KEGG   PATHWAY: hsa05162Help
Entry
hsa05162                    Pathway                                

Name
Measles - Homo sapiens (human)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Measles
hsa05162

All organismsOrtholog table
Disease
H00394  
Measles
Organism
Homo sapiens (human) [GN:hsa]
Gene
4478  
MSN; moesin [KO:K05763]
10332  
CLEC4M; C-type lectin domain family 4 member M [KO:K06563]
30835  
CD209; CD209 molecule [KO:K06563]
6869  
TACR1; tachykinin receptor 1 [KO:K04222]
4179  
CD46; CD46 molecule [KO:K04007]
6504  
SLAMF1; signaling lymphocytic activation molecule family member 1 [KO:K06536]
4068  
SH2D1A; SH2 domain containing 1A [KO:K07990]
2534  
FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
1796  
DOK1; docking protein 1 [KO:K14752]
5588  
PRKCQ; protein kinase C theta [KO:K18052] [EC:2.7.11.13]
3596  
IL13; interleukin 13 [KO:K05435]
3565  
IL4; interleukin 4 [KO:K05430]
915  
CD3D; CD3d molecule [KO:K06450]
916  
CD3E; CD3e molecule [KO:K06451]
917  
CD3G; CD3g molecule [KO:K06452]
940  
CD28; CD28 molecule [KO:K06470]
3558  
IL2; interleukin 2 [KO:K05429]
3559  
IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3560  
IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  
IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
207  
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
3716  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
3718  
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
6774  
STAT3; signal transducer and activator of transcription 3 [KO:K04692]
6776  
STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
6777  
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
23586  
DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:3.6.3.14]
64135  
IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
57506  
MAVS; mitochondrial antiviral signaling protein [KO:K12648]
9641  
IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
29110  
TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
3661  
IRF3; interferon regulatory factor 3 [KO:K05411]
51284  
TLR7; toll like receptor 7 [KO:K05404]
54106  
TLR9; toll like receptor 9 [KO:K10161]
4615  
MYD88; myeloid differentiation primary response 88 [KO:K04729]
3654  
IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
51135  
IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
3665  
IRF7; interferon regulatory factor 7 [KO:K09447]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
7097  
TLR2; toll like receptor 2 [KO:K10159]
7099  
TLR4; toll like receptor 4 [KO:K10160]
7189  
TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
6885  
MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
23118  
TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
4793  
NFKBIB; NFKB inhibitor beta [KO:K02581]
4792  
NFKBIA; NFKB inhibitor alpha [KO:K04734]
4790  
NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  
RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
1457  
CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
1459  
CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
283106  
CSNK2A3; casein kinase 2 alpha 3 [KO:K03097] [EC:2.7.11.1]
1460  
CSNK2B; casein kinase 2 beta [KO:K03115]
7128  
TNFAIP3; TNF alpha induced protein 3 [KO:K11859] [EC:3.4.19.12]
3439  
IFNA1; interferon alpha 1 [KO:K05414]
3440  
IFNA2; interferon alpha 2 [KO:K05414]
3441  
IFNA4; interferon alpha 4 [KO:K05414]
3442  
IFNA5; interferon alpha 5 [KO:K05414]
3443  
IFNA6; interferon alpha 6 [KO:K05414]
3444  
IFNA7; interferon alpha 7 [KO:K05414]
3445  
IFNA8; interferon alpha 8 [KO:K05414]
3446  
IFNA10; interferon alpha 10 [KO:K05414]
3447  
IFNA13; interferon alpha 13 [KO:K05414]
3448  
IFNA14; interferon alpha 14 [KO:K05414]
3449  
IFNA16; interferon alpha 16 [KO:K05414]
3451  
IFNA17; interferon alpha 17 [KO:K05414]
3452  
IFNA21; interferon alpha 21 [KO:K05414]
3456  
IFNB1; interferon beta 1 [KO:K05415]
3552  
IL1A; interleukin 1 alpha [KO:K04383]
3553  
IL1B; interleukin 1 beta [KO:K04519]
3569  
IL6; interleukin 6 [KO:K05405]
3592  
IL12A; interleukin 12A [KO:K05406]
3593  
IL12B; interleukin 12B [KO:K05425]
IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
2213  
FCGR2B; Fc fragment of IgG receptor IIb [KO:K12560]
3454  
IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
3455  
IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
10399  
RACK1; receptor for activated C kinase 1 [KO:K14753]
7297  
TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6772  
STAT1; signal transducer and activator of transcription 1 [KO:K11220]
6773  
STAT2; signal transducer and activator of transcription 2 [KO:K11221]
10379  
IRF9; interferon regulatory factor 9 [KO:K04693]
3458  
IFNG; interferon gamma [KO:K04687]
3459  
IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460  
IFNGR2; interferon gamma receptor 2 [KO:K05133]
3717  
JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
4938  
OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
4939  
OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
4940  
OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
103  
ADAR; adenosine deaminase, RNA specific [KO:K12968] [EC:3.5.4.37]
4599  
MX1; MX dynamin like GTPase 1 [KO:K14754]
595  
CCND1; cyclin D1 [KO:K04503]
894  
CCND2; cyclin D2 [KO:K10151]
896  
CCND3; cyclin D3 [KO:K10152]
898  
CCNE1; cyclin E1 [KO:K06626]
9134  
CCNE2; cyclin E2 [KO:K06626]
1019  
CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
1021  
CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
1017  
CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
1027  
CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
9367  
RAB9A; RAB9A, member RAS oncogene family [KO:K07899]
51209  
RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
3312  
HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
3303  
HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
3306  
HSPA2; heat shock protein family A (Hsp70) member 2 [KO:K03283]
3305  
HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
3304  
HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
3310  
HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
8667  
EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
27102  
EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610  
EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451  
EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275  
EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
1965  
EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
25898  
RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
7157  
TP53; tumor protein p53 [KO:K04451]
7161  
TP73; tumor protein p73 [KO:K10148]
27113  
BBC3; BCL2 binding component 3 [KO:K10132]
356  
FASLG; Fas ligand [KO:K04389]
355  
FAS; Fas cell surface death receptor [KO:K04390]
8743  
TNFSF10; TNF superfamily member 10 [KO:K04721]
8797  
TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722]
8795  
TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722]
8794  
TNFRSF10C; TNF receptor superfamily member 10c [KO:K04722]
8793  
TNFRSF10D; TNF receptor superfamily member 10d [KO:K04722]
868  
CBLB; Cbl proto-oncogene B [KO:K04707] [EC:2.3.2.27]
Compound
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
  Authors
Navaratnarajah CK, Leonard VH, Cattaneo R
  Title
Measles virus glycoprotein complex assembly, receptor attachment, and cell entry.
  Journal
Curr Top Microbiol Immunol 329:59-76 (2009)
DOI:10.1007/978-3-540-70523-9_4
Reference
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
  Authors
Naniche D
  Title
Human immunology of measles virus infection.
  Journal
Curr Top Microbiol Immunol 330:151-71 (2009)
DOI:10.1007/978-3-540-70617-5_8
Reference
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Reference
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression: from effectors to mechanisms.
  Journal
Med Microbiol Immunol 199:227-37 (2010)
DOI:10.1007/s00430-010-0152-3
Reference
  Authors
Schneider-Schaulies J, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus interactions with cellular receptors: consequences for viral pathogenesis.
  Journal
J Neurovirol 7:391-9 (2001)
DOI:10.1080/135502801753170246
Reference
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
  Authors
Gotoh B, Komatsu T, Takeuchi K, Yokoo J
  Title
Paramyxovirus strategies for evading the interferon response.
  Journal
Rev Med Virol 12:337-57 (2002)
DOI:10.1002/rmv.357
Reference
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
KO pathway
 

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