KEGG PATHWAY: hsa05160

PATHWAY: hsa05160

Entry

hsa05160 Pathway

Name

Hepatitis C - Homo sapiens (human)

Description

Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.

Class

Human Diseases; Infectious diseases

Pathway map

hsa05160

Hepatitis C

Disease

H00413

Hepatitis C

Drug

D00745	Interferon alfa-2a (genetical recombination) (JAN)
D03304	Interferon beta (JAN)

Organism

Homo sapiens (human) [GN:hsa]

Gene

3949	LDLR; low density lipoprotein receptor [KO:K12473]
949	SCARB1; scavenger receptor class B, member 1 [KO:K13885]
975	CD81; CD81 molecule [KO:K06508]
1364	CLDN4; claudin 4 [KO:K06087]
1365	CLDN3; claudin 3 [KO:K06087]
1366	CLDN7; claudin 7 [KO:K06087]
149461	CLDN19; claudin 19 [KO:K06087]
10686	CLDN16; claudin 16 [KO:K06087]
23562	CLDN14; claudin 14 [KO:K06087]
24146	CLDN15; claudin 15 [KO:K06087]
26285	CLDN17; claudin 17 [KO:K06087]
49861	CLDN20; claudin 20 [KO:K06087]
5010	CLDN11; claudin 11 [KO:K06087]
51208	CLDN18; claudin 18 [KO:K06087]
53842	CLDN22; claudin 22 [KO:K06087]
7122	CLDN5; claudin 5 [KO:K06087]
9071	CLDN10; claudin 10 [KO:K06087]
9073	CLDN8; claudin 8 [KO:K06087]
9074	CLDN6; claudin 6 [KO:K06087]
9075	CLDN2; claudin 2 [KO:K06087]
9076	CLDN1; claudin 1 [KO:K06087]
9080	CLDN9; claudin 9 [KO:K06087]
137075	CLDN23; claudin 23 [KO:K06087]
644672	CLDN25; claudin 25 [KO:K06087]
100132463	CLDN24; claudin 24 [KO:K06087]
100506658	OCLN; occludin [KO:K06088]
4938	OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa [KO:K14216]
4939	OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa [KO:K14216]
4940	OAS3; 2'-5'-oligoadenylate synthetase 3, 100kDa [KO:K14216]
6041	RNASEL; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) [KO:K01165]
23586	DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
57506	MAVS; mitochondrial antiviral signaling protein [KO:K12648]
7187	TRAF3; TNF receptor-associated factor 3 [KO:K03174]
29110	TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
9641	IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
3661	IRF3; interferon regulatory factor 3 [KO:K05411]
3665	IRF7; interferon regulatory factor 7 [KO:K09447]
3456	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
7098	TLR3; toll-like receptor 3 [KO:K05401]
148022	TICAM1; toll-like receptor adaptor molecule 1 [KO:K05842]
7189	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
8737	RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
1147	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
8517	IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
4792	NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4790	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
27102	EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610	EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451	EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275	EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
3659	IRF1; interferon regulatory factor 1 [KO:K09444]
1965	EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [KO:K03237]
3576	IL8; interleukin 8 [KO:K10030]
6774	STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO:K04692]
3434	IFIT1; interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
439996	IFIT1B; interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
3646	EIF3E; eukaryotic translation initiation factor 3, subunit E [KO:K03250]
3439	IFNA1; interferon, alpha 1 [KO:K05414]
3440	IFNA2; interferon, alpha 2 [KO:K05414]
3441	IFNA4; interferon, alpha 4 [KO:K05414]
3442	IFNA5; interferon, alpha 5 [KO:K05414]
3443	IFNA6; interferon, alpha 6 [KO:K05414]
3444	IFNA7; interferon, alpha 7 [KO:K05414]
3445	IFNA8; interferon, alpha 8 [KO:K05414]
3446	IFNA10; interferon, alpha 10 [KO:K05414]
3447	IFNA13; interferon, alpha 13 [KO:K05414]
3448	IFNA14; interferon, alpha 14 [KO:K05414]
3449	IFNA16; interferon, alpha 16 [KO:K05414]
3451	IFNA17; interferon, alpha 17 [KO:K05414]
3452	IFNA21; interferon, alpha 21 [KO:K05414]
3454	IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
3455	IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
3716	JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
7297	TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6772	STAT1; signal transducer and activator of transcription 1, 91kDa [KO:K11220]
6773	STAT2; signal transducer and activator of transcription 2, 113kDa [KO:K11221]
10379	IRF9; interferon regulatory factor 9 [KO:K04693]
9021	SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
5519	PPP2R1B; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
5518	PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
5520	PPP2R2A; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354]
5521	PPP2R2B; protein phosphatase 2, regulatory subunit B, beta [KO:K04354]
5522	PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
55844	PPP2R2D; protein phosphatase 2, regulatory subunit B, delta [KO:K04354]
5515	PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme [KO:K04382] [EC:3.1.3.16]
5516	PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme [KO:K04382] [EC:3.1.3.16]
8554	PIAS1; protein inhibitor of activated STAT, 1 [KO:K04706] [EC:6.3.2.-]
1950	EGF; epidermal growth factor [KO:K04357]
1956	EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2885	GRB2; growth factor receptor-bound protein 2 [KO:K04364]
6654	SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
6655	SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
3265	HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
673	BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
5894	RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
369	ARAF; v-raf murine sarcoma 3611 viral oncogene homolog [KO:K08845] [EC:2.7.11.1]
5600	MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603	MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
5599	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5594	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5295	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5163	PDK1; pyruvate dehydrogenase kinase, isozyme 1 [KO:K12077] [EC:2.7.11.2]
207	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
2932	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
572	BAD; BCL2-associated agonist of cell death [KO:K02158]
7157	TP53; tumor protein p53 [KO:K04451]
1026	CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
7124	TNF; tumor necrosis factor [KO:K03156]
7132	TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
7186	TRAF2; TNF receptor-associated factor 2 [KO:K03173]
8717	TRADD; TNFRSF1A-associated via death domain [KO:K03171]
10197	PSME3; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma [KO:K06698]
6256	RXRA; retinoid X receptor, alpha [KO:K08524]
5465	PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
10062	NR1H3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]

Compound

C00027	Hydrogen peroxide
C00076	Calcium cation
C05981	Phosphatidylinositol-3,4,5-trisphosphate
C18288	Core protein
C18289	Envelope glycoprotein E2
C18290	Serine protease NS3
C18291	Non-structural protein 4A
C18292	Non-structural protein 5A

Reference

PMID:12691459

Authors

Polyak SJ

Title

Hepatitis C virus--cell interactions and their role in pathogenesis.

Journal

Clin Liver Dis 7:67-88 (2003)

Reference

PMID:16107833

Authors

Gale M Jr, Foy EM

Title

Evasion of intracellular host defence by hepatitis C virus.

Journal

Nature 436:939-45 (2005)

Reference

PMID:12655344

Authors

Giannini C, Brechot C

Title

Hepatitis C virus biology.

Journal

Cell Death Differ 10 Suppl 1:S27-38 (2003)

Reference

PMID:19515018

Authors

Tang H, Grise H

Title

Cellular and molecular biology of HCV infection and hepatitis.

Journal

Clin Sci (Lond) 117:49-65 (2009)

Reference

PMID:19708811

Authors

Horner SM, Gale M Jr

Title

Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.

Journal

J Interferon Cytokine Res 29:489-98 (2009)

Reference

PMID:17467654

Authors

Bode JG, Brenndorfer ED, Haussinger D

Title

Subversion of innate host antiviral strategies by the hepatitis C virus.

Journal

Arch Biochem Biophys 462:254-65 (2007)

Reference

PMID:20537953

Authors

Georgel P, Schuster C, Zeisel MB, Stoll-Keller F, Berg T, Bahram S, Baumert TF

Title

Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies.

Journal

Trends Mol Med 16:277-86 (2010)

Reference

PMID:16314558

Authors

Freundt EC, Lenardo MJ

Title

Interfering with interferons: Hepatitis C virus counters innate immunity.

Journal

Proc Natl Acad Sci U S A 102:17539-40 (2005)

Reference

PMID:18514579

Authors

Ishii S, Koziel MJ

Title

Immune responses during acute and chronic infection with hepatitis C virus.

Journal

Clin Immunol 128:133-47 (2008)

Reference

PMID:19074178

Authors

Asselah T, Bieche I, Sabbagh A, Bedossa P, Moreau R, Valla D, Vidaud M, Marcellin P

Title

Gene expression and hepatitis C virus infection.

Journal

Gut 58:846-58 (2009)

Reference

PMID:15302943

Authors

Macdonald A, Harris M

Title

Hepatitis C virus NS5A: tales of a promiscuous protein.

Journal

J Gen Virol 85:2485-502 (2004)

Reference

PMID:11991644

Authors

Han JQ, Barton DJ

Title

Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.

Journal

RNA 8:512-25 (2002)

Reference

PMID:19187070

Authors

Negro F, Sanyal AJ

Title

Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data.

Journal

Liver Int 29 Suppl 2:26-37 (2009)

Reference

PMID:19148799

Authors

Koike K

Title

Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.

Journal

J Gastroenterol 44 Suppl 19:82-8 (2009)

Reference

Authors

Tan SL (ed).

Title

Hepatitis C Viruses Genomes and Molecular Biology

Journal

Horizon Bioscience (2006)

KO pathway

ko05160

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   BioSystems (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (133)   
   KEGG GENES (133)   
All databases (141)   

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