KEGG   PATHWAY: hsa05160Help
Entry
hsa05160                    Pathway                                

Name
Hepatitis C - Homo sapiens (human)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Hepatitis C
hsa05160

All organismsOrtholog table
Disease
H00413  
Hepatitis C
Drug
D00745  
Interferon alfa-2a (genetical recombination) (JAN)
D03304  
Interferon beta (JAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
3949  
LDLR; low density lipoprotein receptor [KO:K12473]
949  
SCARB1; scavenger receptor class B, member 1 [KO:K13885]
975  
CD81; CD81 molecule [KO:K06508]
1364  
CLDN4; claudin 4 [KO:K06087]
1365  
CLDN3; claudin 3 [KO:K06087]
1366  
CLDN7; claudin 7 [KO:K06087]
149461  
CLDN19; claudin 19 [KO:K06087]
10686  
CLDN16; claudin 16 [KO:K06087]
23562  
CLDN14; claudin 14 [KO:K06087]
24146  
CLDN15; claudin 15 [KO:K06087]
26285  
CLDN17; claudin 17 [KO:K06087]
49861  
CLDN20; claudin 20 [KO:K06087]
5010  
CLDN11; claudin 11 [KO:K06087]
51208  
CLDN18; claudin 18 [KO:K06087]
53842  
CLDN22; claudin 22 [KO:K06087]
7122  
CLDN5; claudin 5 [KO:K06087]
9071  
CLDN10; claudin 10 [KO:K06087]
9073  
CLDN8; claudin 8 [KO:K06087]
9074  
CLDN6; claudin 6 [KO:K06087]
9075  
CLDN2; claudin 2 [KO:K06087]
9076  
CLDN1; claudin 1 [KO:K06087]
9080  
CLDN9; claudin 9 [KO:K06087]
137075  
CLDN23; claudin 23 [KO:K06087]
644672  
CLDN25; claudin 25 [KO:K06087]
CLDN24; claudin 24 [KO:K06087]
OCLN; occludin [KO:K06088]
4938  
OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa [KO:K14216]
4939  
OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa [KO:K14216]
4940  
OAS3; 2'-5'-oligoadenylate synthetase 3, 100kDa [KO:K14216]
6041  
RNASEL; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) [KO:K01165]
23586  
DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
57506  
MAVS; mitochondrial antiviral signaling protein [KO:K12648]
7187  
TRAF3; TNF receptor-associated factor 3 [KO:K03174]
29110  
TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
9641  
IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
3661  
IRF3; interferon regulatory factor 3 [KO:K05411]
3665  
IRF7; interferon regulatory factor 7 [KO:K09447]
3456  
IFNB1; interferon, beta 1, fibroblast [KO:K05415]
7098  
TLR3; toll-like receptor 3 [KO:K05401]
148022  
TICAM1; toll-like receptor adaptor molecule 1 [KO:K05842]
7189  
TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
8737  
RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
8517  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
4792  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4790  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970  
RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
27102  
EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610  
EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451  
EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275  
EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
3659  
IRF1; interferon regulatory factor 1 [KO:K09444]
1965  
EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [KO:K03237]
3576  
CXCL8; chemokine (C-X-C motif) ligand 8 [KO:K10030]
6774  
STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO:K04692]
3434  
IFIT1; interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
439996  
IFIT1B; interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
3646  
EIF3E; eukaryotic translation initiation factor 3, subunit E [KO:K03250]
3439  
IFNA1; interferon, alpha 1 [KO:K05414]
3440  
IFNA2; interferon, alpha 2 [KO:K05414]
3441  
IFNA4; interferon, alpha 4 [KO:K05414]
3442  
IFNA5; interferon, alpha 5 [KO:K05414]
3443  
IFNA6; interferon, alpha 6 [KO:K05414]
3444  
IFNA7; interferon, alpha 7 [KO:K05414]
3445  
IFNA8; interferon, alpha 8 [KO:K05414]
3446  
IFNA10; interferon, alpha 10 [KO:K05414]
3447  
IFNA13; interferon, alpha 13 [KO:K05414]
3448  
IFNA14; interferon, alpha 14 [KO:K05414]
3449  
IFNA16; interferon, alpha 16 [KO:K05414]
3451  
IFNA17; interferon, alpha 17 [KO:K05414]
3452  
IFNA21; interferon, alpha 21 [KO:K05414]
3454  
IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
3455  
IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
3716  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
7297  
TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6772  
STAT1; signal transducer and activator of transcription 1, 91kDa [KO:K11220]
6773  
STAT2; signal transducer and activator of transcription 2, 113kDa [KO:K11221]
10379  
IRF9; interferon regulatory factor 9 [KO:K04693]
9021  
SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
5519  
PPP2R1B; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
5518  
PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
5520  
PPP2R2A; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354]
5521  
PPP2R2B; protein phosphatase 2, regulatory subunit B, beta [KO:K04354]
5522  
PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
55844  
PPP2R2D; protein phosphatase 2, regulatory subunit B, delta [KO:K04354]
5515  
PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme [KO:K04382] [EC:3.1.3.16]
5516  
PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme [KO:K04382] [EC:3.1.3.16]
8554  
PIAS1; protein inhibitor of activated STAT, 1 [KO:K04706] [EC:6.3.2.-]
1950  
EGF; epidermal growth factor [KO:K04357]
1956  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2885  
GRB2; growth factor receptor-bound protein 2 [KO:K04364]
6654  
SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
6655  
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
369  
ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
5600  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
5599  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5295  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5170  
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
207  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
572  
BAD; BCL2-associated agonist of cell death [KO:K02158]
7157  
TP53; tumor protein p53 [KO:K04451]
1026  
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
7124  
TNF; tumor necrosis factor [KO:K03156]
7132  
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
7186  
TRAF2; TNF receptor-associated factor 2 [KO:K03173]
8717  
TRADD; TNFRSF1A-associated via death domain [KO:K03171]
10197  
PSME3; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma [KO:K06698]
6256  
RXRA; retinoid X receptor, alpha [KO:K08524]
5465  
PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
10062  
NR1H3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18288  
Core protein
C18289  
Envelope glycoprotein E2
C18290  
Serine protease NS3
C18291  
Non-structural protein 4A
C18292  
Non-structural protein 5A
Reference
  Authors
Polyak SJ
  Title
Hepatitis C virus--cell interactions and their role in pathogenesis.
  Journal
Clin Liver Dis 7:67-88 (2003)
Reference
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
Reference
  Authors
Giannini C, Brechot C
  Title
Hepatitis C virus biology.
  Journal
Cell Death Differ 10 Suppl 1:S27-38 (2003)
Reference
  Authors
Tang H, Grise H
  Title
Cellular and molecular biology of HCV infection and hepatitis.
  Journal
Clin Sci (Lond) 117:49-65 (2009)
Reference
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
Reference
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
Reference
  Authors
Georgel P, Schuster C, Zeisel MB, Stoll-Keller F, Berg T, Bahram S, Baumert TF
  Title
Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies.
  Journal
Trends Mol Med 16:277-86 (2010)
Reference
  Authors
Freundt EC, Lenardo MJ
  Title
Interfering with interferons: Hepatitis C virus counters innate immunity.
  Journal
Proc Natl Acad Sci U S A 102:17539-40 (2005)
Reference
  Authors
Ishii S, Koziel MJ
  Title
Immune responses during acute and chronic infection with hepatitis C virus.
  Journal
Clin Immunol 128:133-47 (2008)
Reference
  Authors
Asselah T, Bieche I, Sabbagh A, Bedossa P, Moreau R, Valla D, Vidaud M, Marcellin P
  Title
Gene expression and hepatitis C virus infection.
  Journal
Gut 58:846-58 (2009)
Reference
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
Reference
  Authors
Han JQ, Barton DJ
  Title
Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.
  Journal
RNA 8:512-25 (2002)
Reference
  Authors
Negro F, Sanyal AJ
  Title
Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data.
  Journal
Liver Int 29 Suppl 2:26-37 (2009)
Reference
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
Reference
  Authors
Tan SL (ed).
  Title
Hepatitis C Viruses Genomes and Molecular Biology
  Journal
Horizon Bioscience (2006)
KO pathway
 

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