subfamily 1 [KO:K13911]
653247  
PRB2; proline-rich protein BstNI subfamily 2 [KO:K13911]
1755  
DMBT1; deleted in malignant brain tumors 1 [KO:K13912]
1469  
CST1; cystatin SN [KO:K13897]
1470  
CST2; cystatin SA [KO:K13898]
1471  
CST3; cystatin C [KO:K13899]
1472  
CST4; cystatin S [KO:K13900]
1473  
CST5; cystatin D [KO:K13901]
3346  
HTN1; histatin 1 [KO:K13913]
3347  
HTN3; histatin 3 [KO:K13913]
6779  
STATH; statherin [KO:K13914]
4069  
LYZ; lysozyme [KO:K13915] [EC:3.2.1.17]
4025  
LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
820  
CAMP; cathelicidin antimicrobial peptide [KO:K13916]
276  
AMY1A; amylase, alpha 1A (salivary) [KO:K01176] [EC:3.2.1.1]
277  
AMY1B; amylase, alpha 1B (salivary) [KO:K01176] [EC:3.2.1.1]
278  
AMY1C; amylase, alpha 1C (salivary) [KO:K01176] [EC:3.2.1.1]
Compound
C00001  
H2O
C00011  
CO2
C00076  
Calcium cation
C00080  
H+
C00165  
Diacylglycerol
C00238  
Potassium cation
C00288  
HCO3-
C00533  
Nitric oxide
C00547  
L-Noradrenaline
C00575  
3',5'-Cyclic AMP
C00698  
Cl-
C00942  
3',5'-Cyclic GMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01330  
Sodium cation
C01353  
Carbonic acid
C01996  
Acetylcholine
C13050  
Cyclic ADP-ribose
Reference
  Authors
Ishikawa Y, Cho G, Yuan Z, Skowronski MT, Pan Y, Ishida H
  Title
Water channels and zymogen granules in salivary glands.
  Journal
J Pharmacol Sci 100:495-512 (2006)
Reference
  Authors
Ishikawa Y, Cho G, Yuan Z, Inoue N, Nakae Y
  Title
Aquaporin-5 water channel in lipid rafts of rat parotid glands.
  Journal
Biochim Biophys Acta 1758:1053-60 (2006)
Reference
  Authors
Ambudkar IS
  Title
Regulation of calcium in salivary gland secretion.
  Journal
Crit Rev Oral Biol Med 11:4-25 (2000)
Reference
  Authors
Ishikawa Y, Ishida H
  Title
Aquaporin water channel in salivary glands.
  Journal
Jpn J Pharmacol 83:95-101 (2000)
Reference
PMID:8105741
  Authors
Baum BJ
  Title
Principles of saliva secretion.
  Journal
Ann N Y Acad Sci 694:17-23 (1993)
Reference
PMID:9720759
  Authors
Fujita-Yoshigaki J
  Title
Divergence and convergence in regulated exocytosis: the characteristics of cAMP-dependent enzyme secretion of parotid salivary acinar cells.
  Journal
Cell Signal 10:371-5 (1998)
Reference
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
Reference
  Authors
Proctor GB, Carpenter GH
  Title
Regulation of salivary gland function by autonomic nerves.
  Journal
Auton Neurosci 133:3-18 (2007)
Reference
  Authors
Turner RJ, Sugiya H
  Title
Understanding salivary fluid and protein secretion.
  Journal
Oral Dis 8:3-11 (2002)
Reference
  Authors
Van Nieuw Amerongen A, Bolscher JG, Veerman EC
  Title
Salivary proteins: protective and diagnostic value in cariology?
  Journal
Caries Res 38:247-53 (2004)
Reference
  Authors
Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE
  Title
Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells.
  Journal
Am J Physiol Regul Integr Comp Physiol 292:R2380-90 (2007)
Reference
  Authors
Melvin JE, Yule D, Shuttleworth T, Begenisich T
  Title
Regulation of fluid and electrolyte secretion in salivary gland acinar cells.
  Journal
Annu Rev Physiol 67:445-69 (2005)
Reference
  Authors
Catalan MA, Nakamoto T, Melvin JE
  Title
The salivary gland fluid secretion mechanism.
  Journal
J Med Invest 56 Suppl:192-6 (2009)
KO pathway
 

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